DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and AT4G11610

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_192898.2	Gene:	AT4G11610 / 826766	AraportID:	AT4G11610	Length:	1011	Species:	Arabidopsis thaliana

Alignment Length:	836	Identity:	165/836 - (19%)
Similarity:	262/836 - (31%)	Gaps:	294/836 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 LRIVVLTGQSLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKT--KKKTLNPTWNEEFIFRVK- 133
            |.:.|:...:|..||..|.|:.||         ::..|....:|  |.:.|||.|||.|.|.:.
plant     8 LGVDVIGAHNLFPKDGQGTSNAYV---------ELYFDGQKHRTTIKDRDLNPVWNESFFFNISD 63

  Fly   134 PSE-H--KLVFQVFDENRLTRD-DFLGMVELT-----------LVNLPTEQEGRTIGEQSYTLRP 183
            ||. |  .|..|.:..||.|.. .|||.|.|:           :::.|.|:.
plant    64 PSRLHYLNLEAQAYSHNRSTNGRSFLGKVSLSGTSFVPHSDAVVLHFPMERR------------- 115

  Fly   184 RRSVGAKSRIKGT--LRIYHAFIRETREQSEPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGHD 246
                |..||::|.  |::|     .|.|.|..||..|:   :|                |.....
plant   116 ----GIFSRVRGELGLKVY-----ITDEASLKSSAASN---DH----------------PDNLDP 152

  Fly   247 ALPAGW--EERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTES 309
            |||...  |.|.|.....|.:.::|:..|...|...|..||      ||::
plant   153 ALPRAMNVEHRSDKRHVFYNLPNSAQEHQHQHPQGPNQSSS------LAAE-------------- 197

  Fly   310 GRSADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHT 374
                        :||:|.....|.||....                    :.|:|..:...:.|.
plant   198 ------------QDNHNEHHHHYVPKHQVD--------------------EMRSEPARPSKLVHA 230

  Fly   375 SFVYNSLRHPVAHRQP-------------------------EISATS----------LQNDLRPV 404
                    |.:|..||                         :.:|||          |...:...
plant   231 --------HSIASAQPADFALKETSPHLGGGRVVGGRVIHKDKTATSTYDLVERMYFLYVRVVKA 287

  Fly   405 REAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQ 469
            ||.|.:......:||.....||..|                |.:|.:::|..:.|::......|.
plant   288 RELPIMDITGSVDPFVEVRVGNYKG----------------ITRHFEKRQHPEWNQVFAFAKERM 336

  Fly   470 QEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPR 534
            |              .|..:....|.....|......|.:..:....|||        :.||.|:
plant   337 Q--------------ASVLEVVVKDKDLLKDDYVGFVRFDINDVPLRVPP--------DSPLAPQ 379

  Fly   535 WSMQVAPNGRTFFIDHASRRTTWIDPRNGRA-SPMPNQTRRVEDDLGP-LPEGWEERVHTDGRVF 597
            |.......|..  |........||..:...| |...:....:..|..| :......:|:...|::
plant   380 WYRLEDKKGEK--IKGELMLAVWIGTQADEAFSDAWHSDAAMPVDCSPAISAVLRSKVYHAPRLW 442

  Fly   598 YIDHN---------TRTTQWED----PRLSNPNIAG---QAVPYSRDYKQKY-----EYFKSHIR 641
            |:..|         |..|::.|    .:|.|..:..   ||......:.:.:     |.|:.|:.
plant   443 YVRVNVIEAQDLIPTDKTRFPDVYVKAQLGNQVMKTRPCQARTLGAVWNEDFLFVVAEPFEDHLV 507

  Fly   642 KPTN---VPNKFEIRIRRTSILEDSYRIISSVTK--TDLLKTKLWVEFEGETGLDYGGLAREWFY 701
            ....   .|.|.|| :.||      |..:::|.|  .|.:....|...|....:|...|.||
plant   508 LTVEDRVAPGKDEI-VGRT------YIPLNTVEKRADDHMIHARWYNLERPVIVDVDQLKRE--- 562

  Fly   702 LLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLD-----A 761
                                .::::|          ||       |:.....||  :||     :
plant   563 --------------------KFSMRI----------HL-------RVCLEGGYH--VLDESTHYS 588

  Fly   762 FFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRILELTFCLDEDVFGQK 817
            ..:||..:.:.::||.:.::..::..   .|..:|..:.|....|||:.:  :|||
plant   589 SDLRPSARPLWRQPIGVLELGILNAV---GLHPMKTREGRGTSDTFCVGK--YGQK 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	41/151 (27%)
		WW	248..277	CDD:278809	8/30 (27%)
		WW	531..560	CDD:278809	7/28 (25%)
		WW	581..613	CDD:197736	8/45 (18%)
		HECTc	650..1003	CDD:238033	35/175 (20%)
		HECTc	674..1003	CDD:214523	28/149 (19%)
AT4G11610	NP_192898.2	C2A_MCTP_PRT_plant	7..133	CDD:175989	41/155 (26%)
		C2B_MCTP_PRT_plant	279..403	CDD:176024	30/163 (18%)
		C2C_MCTP_PRT_plant	443..593	CDD:175986	36/198 (18%)
		C2D_MCTP_PRT_plant	605..728	CDD:176025	9/40 (23%)
		PRT_C	856..1011	CDD:285560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000