DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and HUL4

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_012570.3	Gene:	HUL4 / 853494	SGDID:	S000003797	Length:	892	Species:	Saccharomyces cerevisiae

Alignment Length:	774	Identity:	184/774 - (23%)
Similarity:	306/774 - (39%)	Gaps:	165/774 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 GILAQIAMQYRAEEDQDPTVDHTSFV------------------YNSLRHPVAHRQPEISATSLQ 398
            |::.|..:.|..:...|.::.:.||:                  :.|:...:..|:|..|.....
Yeast   159 GLIFQPVITYLLDRFHDVSILNRSFLVHDGGKNIKMLNYEVLQRFYSILSNLPTRKPYYSMLCCC 223

  Fly   399 NDL-----------------RPVREAPGVPDI--------------------AITNPFTRRAAG- 425
            |||                 |.:.....:|.|                    |::....:|..|
Yeast   224 NDLLKRITINKGENLQILQYRWLLIILNIPTIRTCLIRDRKSKNVFETQQIRAVSYELAKRCIGY 288

  Fly   426 --NMAGGAGWQ--QERRR----------QQMQLHIQ-QHQQRQQQQQQNRILLDVDHRQQEPQHR 475
              |::.....|  |..||          :.:.|:|. |..:....:..||...:....:.|.:.|
Yeast   289 LSNLSTKTSQQLIQSLRRTPTDNFSYQVEILNLYINFQFSRLLSNELSNRTAKNNVKPEDEMRSR 353

  Fly   476 GQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVA 540
            .:||            ||..|     ...|||..|.:.|      ::...|...|:..:...:..
Yeast   354 LRRH------------HTTGH-----EFLSTRPISAQSN------DKQGSGFTHPVNNKMKFKFF 395

  Fly   541 PNGRTFFIDHASRRTTWI-----DPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYID 600
            .....:.| |::.:.|:|     ..||||.:........:..|.....:.::   |..|......
Yeast   396 QYEEDWHI-HSAAKLTFIYYVANTRRNGRGALSIQSFYNITLDFIDYKQDFD---HWRGVAQKTK 456

  Fly   601 HNTRTTQWEDPRLSN-------PNIAGQAVPYS-RDYK-------QKYEYFKSHIRKPTNVPNKF 650
            .|....:|.:.....       |.|....:..| .:|:       :..:.|...:.|..:|...|
Yeast   457 MNQLIEEWGNSTTKKCFSFCKYPFILSLGIKISIMEYEIRRIMEHEAEQAFLISLDKGKSVDVYF 521

  Fly   651 EIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLF 715
            :|::||..|..||.|.|.. .:.||||: |.:||..|.|:|.|||.:|||:||:|.:|||..|||
Yeast   522 KIKVRRDVISHDSLRCIKE-HQGDLLKS-LRIEFVNEPGIDAGGLRKEWFFLLTKSLFNPMNGLF 584

  Fly   716 EY--------SAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMML 772
            .|        .|:|......:.|.   |.:...|:.| |.:.|:|:::..:||..|.:..||.:.
Yeast   585 IYIKESSRSWFAIDPPNFDKSKGK---NSQLELYYLF-GVVMGLAIFNSTILDLQFPKALYKKLC 645

  Fly   773 QKPIDLKDMESVDTEYYNSLM----WIKENDPRILELTFCLDEDVF--------GQKSQH----- 820
            .:|:..:|...:..|...:|:    :.::|...:..|||   |..:        ..||..
Yeast   646 SEPLSFEDYSELFPETSRNLIKMLNYTEDNFEDVFSLTF---ETTYRNNNWILNDSKSSKEYVTV 707

  Fly   821 ELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSII-PLNLIKIFDEHELELLM 884
            ||...|.|:.:|..||.|::...:|:.....::.|.:.|:.||..:. ..|.||:|:..|||.|:
Yeast   708 ELCENGRNVPITQSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLV 772

  Fly   885 CGIQ---NIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFK 946
            ||.:   ..|.|..|..|.|.|.:..:...:.|||..:.|:...::.:||||||.:.|:|..|..
Yeast   773 CGDEEQTKFDFKSLRSVTKYVGGFSDDSRAVCWFWEIIESWDYPLQKKLLQFVTASDRIPATGIS 837

  Fly   947 ELYGSNGPQMFTIEKWGT--PNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            .:       .|.|...|:  .::.|.||||||.:.|..|....:|:.||:.||..|:|:
Yeast   838 TI-------PFKISLLGSHDSDDLPLAHTCFNEICLWNYSSKKKLELKLLWAINESEGY 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	4/33 (12%)
		WW	581..613	CDD:197736	4/31 (13%)
		HECTc	650..1003	CDD:238033	120/383 (31%)
		HECTc	674..1003	CDD:214523	111/359 (31%)
HUL4	NP_012570.3	HUL4	1..892	CDD:227354	184/774 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810