DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and Ubr5

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_006520242.1	Gene:	Ubr5 / 70790	MGIID:	1918040	Length:	2800	Species:	Mus musculus

Alignment Length:	1224	Identity:	255/1224 - (20%)
Similarity:	407/1224 - (33%)	Gaps:	371/1224 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SSSSSVAGGDVPRP---------PPRRRAASVAGQQQTRQEFGNGYTP---------------RR 58
            :::||.|.|....|         |..:||||.|....:        ||               ||
Mouse  1698 TTNSSHANGAAQAPRSMQWAVRNPQHQRAASTAPSSTS--------TPAASSAGLIYIDPSNLRR 1754

  Fly    59 S----------LAAVNDSGDSCHLRIVVLTGQSLAK---------KDIFGASDPYVRIDLNTING 104
            |          .||:..|..|.:|    .:..|||:         .|:.|....|..:..:.|..
Mouse  1755 SGTISTSAAAAAAALEASNASSYL----TSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPA 1815

  Fly   105 DINI---DSV-LTKTKKKTLNPTWNEEFIFRVKPS--------------------EHKLVFQVFD 145
            .:.:   |:| |....::.|.||||  ::..|..|                    .|.|   ...
Mouse  1816 AVKLTYQDAVNLQNYVEEKLIPTWN--WMVSVMDSTEAQLRYGSALASAGDPGHPNHPL---HAS 1875

  Fly   146 ENRLTRDDFLGMVELTLVNLPTEQEGRTIGEQ-----------SYTLRPRRS----------VGA 189
            :|...|:......|.:|..|...:....:..:           :|.|...||          |..
Mouse  1876 QNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLD 1940

  Fly   190 KSRIKGTLRIYHAFI-------------------RETREQSEPSSGNSDGEWEHVEATNAGET-- 233
            ...:|....::.|.|                   :.|||..|....|.|.|.|:.:.|:...|
Mouse  1941 VCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTSQSATLN 2005

  Fly   234 ----------SAQPHPF--------------------PTGGHDALPAGWEERQDANGRTYYVNHT 268
                      :.|.|||                    |..  :|:|..        .:.:.:...
Mouse  2006 DKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLA--EAIPLA--------DQPHLLQPN 2060

  Fly   269 ARTTQ-WDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAG--L 330
            ||... :.||:.....||..:...:......|..:.|..|:...:|:..:..::::.....|  .
Mouse  2061 ARKEDLFGRPSQGLYSSSAGSGKCIVEVTMDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQ 2125

  Fly   331 AYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAE----EDQDPTVDHTSFVYNSLRHPVAHRQPE 391
            :...:.|.:|...|:.|    .:.||:.....||    |.:.|.:  |||            :|:
Mouse  2126 SLLAEEADSSKPGPSAP----DVAAQLKSSLLAEIGLTESEGPPL--TSF------------RPQ 2172

  Fly   392 IS--ATSLQNDL-------------RPVREAPGV-PDIAITNPFTRRAAGNMAGGAGWQQERRRQ 440
            .|  ...:.:|:             |...|..|. |...:|.          .||...::.:.|:
Mouse  2173 CSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTE----------LGGFEVKESKFRR 2227

  Fly   441 QMQLHIQQHQQR----QQQQQQNRILLDVDHRQQEPQHRGQR----HQQQHRP------------ 485
            :|: .::..|.|    :.:..::|.||.....:|...|.|:|    ....||.
Mouse  2228 EME-KLRNQQSRDLSLEVKVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGS 2291

  Fly   486 ---------------SNEDTDHTD----SHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPL 531
                           |||...:.|    ::..:..|.....||..         |::...|.|..
Mouse  2292 GVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQRLRNRG---------ERDRERERERE 2347

  Fly   532 PPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLGPLP---EGWEERVHTD 593
            ..|.|...|.:.|.  .|...||...||.|..|.:...|.:    ||..|||   :...||::.
Mouse  2348 MRRSSGLRAGSRRD--RDRDFRRQLSIDTRPFRPASEGNPS----DDPDPLPAHRQALGERLYP- 2405

  Fly   594 GRVFYIDHNTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRR-- 656
             ||          |...|..:: .|.|..:..|.  .|......|.......|....|:.|..
Mouse  2406 -RV----------QAMQPAFAS-KITGMLLELSP--AQLLLLLASEDSLRARVDEAMELIIAHGR 2456

  Fly   657 ----TSILE----DSYRIIS----------SVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLL 703
                .|||:    ||...:.          ||...||..|        :.|.|...|    ||..
Mouse  2457 ENGADSILDLGLLDSSEKVQENRKRHGSSRSVVDMDLEDT--------DDGDDNAPL----FYQP 2509

  Fly   704 SKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFY 768
            .|..|              ||.:    .|...|..|:.|:.||||.|:.:...:|......|...
Mouse  2510 GKRGF--------------YTPR----PGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVI 2556

  Fly   769 KMMLQKPIDLKDMESVDTEYYNSLMWI----KENDP----RILELTFCLD---EDVFGQKSQHEL 822
            |::|.:.::..|....|...|.||..:    :.:|.    ..::|.|.:|   |:..||.   ||
Mouse  2557 KVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV---EL 2618

  Fly   823 KPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGI 887
            .|.|.||.||.:|..||::...|.|.:...::.:.:...|...::|.|.::.....:..||:.|.
Mouse  2619 IPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGC 2683

  Fly   888 QNIDVKDWRENTLYKGDYHMN-HIIIQ---WFWRAVLSFSNEMRSRLLQFVTGTSRVPMN--GFK 946
            ..::|:.....|.:..:...| ..::|   |||..|...|...|..|:.|.|.:..:|.:  ||:
Mouse  2684 GEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQ 2748

  Fly   947 ELYGSNGPQMFTIEKWGTPN--NFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIE 998
            .:     |.: ||.   .|:  :.|.|:||.:||.:|.|.....||.||:.||:
Mouse  2749 PM-----PSI-TIR---PPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	32/186 (17%)
		WW	248..277	CDD:278809	3/29 (10%)
		WW	531..560	CDD:278809	8/28 (29%)
		WW	581..613	CDD:197736	9/34 (26%)
		HECTc	650..1003	CDD:238033	99/388 (26%)
		HECTc	674..1003	CDD:214523	90/344 (26%)
Ubr5	XP_006520242.1	CUE_UBR5	184..230	CDD:270606
		ZnF_UBR1	1177..1244	CDD:197698
		PolyA	2391..2454	CDD:197769	17/77 (22%)
		HECTc	2469..2797	CDD:214523	94/367 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900