DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and Ube3b

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_001137366.1	Gene:	Ube3b / 687633	RGDID:	1583074	Length:	1070	Species:	Rattus norvegicus

Alignment Length:	427	Identity:	135/427 - (31%)
Similarity:	210/427 - (49%)	Gaps:	51/427 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   623 VPYSRDYKQKYEYFKSHIRK----------PTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLK 677
            :|:...:|.:...|::.:.|          .:..|:...|.|||:.:|||.|..:..:.: ..:|
  Rat   646 IPHVVPHKNRVLLFRNMVIKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLPQ-HAMK 709

  Fly   678 TKLWVEFEG-----ETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEE 737
            ..:.|:|..     |.|:|..|:.:|:...:.|.:|:|...||:.::.|.....  :.:...:|.
  Rat   710 GAIRVKFVSDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYP--SPTSYIHEN 772

  Fly   738 HLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMML-------QKPIDLKDMESVDTEYYNSLMWI 795
            :|..|:|:|::.|.|||.|.::|..|...|...||       ...:|  ::.|:|:|:|.:|..|
  Rat   773 YLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSSVD--ELPSLDSEFYKNLTSI 835

  Fly   796 KENDPRI--LELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSS 858
            |..|..:  |.||...||||.||...|||.|||..|.||:|||..||.|:..:|...::|.|.::
  Rat   836 KRYDGDVADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKISYIHLMAHFRMHTQIKNQTAA 900

  Fly   859 FLDGFGSIIPLNLIKIFDEHELELLMCGIQ-NIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLS- 921
            .:.||.|||....|::|...||:.|:.|.. .||::|.:::|:|.|.:|.:|.:|.|.|..:.|
  Rat   901 LISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIVWLWDILASD 965

  Fly   922 FSNEMRSRLLQFVTGTSRVPMNGFKEL--------------------YGSNGPQMFTIEKWGTPN 966
            |:...|:..|:|||..||.|:.||..|                    .||.....|||.|.....
  Rat   966 FTPGERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGG 1030

  Fly   967 NFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            ..|.:.||||.|.||.|.....|::||..||..:.||
  Rat  1031 RLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736
		HECTc	650..1003	CDD:238033	128/388 (33%)
		HECTc	674..1003	CDD:214523	120/364 (33%)
Ube3b	NP_001137366.1	HECTc	684..1068	CDD:238033	130/389 (33%)
Ube3b	NP_001137366.1	HECTc	709..1067	CDD:214523	120/361 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810