DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and HUL5

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_011374.1	Gene:	HUL5 / 852736	SGDID:	S000003109	Length:	910	Species:	Saccharomyces cerevisiae

Alignment Length:	435	Identity:	126/435 - (28%)
Similarity:	203/435 - (46%)	Gaps:	57/435 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   586 WEERVHTDGRVFYIDHNTRTTQWEDPRLS---NPNIAGQAVPYSRDYKQKYEYFKSHIRKPTNVP 647
            :||||.    :||:     ....:..|||   :.|:.....|::          .:.:||.:.:
Yeast   513 FEERVD----LFYM-----FIALDKKRLSLDDDHNLINMFTPWA----------STGMRKQSAI- 557

  Fly   648 NKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWV----EFEGETGLDYGGLAREWFYLLSKEMF 708
                  |.|.::|||::...:|:  .:..|..|.|    ||..|.|:|.||:.:|:...:|.|.|
Yeast   558 ------ISRDNVLEDAFNAFNSI--GERFKASLDVTFINEFGEEAGIDGGGITKEFLTTVSDEGF 614

  Fly   709 -NPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMML 772
             :|.:.||..:  |.|.|.   .|.:.:...|.|..|:|::.|..:|...|:|..|...|.|.:|
Yeast   615 KDPKHELFRTN--DRYELY---PSVVYDATKLKYIWFLGKVVGKCLYEHVLIDVSFADFFLKKLL 674

  Fly   773 QKP----IDLKDMESVDTEYYNSLMWI---KENDPRILELTFCLDEDVFGQKSQHELKPGGANID 830
            ...    ....|:.|.|:..||:|:.:   ..::.:.|:|||.:||.....|.. :|.|.|:...
Yeast   675 NYSNGFLSSFSDLGSYDSVLYNNLIKLLNMTTDEIKSLDLTFEIDEPESSAKVV-DLIPNGSKTY 738

  Fly   831 VTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQ-NIDVKD 894
            ||.:|...|:..|.:::...|..:.:|:|..|...||..:.:::|:..||::|:.|.: |||:.|
Yeast   739 VTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIELQMLISGERDNIDLDD 803

  Fly   895 WRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTI 959
            .:.||.|.|....:..|:. ||..:..|..|.:...|:|||...:.|:.|||.|    .|: |.|
Yeast   804 LKSNTEYGGYKEEDQTIVD-FWEVLNEFKFEEKLNFLKFVTSVPQAPLQGFKAL----DPK-FGI 862

  Fly   960 EKWGTPN-NFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            ...||.. ..|.|.||.|.|.||.|.....|::||:.||.....|
Yeast   863 RNAGTEKYRLPTASTCVNLLKLPDYRNKTILREKLLYAINSGARF 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736	6/26 (23%)
		HECTc	650..1003	CDD:238033	112/366 (31%)
		HECTc	674..1003	CDD:214523	106/342 (31%)
HUL5	NP_011374.1	HUL4	35..910	CDD:227354	126/435 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810