Protein Alignment Nedd4 and UBE3A

DIOPT Version :9

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: NP_000453.2
• Gene: UBE3A / 7337
• HGNCID: 12496
• Length: 875
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 156/554 - (28%)
• Similarity: 248/554 - (44%)
• Gaps: 109/554 - (19%)

  Fly   489 DTDHT--DSHNPSDISAPST--------RRNSEEDNAAVPPMEQNTGGE---------------E 528
            ||:|.  |...|...|:..|        |||.:  ...|.|:|...|.:               .
Human   389 DTNHNEEDDEEPIPESSELTLQELLGEERRNKK--GPRVDPLETELGVKTLDCRKPLIPFEEFIN 451

  Fly   529 EPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTD 593
            |||.....|.   ...|||......:.:::        ..|.....|..:||
Human   452 EPLNEVLEMD---KDYTFFKVETENKFSFM--------TCPFILNAVTKNLG------------- 492

  Fly   594 GRVFYIDHNTRTTQWEDPRLS--NPNIAGQAV-PYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIR 655
               .|.|:..|  .:.:.|::  ...:.||.: ||.|                        :::|
Human   493 ---LYYDNRIR--MYSERRITVLYSLVQGQQLNPYLR------------------------LKVR 528

  Fly   656 RTSILEDS---YRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEY 717
            |..|::|:   ..:|:.....| ||.:|:||||||.|:|.||:::|:|.|:.:|:|||..|:|.|
Human   529 RDHIIDDALVRLEMIAMENPAD-LKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTY 592

  Fly   718 SAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDME 782
            .  ::..|...|.|....|   ..|..||.:.|:|:|:..:||..|....|:.::.|....:|:.
Human   593 D--ESTKLFWFNPSSFETE---GQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLG 652

  Fly   783 SVDTEYYNSLMWIKENDPRI---LELTFCLDE-DVFGQKSQHELKPGGANIDVTNENKDEYIKLV 843
            ......|.||..:.|.:..:   :.:||.:.: |:||....::||..|..|.:||||:.|::.|.
Human   653 DSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLY 717

  Fly   844 IEWRFVARVKEQMSSFLDGFGSIIPLNLIK-IFDEHELELLMCGIQNIDVKDWRENTLYKGDYHM 907
            .::.....|::|..:|..||..:...:.:| :|...|:|||:||.:|:|.:...|.|.|.|.|..
Human   718 SDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTR 782

  Fly   908 NHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNG---FKELYGSNGPQMFTIEKWGTPNNFP 969
            :.::|:.||..|.||::|.:...|||.|||.|.|:.|   .|.:...|||.         ....|
Human   783 DSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPD---------TERLP 838

  Fly   970 RAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            .:|||||.|.||.|....:||::|:|||..::||
Human   839 TSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	5/28 (18%)
		WW	581..613	CDD:197736	3/31 (10%)
		HECTc	650..1003	CDD:238033	120/363 (33%)
		HECTc	674..1003	CDD:214523	115/336 (34%)
UBE3A	NP_000453.2	AZUL	29..83	CDD:406862
		HECTc	523..873	CDD:238033	123/389 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910