DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and Wwp2

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_080106.1	Gene:	Wwp2 / 66894	MGIID:	1914144	Length:	870	Species:	Mus musculus

Alignment Length:	1026	Identity:	318/1026 - (30%)
Similarity:	445/1026 - (43%)	Gaps:	328/1026 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 DINIDSVLTKTKK--KTLNPT---WNEEFIFRVKPSEHKLVFQVFDENRLTRDDFLGMVELTL-- 162
            ::.:|.:.::|||  |.:..:   |||..:..|....| |..:|:..:.| |::.||...:.|
Mouse    43 EVAVDGLPSETKKTGKRIGSSELLWNEIIVLNVTAQSH-LDLKVWSCHTL-RNELLGTASVNLSN 105

  Fly   163 ---------------VNLPTEQEGRTI--GE---------------------------------- 176
                           :||.||.:|..:  ||
Mouse   106 VLKNNGGKMENTQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGSVPNGSAVTDGSQPPSRESSG 170

  Fly   177 -------------------------------QSYTLRPRRSVGAKSR-------------IKGTL 197
                                           ::.|....:|.||::|             ..||:
Mouse   171 TAIAPETRHQPPSTNCFGGRSRTHRHSGGSARTATAASEQSPGARNRHRQPVKNSSSSGLANGTV 235

  Fly   198 RIYHAFIRETRE----------------QSEPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGHD 246
            ........|..|                .|.|::.:...:....|...|..:..|..|......|
Mouse   236 NEEPTPASEPEESSVVGVTSLPAAALSVSSNPNTTSLPAQSTPAEGEEASTSGTQQLPAAAQAPD 300

  Fly   247 ALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGR 311
            |||||||:|:..|||.|||:|..:||.|:||
Mouse   301 ALPAGWEQRELPNGRVYYVDHNTKTTTWERP---------------------------------- 331

  Fly   312 SADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPT-----V 371
                                          .||..                 |:..||.     |
Mouse   332 ------------------------------LPPGW-----------------EKRTDPRGRFYYV 349

  Fly   372 DHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNPFTRRAAGNMAGGAGWQQE 436
            ||.:                 ..|:.|   ||..|
Mouse   350 DHNT-----------------RTTTWQ---RPTAE------------------------------ 364

  Fly   437 RRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDI 501
                    :::.::|.|.|:.|         .|...||..||...|  .|:..|||
Mouse   365 --------YVRNYEQWQSQRNQ---------LQGAMQHFSQRFLYQ--SSSASTDH--------- 401

  Fly   502 SAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRAS 566
                            .|:        .||||.|..: ..|||.::::|.:|.|.|.|||.....
Mouse   402 ----------------DPL--------GPLPPGWEKR-QDNGRVYYVNHNTRTTQWEDPRTQGMI 441

  Fly   567 PMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVP--YSRDY 629
            ..|           .||.|||.:..::|..:::|||||||.::|||....:...|..|  |.|.:
Mouse   442 QEP-----------ALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSF 495

  Fly   630 KQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGG 694
            :.||..|: .:.....:|:..:|.:.|.::.|||::.|.::...| |:.:|::...||.||||||
Mouse   496 RWKYHQFR-FLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGG 558

  Fly   695 LAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLL 759
            :|||||:|||.|:.||.|.||||:..:||.||||..|.: |.:||:||:||||...||:||||.:
Mouse   559 IAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 622

  Fly   760 DAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRI--LELTFCLDEDVFGQKSQHEL 822
            |..|..||||.||.|...|||:||:|.|:|||::|||||:...  |||.|..|.::.|:.:.|||
Mouse   623 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELFFIQDMEILGKVTTHEL 687

  Fly   823 KPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGI 887
            |.||.||.||.|||:|||.|:.:|||...|:||..:|||||..:.||..::.|||.||||::||:
Mouse   688 KEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGM 752

  Fly   888 QNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSN 952
            |.||:.||::|.:|: .|..:...|||||:.|....||.|.|||||||||.|:|:.||.||.|||
Mouse   753 QEIDMSDWQKNAIYR-HYTKSSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSN 816

  Fly   953 GPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            |||.|.|::.|.....||:||||||||||||:.|.|||:||:.|||.::||
Mouse   817 GPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGF 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	31/200 (16%)
		WW	248..277	CDD:278809	17/28 (61%)
		WW	531..560	CDD:278809	11/28 (39%)
		WW	581..613	CDD:197736	15/31 (48%)
		HECTc	650..1003	CDD:238033	188/354 (53%)
		HECTc	674..1003	CDD:214523	182/330 (55%)
Wwp2	NP_080106.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988	24/100 (24%)
		PRK07003	<149..>299	CDD:235906	15/149 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..300		15/149 (10%)
		WW	302..331	CDD:366073	17/28 (61%)
		WW	332..361	CDD:366073	10/65 (15%)
		WW	407..435	CDD:366073	11/28 (39%)
		WW	447..477	CDD:238122	14/29 (48%)
		HECTc	516..868	CDD:238033	190/355 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11382
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740