DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and ube3a

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_001007319.1	Gene:	ube3a / 792398	ZFINID:	ZDB-GENE-041114-190	Length:	857	Species:	Danio rerio

Alignment Length:	1022	Identity:	243/1022 - (23%)
Similarity:	382/1022 - (37%)	Gaps:	286/1022 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 GQSLAKKDIFGASDPYVRIDLNTINGDINIDSV-LTKTKKKTLNPTWNEEFIFRVKPSEHKLVFQ 142
            |......:..|:|..:.|:|    |....|.:: |.|...|..:|          .||: |....
Zfish    22 GNEACTNEACGSSPGFQRMD----NNAAAIKALELYKNNAKLCDP----------HPSK-KGASS 71

  Fly   143 VFDENRL---------------------TRDDFLGMVELT------LVNLPTEQE---------G 171
            .|.||..                     ||:||..:..||      ::::.:|.|         |
Zfish    72 AFPENSAKGAHNFSACSNGKMNHKDLPPTREDFRDLNFLTEDKVYEILSICSETEDYSPLIRVIG 136

  Fly   172 RTIGEQSYTLRPRRSVGAKSRIKGTLRIYHAFIRETRE-QSEPSSGNSDG-EWEHVEATNAGETS 234
            |........::..|.  ||...|..|:...|...:..| :.|.:||:|.. |.|...:.::|:.|
Zfish   137 RVFSSAESLVQSFRK--AKQHTKEELKSLQAKDEDKDEDEKETASGSSTAMEVEPEASASSGDGS 199

  Fly   235 AQPHPFPTGGHDALPAGWEERQ---DANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASD- 295
            :.      |.::....|..|..   ||..|.|                          |:|.|:
Zfish   200 SH------GENNVQKLGPVEVSVDIDAVRRVY--------------------------DRLLSNE 232

  Fly   296 -FQRRFHISVDDTESGRSADSISHN-------------SIEDNNNAAGLAY----TPKTAATSSA 342
             .:..|..::.........|...||             .:.:|:|.....|    .|:.....|
Zfish   233 KIEAAFLNALVYLSPNVECDLTYHNVYAADPNYLNVFIIVMENSNLHSPEYLEIALPQFCKAMS- 296

  Fly   343 PPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRP---V 404
              ..|......||::..||..::               :|..|...|..|:.|.:.|:...   |
Zfish   297 --KLPLPALAKLARLWSQYGVDQ---------------IRRLVETFQQLITYTVISNEFSSDNLV 344

  Fly   405 REAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQ 469
            .|..||  :|.|.........|:.||.                               ||.||
Zfish   345 NEDDGV--VAATKCLKIVYYANVLGGD-------------------------------LDTDH-- 374

  Fly   470 QEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAP----STRRNSEEDNAAVPPMEQNTG----- 525
                             ||:.|.......|:::..    ..|||.:  ...|.|:|...|
Zfish   375 -----------------NEEDDDEPIPESSELTLQELLGEERRNKK--GPRVDPLETEMGIRASD 420

  Fly   526 -------GEE---EPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLG 580
                   .||   |||.....|.   ...|||......:.:::        ..|.....|..:||
Zfish   421 CRKPLIPFEEFINEPLNEVLEMD---KDYTFFKVETESKFSFM--------TCPFILNAVTKNLG 474

  Fly   581 PLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLS--NPNIAGQAV-PYSRDYKQKYEYFKSHIRK 642
                            .|.|:..|  .:.:.|::  ...:.||.: ||.|
Zfish   475 ----------------LYYDNRIR--MYSERRITALYSLVQGQQLNPYLR--------------- 506

  Fly   643 PTNVPNKFEIRIRRTSILEDS---YRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLS 704
                     :::||..|::|:   ..:|:.....| ||.:|:||||||.|:|.||:::|:|.|:.
Zfish   507 ---------LKVRRDHIIDDALVRLEMIAMENPAD-LKKQLYVEFEGEQGVDEGGVSKEFFQLVV 561

  Fly   705 KEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYK 769
            :|:|||..|:|.|.  ::..|...|.|...||   ..|..||.:.|:|:|:..:||..|....|:
Zfish   562 EEIFNPDIGMFTYD--ESTKLFWFNPSSFENE---GQFTLIGIVLGLAIYNNCILDVHFPMVIYR 621

  Fly   770 MMLQKPIDLKDMESVDTEYYNSLMWIKENDPRILE---LTFCLDE-DVFGQKSQHELKPGGANID 830
            .::.|....:|:.......:.||..:.|.:..:.|   :||.:.: |:||....::||..|..|.
Zfish   622 KLMGKKGTFRDLADSHPVLFQSLKDLMEYEGNVEEDMMITFQISQTDLFGNPLMYDLKESGDKIP 686

  Fly   831 VTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIK-IFDEHELELLMCGIQNIDVKD 894
            |||||:.:::.|..|:.....|::|..:|..||..:...:.:| :|...|:|||:||.:|:|.:.
Zfish   687 VTNENRKDFVALYAEYMLNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQA 751

  Fly   895 WRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNG---FKELYGSNGPQM 956
            ..|:|.|.|.|:.:..||:.||..|.||..|.:...|||.|||.|.|:.|   .|.:...|||.
Zfish   752 LEESTEYDGGYNKDSRIIRDFWETVHSFEQEKKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPD- 815

  Fly   957 FTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
                    .:..|.:|||||.|.||.|....:||::|:|||..::||
Zfish   816 --------SDRLPTSHTCFNVLLLPEYSTVEKLKERLLKAITYAKGF 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	33/161 (20%)
		WW	248..277	CDD:278809	6/31 (19%)
		WW	531..560	CDD:278809	5/28 (18%)
		WW	581..613	CDD:197736	3/31 (10%)
		HECTc	650..1003	CDD:238033	123/363 (34%)
		HECTc	674..1003	CDD:214523	118/336 (35%)
ube3a	NP_001007319.1	AZUL	6..60	CDD:293166	10/41 (24%)
		HECTc	505..855	CDD:238033	126/389 (32%)
		HECTc	532..854	CDD:214523	118/336 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810