Protein Alignment Nedd4 and HUL4

DIOPT Version :10

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: NP_012570.3
• Gene: HUL4 / 853494
• SGDID: S000003797
• Length: 892
• Species: Saccharomyces cerevisiae
• Alignment Length: 774
• Identity: 184/774 - (23%)
• Similarity: 306/774 - (39%)
• Gaps: 165/774 - (21%)

  Fly   352 GILAQIAMQYRAEEDQDPTVDHTSFV------------------YNSLRHPVAHRQPEISATSLQ 398
            |::.|..:.|..:...|.::.:.||:                  :.|:...:..|:|..|.....
Yeast   159 GLIFQPVITYLLDRFHDVSILNRSFLVHDGGKNIKMLNYEVLQRFYSILSNLPTRKPYYSMLCCC 223

  Fly   399 NDL-----------------RPVREAPGVPDI--------------------AITNPFTRRAAG- 425
            |||                 |.:.....:|.|                    |::....:|..|
Yeast   224 NDLLKRITINKGENLQILQYRWLLIILNIPTIRTCLIRDRKSKNVFETQQIRAVSYELAKRCIGY 288

  Fly   426 --NMAGGAGWQ--QERRR----------QQMQLHIQ-QHQQRQQQQQQNRILLDVDHRQQEPQHR 475
              |::.....|  |..||          :.:.|:|. |..:....:..||...:....:.|.:.|
Yeast   289 LSNLSTKTSQQLIQSLRRTPTDNFSYQVEILNLYINFQFSRLLSNELSNRTAKNNVKPEDEMRSR 353

  Fly   476 GQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVA 540
            .:||            ||..|     ...|||..|.:.|      ::...|...|:..:...:..
Yeast   354 LRRH------------HTTGH-----EFLSTRPISAQSN------DKQGSGFTHPVNNKMKFKFF 395

  Fly   541 PNGRTFFIDHASRRTTWI-----DPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYID 600
            .....:.| |::.:.|:|     ..||||.:........:..|.....:.::   |..|......
Yeast   396 QYEEDWHI-HSAAKLTFIYYVANTRRNGRGALSIQSFYNITLDFIDYKQDFD---HWRGVAQKTK 456

  Fly   601 HNTRTTQWEDPRLSN-------PNIAGQAVPYS-RDYK-------QKYEYFKSHIRKPTNVPNKF 650
            .|....:|.:.....       |.|....:..| .:|:       :..:.|...:.|..:|...|
Yeast   457 MNQLIEEWGNSTTKKCFSFCKYPFILSLGIKISIMEYEIRRIMEHEAEQAFLISLDKGKSVDVYF 521

  Fly   651 EIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLF 715
            :|::||..|..||.|.|.. .:.||||: |.:||..|.|:|.|||.:|||:||:|.:|||..|||
Yeast   522 KIKVRRDVISHDSLRCIKE-HQGDLLKS-LRIEFVNEPGIDAGGLRKEWFFLLTKSLFNPMNGLF 584

  Fly   716 EY--------SAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMML 772
            .|        .|:|......:.|.   |.:...|:.| |.:.|:|:::..:||..|.:..||.:.
Yeast   585 IYIKESSRSWFAIDPPNFDKSKGK---NSQLELYYLF-GVVMGLAIFNSTILDLQFPKALYKKLC 645

  Fly   773 QKPIDLKDMESVDTEYYNSLM----WIKENDPRILELTFCLDEDVF--------GQKSQH----- 820
            .:|:..:|...:..|...:|:    :.::|...:..|||   |..:        ..||..
Yeast   646 SEPLSFEDYSELFPETSRNLIKMLNYTEDNFEDVFSLTF---ETTYRNNNWILNDSKSSKEYVTV 707

  Fly   821 ELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSII-PLNLIKIFDEHELELLM 884
            ||...|.|:.:|..||.|::...:|:.....::.|.:.|:.||..:. ..|.||:|:..|||.|:
Yeast   708 ELCENGRNVPITQSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLV 772

  Fly   885 CGIQ---NIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFK 946
            ||.:   ..|.|..|..|.|.|.:..:...:.|||..:.|:...::.:||||||.:.|:|..|..
Yeast   773 CGDEEQTKFDFKSLRSVTKYVGGFSDDSRAVCWFWEIIESWDYPLQKKLLQFVTASDRIPATGIS 837

  Fly   947 ELYGSNGPQMFTIEKWGT--PNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            .:       .|.|...|:  .::.|.||||||.:.|..|....:|:.||:.||..|:|:
Yeast   838 TI-------PFKISLLGSHDSDDLPLAHTCFNEICLWNYSSKKKLELKLLWAINESEGY 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:459800
		HUL4	<523..1003	CDD:227354	142/530 (27%)
HUL4	NP_012570.3	HUL4	1..892	CDD:227354	184/774 (24%)