DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nedd4 and Arel1

DIOPT Version :9

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:NP_001351118.1 Gene:Arel1 / 68497 MGIID:1915747 Length:823 Species:Mus musculus


Alignment Length:572 Identity:169/572 - (29%)
Similarity:268/572 - (46%) Gaps:82/572 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   462 LLDVDHRQQEPQHRGQRH--QQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNT 524
            |.:.::....|.|....|  ..|.|||.. .:..|..:||:...|...:..::....|.|.:.:.
Mouse   301 LYNANNCTSTPWHLPPMHMSSSQRRPSTA-IEEDDEDSPSECHTPEKVKKPKKVYCYVSPKQFSV 364

  Fly   525 GGEE---EPLPPR-WSMQVAPNGRTFFI--DHASRRTTWIDPRNGRASPMPNQTRRVEDDLGPLP 583
              :|   :.:|.| ::.:|.|..:..::  |...:..|.:                |:|.:.|..
Mouse   365 --KEFYLKIIPWRLYTFRVCPGTKFSYLGPDPVHKLLTLV----------------VDDGIQPPV 411

  Fly   584 E-GWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYEYFKS-----HIRK 642
            | ..:||            |.....:  .|..:.||.|     |..::.|..:|:.     |:::
Mouse   412 ELSCKER------------NILAATF--IRSLHKNIGG-----SETFQDKVNFFQRELRQVHMKR 457

  Fly   643 PTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEM 707
            |   .:|..:::.|.::||.|.:...:.:.:|..| ...|.|:.|..||:||..||||.|:.|.:
Mouse   458 P---HSKVTLKVSRHALLESSLKATRNFSISDWSK-NFEVVFQDEEALDWGGPRREWFELICKAL 518

  Fly   708 FNPYYGLFEYSAMDNYTLQINNGSGLCNEEH--LSYFKFIGRIAGMAVYHGKLLDAF-------F 763
            |:....||......|..|...|.:   ...|  |..::|.||:.|..:|...|..|:       |
Mouse   519 FDTTSQLFARFTDSNQALVHPNPN---RPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARF 580

  Fly   764 IRPFYKMMLQKPIDLKDMESVDTEYYNS-LMWIKENDPRILELTFCLDEDVFGQKSQ----HELK 823
            .|.|...::...:..|..|:.|.|:|.| :.:|..||...:||.|.  |:.:.:..|    .||.
Mouse   581 TRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEMELVFA--EEKYNKSGQLDKIVELM 643

  Fly   824 PGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQ 888
            .|||...|||.||..|:.|:.::|..::|||::..||.|...::|.||:.||||:||||||||..
Mouse   644 TGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTG 708

  Fly   889 NIDVKDWREN-TLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSN 952
            :|:|.|::.: .:..|.:|....:::|||..|.|.:.|..:|||||.||:|::|..||..|..| 
Mouse   709 DINVSDFKAHAVVVGGSWHFREKVMRWFWAVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS- 772

  Fly   953 GPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAI-EGSQGF 1003
                |.|....|.:..|.||||||:|.||.|:.|.::...|..|| ||.:||
Mouse   773 ----FQIIAAPTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999
WW 248..277 CDD:278809
WW 531..560 CDD:278809 6/31 (19%)
WW 581..613 CDD:197736 5/32 (16%)
HECTc 650..1003 CDD:238033 129/368 (35%)
HECTc 674..1003 CDD:214523 125/344 (36%)
Arel1NP_001351118.1 Filamin 56..154 CDD:395505
Filamin 64..158
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 315..345 8/30 (27%)
HECTc 464..821 CDD:238033 131/368 (36%)
Interaction with SOCS2. /evidence=ECO:0000250|UniProtKB:O15033 483..789 110/316 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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