DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and UPL4

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_195908.1	Gene:	UPL4 / 831758	AraportID:	AT5G02880	Length:	1502	Species:	Arabidopsis thaliana

Alignment Length:	447	Identity:	108/447 - (24%)
Similarity:	194/447 - (43%)	Gaps:	100/447 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   613 LSNPNIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLK 677
            ||:.|:.|:|.|.:                 .::|.| :....|.:|||.:.:::......   |
plant  1094 LSSSNVHGEARPVT-----------------GSLPRK-KFLACRENILESAAKMMELYGNQ---K 1137

  Fly   678 TKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLF------------EYSAMDNYTLQINNG 730
            ..:.||:..|.|...|. ..|::.|:|:...||..|::            |:|.:      :.:.
plant  1138 VVIEVEYSEEVGTGLGP-TLEFYTLVSRAFQNPDLGMWRNDCSFIVGKPVEHSGV------LASS 1195

  Fly   731 SGL---------CNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDT 786
            |||         ...:.|..|..:|.:...|:..|::||....:.|||::|.:.:...|:..||.
plant  1196 SGLFPRPWSGTSTTSDVLQKFVLLGTVVAKALQDGRVLDLPLSKAFYKLILGQELSSFDIHFVDP 1260

  Fly   787 EYYNSLMWIK--------------ENDPRILELTF--------CLDEDVFGQKSQHELKPGGANI 829
            |...:|:.::              ::.....:|:|        ||:..:.|. :.::|.|..||.
plant  1261 ELCKTLVELQALVRRKKLFAEAHGDSGAAKCDLSFHGTKIEDLCLEFALPGY-TDYDLAPYSAND 1324

  Fly   830 DVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKD 894
            .|..:|.:||||.::.......:::|:.:|..||..:..:..::||:|.|||.::||
plant  1325 MVNLDNLEEYIKGIVNATVCNGIQKQVEAFRSGFNQVFSIEHLRIFNEEELETMLCG-------- 1381

  Fly   895 WRENTLYKGDYHMNHI-----------IIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKEL 948
              |..|:..:..::||           .:::..:.:..|..|.:...||||||:.|:|..|...|
plant  1382 --ECDLFSMNEVLDHIKFDHGYTSSSPPVEYLLQILHEFDREQQRAFLQFVTGSPRLPHGGLASL 1444

  Fly   949 YGSNGPQMFTIEKWGTPN---NFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQG 1002
                .|::..:.|.|:.:   :.|...||.|.|.||||....::|:|||.||...||
plant  1445 ----SPKLTIVRKHGSDSSDTDLPSVMTCANYLKLPPYSSKEKMKEKLIYAITEGQG 1497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736	108/447 (24%)
		HECTc	650..1003	CDD:238033	100/410 (24%)
		HECTc	674..1003	CDD:214523	96/386 (25%)
UPL4	NP_195908.1	ARM	156..264	CDD:237987
		armadillo repeat	156..181	CDD:293788
		armadillo repeat	189..226	CDD:293788
		armadillo repeat	230..263	CDD:293788
		HEAT repeat	277..303	CDD:293787
		HECTc	1114..1500	CDD:238033	100/409 (24%)
		HECTc	1136..1497	CDD:214523	94/385 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900