DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nedd4 and UBE3A

DIOPT Version :10

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:NP_000453.2 Gene:UBE3A / 7337 HGNCID:12496 Length:875 Species:Homo sapiens


Alignment Length:551 Identity:156/551 - (28%)
Similarity:249/551 - (45%) Gaps:103/551 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   489 DTDHT--DSHNPSDISAPST--------RRNSEEDNAAVPPMEQNTGGE----EEPLPPRWSMQV 539
            ||:|.  |...|...|:..|        |||.:  ...|.|:|...|.:    .:||.|......
Human   389 DTNHNEEDDEEPIPESSELTLQELLGEERRNKK--GPRVDPLETELGVKTLDCRKPLIPFEEFIN 451

  Fly   540 AP--------NGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRV 596
            .|        ...|||......:.:::        ..|.....|..:||                
Human   452 EPLNEVLEMDKDYTFFKVETENKFSFM--------TCPFILNAVTKNLG---------------- 492

  Fly   597 FYIDHNTRTTQWEDPRLS--NPNIAGQAV-PYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTS 658
            .|.|:..|  .:.:.|::  ...:.||.: ||.|                        :::||..
Human   493 LYYDNRIR--MYSERRITVLYSLVQGQQLNPYLR------------------------LKVRRDH 531

  Fly   659 ILEDS---YRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAM 720
            |::|:   ..:|:.....| ||.:|:||||||.|:|.||:::|:|.|:.:|:|||..|:|.|.  
Human   532 IIDDALVRLEMIAMENPAD-LKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYD-- 593

  Fly   721 DNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVD 785
            ::..|...|.|....|   ..|..||.:.|:|:|:..:||..|....|:.::.|....:|:....
Human   594 ESTKLFWFNPSSFETE---GQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSH 655

  Fly   786 TEYYNSLMWIKENDPRI---LELTFCLDE-DVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEW 846
            ...|.||..:.|.:..:   :.:||.:.: |:||....::||..|..|.:||||:.|::.|..::
Human   656 PVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDY 720

  Fly   847 RFVARVKEQMSSFLDGFGSIIPLNLIK-IFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHI 910
            .....|::|..:|..||..:...:.:| :|...|:|||:||.:|:|.:...|.|.|.|.|..:.:
Human   721 ILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSV 785

  Fly   911 IIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNG---FKELYGSNGPQMFTIEKWGTPNNFPRAH 972
            :|:.||..|.||::|.:...|||.|||.|.|:.|   .|.:...|||.         ....|.:|
Human   786 LIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPD---------TERLPTSH 841

  Fly   973 TCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            ||||.|.||.|....:||::|:|||..::||
Human   842 TCFNVLLLPEYSSKEKLKERLLKAITYAKGF 872

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999
WW 248..277 CDD:459800
HUL4 <523..1003 CDD:227354 141/505 (28%)
UBE3ANP_000453.2 AZUL 29..83 CDD:465173
HECTc 523..873 CDD:238033 123/389 (32%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.