DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and itch

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_001072737.1	Gene:	itch / 780194	XenbaseID:	XB-GENE-976485	Length:	853	Species:	Xenopus tropicalis

Alignment Length:	1062	Identity:	344/1062 - (32%)
Similarity:	467/1062 - (43%)	Gaps:	323/1062 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 GNGYTPRRSLAAVNDSGDSCHLRIVVLTGQ-SLAKKDIFGASDPYVRIDLNTINGDINIDSVLTK 114
            |:|..|    .|||.......|:::|::.: ...:|:.||.| |||.:   :::|    .|..|:
Frog     3 GSGSRP----GAVNGFTMKSQLQVIVISAKLKDNRKNWFGPS-PYVEL---SVDG----QSKKTE 55

  Fly   115 TKKKTLNPTWNEEFIFRVKPSEHKLVFQVFDENRLTRDDFLGMVELTL---------------VN 164
            ||.||.:|.|.:.....|.|.. .|.|:|:....|..|..:|...|.|               |.
Frog    56 TKNKTHSPKWKQPLTVIVTPFS-VLNFRVWSHQTLKSDALIGSASLNLHETLLSNNMKLEEVIVT 119

  Fly   165 LPTEQEGRTIGEQSYTL-------------RPRRSVGAKSRIKGTLRIYHAFI-----------R 205
            :....:..|:|:.|..|             .|..|.|:.......:....|..           |
Frog   120 MQLLSDRETVGDLSVCLDGMQVDPELLANGDPAVSSGSTDNSSTEVESQAASAESSNGTNSTDSR 184

  Fly   206 ETREQSEPSSGNSDGEWEHVEATNAGETSAQPHPFP-------TGGHDA---------------- 247
            .|...|.||..|..     .:|:.....|..|.|.|       |...:|
Frog   185 TTNGMSSPSLANGG-----FKASRPPRPSRPPPPTPRRASGVVTAISEAPPPPEAELLPTPATAS 244

  Fly   248 ----------------------------------LPAGWEERQDANGRTYYVNHTARTTQWDRPT 278
                                              ||.|||:|.|..||.|||:|.|:.|.||||
Frog   245 LPEAQAPSSTPPVSRQIAPINVDGQRMGLVNQGPLPPGWEQRVDQQGRVYYVDHVAKRTTWDRP- 308

  Fly   279 VLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLAYTPKTAATSSAP 343
                       :.|...::||    ||                    |...:.|
Frog   309 -----------EPLPPGWERR----VD--------------------NMGRIYY----------- 327

  Fly   344 PNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAP 408
                                       |||
Frog   328 ---------------------------VDH----------------------------------- 330

  Fly   409 GVPDIAITNPFTRRAAGNMAGGAGWQQ---ERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQ 470
                  ||...|            ||:   |..|...|..:|::|.:...||.|:..:   :..|
Frog   331 ------ITRTTT------------WQRPTLESVRNYEQWQLQRNQLQGAMQQFNQRFI---YGTQ 374

  Fly   471 EPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRW 535
            |                                ..|.:|.|.|     |:        .|||..|
Frog   375 E--------------------------------TGTTQNKEYD-----PL--------GPLPVGW 394

  Fly   536 SMQVAPNGRTFFIDHASRRTTWIDPRN-GRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYI 599
            ..::..|||.:|::|.:|.|.|.|||| |:.:..            |||||||.|...||..:::
Frog   395 EKRMDGNGRVYFVNHTTRTTQWEDPRNQGQLNEK------------PLPEGWEMRFTVDGIPYFV 447

  Fly   600 DHNTRTTQWEDPR-----LSN-PNIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTS 658
            |||.:||.:.|||     |.| |:||     |.||:|.|.:||:...:: ..:|...:|.:.|.:
Frog   448 DHNRKTTTYIDPRTGKSALDNGPHIA-----YVRDFKAKVQYFRFWCQQ-LYMPQHVKITVNRKT 506

  Fly   659 ILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNY 723
            :.|||::.|.|....| |:.:||:...||.||||||:|||||:|||.|:.||.|.||||:..|||
Frog   507 LFEDSFQQIMSFNAQD-LRRRLWIIIPGEEGLDYGGVAREWFFLLSHEVMNPMYCLFEYAGKDNY 570

  Fly   724 TLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEY 788
            .||||..|.: |.:||.||:||||...||::|||.:|..|..||||.:|.||:.|||:||||.|:
Frog   571 CLQINPASYI-NPDHLRYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESVDPEF 634

  Fly   789 YNSLMWIKENDPRI--LELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVAR 851
            ||||:|||:|:...  ||:.|.:|:::.|....|:|||.|:||.||.|||:|||:||.|||....
Frog   635 YNSLIWIKDNNIEECGLEMFFSVDKEILGDVKSHDLKPDGSNIQVTEENKEEYIRLVAEWRLSRG 699

  Fly   852 VKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFW 916
            |:||..:|.:||..|:|...::.||..|||:|:||:|.||:.||:.||:|: .|......|.|||
Frog   700 VEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRNTIYR-HYTRTSKQIIWFW 763

  Fly   917 RAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLP 981
            :.|....||.|.|||||||||.|:|:.||.:|.||||||.|.|||.|..|..||:||||||||||
Frog   764 QFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLP 828

  Fly   982 PYEGYLQLKDKLIKAIEGSQGF 1003
            ||:.|.|||:||:.|||.::||
Frog   829 PYKSYEQLKEKLLFAIEETEGF 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	37/161 (23%)
		WW	248..277	CDD:278809	17/28 (61%)
		WW	531..560	CDD:278809	11/28 (39%)
		WW	581..613	CDD:197736	18/36 (50%)
		HECTc	650..1003	CDD:238033	189/354 (53%)
		HECTc	674..1003	CDD:214523	182/330 (55%)
itch	NP_001072737.1	C2_E3_ubiquitin_ligase	17..137	CDD:175988	32/128 (25%)
		WW	279..308	CDD:306827	17/28 (61%)
		HUL4	<310..853	CDD:227354	269/725 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910