DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nedd4 and Nedd4l

DIOPT Version :9

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:XP_036017204.1 Gene:Nedd4l / 83814 MGIID:1933754 Length:1261 Species:Mus musculus


Alignment Length:1204 Identity:489/1204 - (40%)
Similarity:633/1204 - (52%) Gaps:275/1204 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 AAAALPVPSSSSSVAGGDVP-RPPPR------------------------------------RRA 37
            ||..:....|||..:..|.| ..|||                                    .||
Mouse   127 AATRVSAQISSSEPSPVDTPGSSPPRAAWDPGTLVNGTCDHHGQCPHLAEGPEEATPGLRIQHRA 191

  Fly    38 ASVAGQQQTRQEFG-NGYT-PRR-SLAAVNDSGDSCHLRIVVLTGQSLAKKDIFGASDPYVRIDL 99
            :|...:|.....|| :|.. ||| ||..|.|:..|...|..|...|. .::...|          
Mouse   192 SSADVRQVRLLPFGPDGQAEPRRWSLQHVPDASGSSGKRCFVFQLQQ-PQQGALG---------- 245

  Fly   100 NTINGDINIDSVLTK-----------TKKKTLNPTWNEEFIFRVKPSEHK--------------- 138
              :.||.|.....||           .::.|..||  :....||.|:|.:               
Mouse   246 --LTGDFNFGFTGTKGDRLVRYPRIRLERSTSYPT--QPRAGRVSPTEDRGTPEASPRASRVVPE 306

  Fly   139 --------------LVFQV-FDEN------RL----------------------------TRDDF 154
                          .:|:: .|:|      |:                            |||||
Mouse   307 IRRTNSERTPQSPGCMFKIRQDQNAGQQHFRILVTRGPEEAPQNQEETHKSPGHPGAGAPTRDDF 371

  Fly   155 LGMVELTLVNLPTEQEGRTIGEQSYT-----LRPRRSVGAKSRIKGTLRIYHAFIRETREQSEPS 214
            ||.|::.|.:||||....   |:.||     ||||   ..|||:||.||:..|::.:...|.|.:
Mouse   372 LGQVDVPLSHLPTEDPTM---ERPYTFKDFLLRPR---SHKSRVKGFLRLKMAYMPKNGGQDEEN 430

  Fly   215 SGNSDG---EWEHVEATNAGETSAQPHPFPTGGHDALPAGWEERQDANGRTYYVNHTARTTQWDR 276
            |...|.   .||.|::.::.....:..|.|     .||.||||:.|..||||||||..|:|||.|
Mouse   431 SEQRDDMEHGWEVVDSNDSASQHQEELPPP-----PLPPGWEEKVDNLGRTYYVNHNNRSTQWHR 490

  Fly   277 PTVLN-SHSSQSTDDQLASD-----FQRRFHISVD---DTESGRSADSISHNSIEDNNNAAG--- 329
            |:::: |..|.:...|:..:     |:.|.|||.|   :...|.........:|.:..|.||   
Mouse   491 PSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEASEGGGEGPEPWETISEEMNMAGDSL 555

  Fly   330 -LAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQ---DPTVDHTSFVYNSL--RHPVAHR 388
             ||..|        ||.:|      :::.:.|..:||..   ..|.|.....::||  |.| :.|
Mouse   556 SLALPP--------PPASP------VSRTSPQELSEEVSRRLQITPDSNGEQFSSLIQREP-SSR 605

  Fly   389 QPEISATSL---QNDLRPVREAPGVPDIAITNPFTRRA-AGNMAGG-----------------AG 432
            ....|.|..   |..|.|    |..|        |||| :..:.||                 :|
Mouse   606 LRSCSVTDTVAEQAHLPP----PSTP--------TRRARSSTVTGGEESTPSVAYVHTTPGLPSG 658

  Fly   433 WQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVD----------HRQQEPQHRGQRHQQQHRPSN 487
            | :||:..:.:.:...|..|.....:..:.|..|          :...|||.|        ||.:
Mouse   659 W-EERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLVEPQIR--------RPRS 714

  Fly   488 EDTDHTDSHNPSDISAPSTRRNSEEDNAAVP----PMEQNTGGEEEP-----LPPRWSMQVAPNG 543
            ..:.......|.:.:..|..|.:.:|..:.|    |...|:...:..     |||.|.|::||||
Mouse   715 LSSPTVTLSAPLEGAKDSPIRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNG 779

  Fly   544 RTFFIDHASRRTTWIDPR-------NGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDH 601
            |.|||||.::.|||.|||       ..:||..||       ||||||.|||||:|.|||.|||||
Mouse   780 RPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPN-------DLGPLPPGWEERIHLDGRTFYIDH 837

  Fly   602 ------------------NTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPN 648
                              :::.||||||||.||.|.|.||||||::||||:||:..::||.::||
Mouse   838 SSQVLCGENDTRESVPLYDSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPN 902

  Fly   649 KFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYG 713
            :||:::.|.:|.|:|||.|.||.:.|:||.:||:|||.|.||||||:|||||:||||||||||||
Mouse   903 RFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 967

  Fly   714 LFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDL 778
            ||||||.||||||||..||||||:|||||.||||:||:||:||||||.|||||||||||.|.|.|
Mouse   968 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITL 1032

  Fly   779 KDMESVDTEYYNSLMWIKENDPRILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLV 843
            .||||||:||||||.||.||||..|:|.||:||:.|||..|.:|||.|:.|.||||||.|||.||
Mouse  1033 NDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLV 1097

  Fly   844 IEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMN 908
            |:||||.||::||::||:||..::|::|||||||:||||||||:.::||.|||::::||..|..|
Mouse  1098 IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPN 1162

  Fly   909 HIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHT 973
            |.:|||||:|||....|.|.|||||||||||||||||.|||||||||:||||:||:|...|||||
Mouse  1163 HPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHT 1227

  Fly   974 CFNRLDLPPYEGYLQLKDKLIKAIEGSQGFAGVD 1007
            |||||||||||.:..|::||:.|:|.:|||.|||
Mouse  1228 CFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 1261

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 48/212 (23%)
WW 248..277 CDD:278809 19/28 (68%)
WW 531..560 CDD:278809 18/28 (64%)
WW 581..613 CDD:197736 23/49 (47%)
HECTc 650..1003 CDD:238033 244/352 (69%)
HECTc 674..1003 CDD:214523 233/328 (71%)
Nedd4lXP_036017204.1 PHA03378 <107..318 CDD:223065 41/205 (20%)
C2 <367..420 CDD:417471 28/58 (48%)
WW 465..491 CDD:395320 17/25 (68%)
WW 655..684 CDD:395320 6/29 (21%)
WW 768..798 CDD:238122 19/29 (66%)
WW 817..867 CDD:197736 23/49 (47%)
HECTc 928..1257 CDD:214523 233/328 (71%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 465 1.000 Domainoid score I469
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H86986
Inparanoid 1 1.050 880 1.000 Inparanoid score I404
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49869
OrthoDB 1 1.010 - - D142537at33208
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 1 1.000 - - otm43672
orthoMCL 1 0.900 - - OOG6_100256
Panther 1 1.100 - - O PTHR11254
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2273
SonicParanoid 1 1.000 - - X1682
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.870

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