DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and WWC2

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_011530571.1	Gene:	WWC2 / 80014	HGNCID:	24148	Length:	1216	Species:	Homo sapiens

Alignment Length:	417	Identity:	99/417 - (23%)
Similarity:	157/417 - (37%)	Gaps:	119/417 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   520 MEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLG-PLP 583
            |.:..|..:.|||..|......:|:.|:|||.:|||:|||||:....|:     ...|.:| .||
Human     1 MPRRAGSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPL-----SFADCVGDELP 60

  Fly   584 EGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVPYSRDY---------KQKYEYFKSH 639
            .|||........|:||||..:|||.||||   ....|:.....:||         .||..|   |
Human    61 WGWEAGFDPQIGVYYIDHINKTTQIEDPR---KQWRGEQEKMLKDYLSVAQDALRTQKELY---H 119

  Fly   640 IRKPTNVPNKFEIRIRRTSILEDSYRI-----------ISSVTK--TDLLKTKLWVEFEGETGLD 691
            :::     .:..:.:.....|.|:|:.           .||.||  .|:||.::     ..|.|.
Human   120 VKE-----QRLALALDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEI-----STTRLR 174

  Fly   692 YGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHG 756
            ...|.|| ...:.:|:.....|......:|.                    |..|..:|..:...
Human   175 VKKLKRE-LSQMKQELLYKEQGFETLQQIDK--------------------KMSGGQSGYELSEA 218

  Fly   757 K--LLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRILELTFCLDEDVFGQKSQ 819
            |  |.:...||        |.|...:.|..|  ...||..::|.        |.||:::  .:|:
Human   219 KAILTELKSIR--------KAISSGEKEKQD--LMQSLAKLQER--------FHLDQNI--GRSE 263

  Fly   820 HELK---------------PGGANIDVTNE-------NKDEYIKLVIEW----RFVARVKEQMSS 858
            .:|:               ..|:...::.:       |..|.::|.:::    |.:|.:|.::|.
Human   264 PDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEEAKRSMANLKIELSK 328

  Fly   859 FLD-----GFGSIIPLNLIKIFDEHEL 880
             ||     |...|....|:.|.::.||
Human   329 -LDSEAWPGALDIEKEKLMLINEKEEL 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	13/28 (46%)
		WW	581..613	CDD:197736	16/31 (52%)
		HECTc	650..1003	CDD:238033	53/277 (19%)
		HECTc	674..1003	CDD:214523	46/240 (19%)
WWC2	XP_011530571.1	WW	12..41	CDD:278809	13/28 (46%)
		WW	59..88	CDD:278809	14/28 (50%)
		DUF342	<283..385	CDD:302792	16/73 (22%)
		YlqD	351..>428	CDD:287979	2/4 (50%)
		C2_Kibra	700..823	CDD:176062
		vWFA	<1058..>1153	CDD:294047
		Phage_Nu1	<1117..1192	CDD:294991
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900