DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nedd4 and Smurf1

DIOPT Version :9

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:XP_006248944.1 Gene:Smurf1 / 690516 RGDID:1594738 Length:757 Species:Rattus norvegicus


Alignment Length:998 Identity:304/998 - (30%)
Similarity:424/998 - (42%) Gaps:310/998 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 SGDSCHLRIVVLTGQSLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTKKKTLNPTWNEEFIF 130
            :|.|..:|:.||..::|||||.|...||:.:|   .::|.....|  |.|.|.||:|.||:.:..
  Rat     9 NGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKI---VVDGSGQCHS--TDTVKNTLDPKWNQHYDL 68

  Fly   131 RVKPSEHKLVFQVFDENRLTRDD---FLGMVELTLVNLPTEQEGRTIGEQSYTLRPRRSVGAKSR 192
            .|..:: .:...|::..::.:..   |||.|.| |.|                        |.||
  Rat    69 YVGKTD-SITISVWNHKKIHKKQGAGFLGCVRL-LSN------------------------AISR 107

  Fly   193 IKGTLRIYHAFIRETREQSEPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGHDALPAGWEERQD 257
            :|.|                                               |:..|..       
  Rat   108 LKDT-----------------------------------------------GYQRLDL------- 118

  Fly   258 ANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIE 322
                                ..||...:.:...|:....|.|..|       |.....:....:.
  Rat   119 --------------------CKLNPSDTDAVRGQIVVSLQTRDRI-------GGGGSVVDCRGLL 156

  Fly   323 DNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAH 387
            :|.   |..|                                ||..|.                 
  Rat   157 ENE---GTVY--------------------------------EDSGPG----------------- 169

  Fly   388 RQPEISATSLQNDLRP---VREAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQH 449
                          ||   :.|.|.        |:| ...|..|||...:..             
  Rat   170 --------------RPLSCLMEEPA--------PYT-DGTGAAAGGGNCRFV------------- 198

  Fly   450 QQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDN 514
               :...|..|:|:   .|.:.|:.||.....|:||.                            
  Rat   199 ---ESPSQDQRLLV---QRLRNPEVRGSLQTPQNRPH---------------------------- 229

  Fly   515 AAVPPMEQNTGGEEEP-LPPRWSMQVAPNGRTFFIDHASRRTTWIDPR----------------- 561
                       |.:.| ||..:..:....|:.:|:...:..:||.|||                 
  Rat   230 -----------GHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPLGTIPGGDEAFLY 283

  Fly   562 ----NGRASPMPNQTRRVE-DDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRL-------- 613
                .|..|. |.....|. |:|||||.|||.|....||::::|||.||||:.||||        
  Rat   284 EFLLQGHTSE-PRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQC 347

  Fly   614 ------------SNPNIAGQAVP---YSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDS 663
                        |..::..:.:|   |.||..||.:..:..:...........|.:.|..|.|:|
  Rat   348 QLKEPSQPLQLPSEGSVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEES 412

  Fly   664 YRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQIN 728
            ||.|..:...| ||.:|.|:|.||.||||||:||||.|||..||.|||||||:||..:.||||||
  Rat   413 YRQIMKMRPKD-LKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQIN 476

  Fly   729 NGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLM 793
            ..|.: |.:|||||.|:|||.|:||:||..::..|..||||.:|.|||.|.|:||||.|.:.||:
  Rat   477 PDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV 540

  Fly   794 WIKEND-PRILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMS 857
            ||.||| ..:|:.|||::.:.||:..||||||.|.|:.||.|||.||::|.:.|||:..::.|..
  Rat   541 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFL 605

  Fly   858 SFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYH--MNHIIIQWFWRAVL 920
            :...||..:||.:|:|.||:.||||::.|:..||:.||:.||..|   |  .:..|::|||:||.
  Rat   606 ALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLK---HCVADSNIVRWFWQAVE 667

  Fly   921 SFSNEMRSRLLQFVTGTSRVPMNGFKELYGSN---GPQMFTIEKW-GTPNNFPRAHTCFNRLDLP 981
            :|..|.|:||||||||::|||:.|||.|.||.   ||::|||... ...:|.|:|||||||:|:|
  Rat   668 TFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIP 732

  Fly   982 PYEGYLQLKDKLIKAIEGSQGFA 1004
            |||.|.:|.:||:.|:|.:.|||
  Rat   733 PYESYEKLYEKLLTAVEETCGFA 755

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 36/135 (27%)
WW 248..277 CDD:278809 1/28 (4%)
WW 531..560 CDD:278809 6/28 (21%)
WW 581..613 CDD:197736 18/31 (58%)
HECTc 650..1003 CDD:238033 183/359 (51%)
HECTc 674..1003 CDD:214523 175/335 (52%)
Smurf1XP_006248944.1 C2_Smurf-like 14..138 CDD:176028 41/228 (18%)
WW 236..267 CDD:197736 8/30 (27%)
WW 307..339 CDD:197736 18/31 (58%)
HECTc 399..754 CDD:238033 183/359 (51%)
HECTc 423..754 CDD:214523 175/335 (52%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100256
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.710

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