DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and ITCH

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_001244066.1	Gene:	ITCH / 83737	HGNCID:	13890	Length:	903	Species:	Homo sapiens

Alignment Length:	1111	Identity:	346/1111 - (31%)
Similarity:	466/1111 - (41%)	Gaps:	381/1111 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 VNDSGD----------SCHLRIVVLTGQ-SLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTK 116
            ::|||.          ...|:|.|::.: ...||:.||.| |||         ::.:|....||:
Human     1 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPS-PYV---------EVTVDGQSKKTE 55

  Fly   117 K--KTLNPTWNEEFIFRVKPSEHKLVFQVFDENRLTRDDFLG---------------MVELTLVN 164
            |  .|.:|.|.:.....|.|.. ||.|:|:....|..|..||               .:|..:|.
Human    56 KCNNTNSPKWKQPLTVIVTPVS-KLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVT 119

  Fly   165 L-------PTEQEGRTIGEQSYTL-------------------------RPRRS----------- 186
            |       |||    |||:.|..|                         .||..
Human   120 LQLGGDKEPTE----TIGDLSICLDGLQLESEVVTNGETTCSENGVSLCLPRLECNSAISAHCNL 180

  Fly   187 ------------------VGAK-----SRIKGTLRI----------------------------- 199
                              .||.     ||.|...|:
Human   181 CLPGLSDSPISASRVAGFTGASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLSN 245

  Fly   200 --------------------YHAFIRETREQSEPSSGNSDGEWEHVEA---TNAGETS------- 234
                                ..|.:..:...:..|.|:|.|.......   |:.|.||
Human   246 GGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLT 310

  Fly   235 ----AQPHPFPTGGHDALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASD 295
                :.|.|........||.|||:|.|.:||.|||:|..:.|.||||            :.|...
Human   311 ISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP------------EPLPPG 363

  Fly   296 FQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQ 360
            ::||    ||                    |...:.|
Human   364 WERR----VD--------------------NMGRIYY---------------------------- 376

  Fly   361 YRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNPFTRRAAG 425
                      |||                                             |||...
Human   377 ----------VDH---------------------------------------------FTRTTT- 385

  Fly   426 NMAGGAGWQQE-----RRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHRP 485
                   ||:.     |..:|.||...|.|...||..|..|.
Human   386 -------WQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIY----------------------- 420

  Fly   486 SNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDH 550
            .|:|..             :|.::.|.|     |:        .||||.|..:...|||.:|::|
Human   421 GNQDLF-------------ATSQSKEFD-----PL--------GPLPPGWEKRTDSNGRVYFVNH 459

  Fly   551 ASRRTTWIDPRN-GRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPR-- 612
            .:|.|.|.|||: |:.:..            |||||||.|...||..:::|||.|||.:.|||
Human   460 NTRITQWEDPRSQGQLNEK------------PLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTG 512

  Fly   613 ---LSNPNIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTD 674
               |.|    |..:.|.||:|.|.:||:...:: ..:|...:|.:.|.::.|||::.|.|.:..|
Human   513 KSALDN----GPQIAYVRDFKAKVQYFRFWCQQ-LAMPQHIKITVTRKTLFEDSFQQIMSFSPQD 572

  Fly   675 LLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHL 739
             |:.:|||.|.||.||||||:|||||:|||.|:.||.|.||||:..|||.||||..|.: |.:||
Human   573 -LRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHL 635

  Fly   740 SYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEN--DPRI 802
            .||:||||...||::|||.:|..|..||||.:|.||:.|||:||:|.|:||||:|:|||  :...
Human   636 KYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECD 700

  Fly   803 LELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSII 867
            ||:.|.:|:::.|:...|:|||.|.||.||.|||:|||::|.|||....|:||..:|.:||..|:
Human   701 LEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEIL 765

  Fly   868 PLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQ 932
            |...::.||..|||:|:||:|.||:.||:.:.:|: .|......|.|||:.|....||.|.||||
Human   766 PQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYR-HYARTSKQIMWFWQFVKEIDNEKRMRLLQ 829

  Fly   933 FVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAI 997
            |||||.|:|:.||.:|.||||||.|.|||.|..|..||:||||||||||||:.|.|||:||:.||
Human   830 FVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAI 894

  Fly   998 EGSQGF 1003
            |.::||
Human   895 EETEGF 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	48/265 (18%)
		WW	248..277	CDD:278809	16/28 (57%)
		WW	531..560	CDD:278809	12/28 (43%)
		WW	581..613	CDD:197736	19/36 (53%)
		HECTc	650..1003	CDD:238033	187/354 (53%)
		HECTc	674..1003	CDD:214523	180/330 (55%)
ITCH	NP_001244066.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988	38/137 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..301		12/103 (12%)
		WW	328..357	CDD:306827	16/28 (57%)
		HUL4	<359..903	CDD:227354	267/726 (37%)
		Required for interaction with FYN. /evidence=ECO:0000269\|PubMed:16387660	395..471		31/124 (25%)
		MAP kinase docking site. /evidence=ECO:0000250	574..583		4/8 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840