DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and nedd4a

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_001029358.1	Gene:	nedd4a / 619412	ZFINID:	ZDB-GENE-051005-2	Length:	910	Species:	Danio rerio

Alignment Length:	991	Identity:	476/991 - (48%)
Similarity:	600/991 - (60%)	Gaps:	144/991 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 DSGDSCHLRIVVLTGQSLAKKDIFGASDPYVRIDL-NTINGDINIDSVLTKTKKKTLNPTWNEEF 128
            |..:|..||:.::.|..||||||.||||||.||.| :.:||:|.  |:.|||.||||:|.|||||
Zfish    16 DEDESRILRVKIIAGIGLAKKDILGASDPYTRISLYDPVNGEIT--SLQTKTIKKTLDPKWNEEF 78

  Fly   129 IFRVKPSEHKLVFQVFDENRLTRDDFLGMVELTLVNLPTEQEGRTIGEQSYT-----LRPRRSVG 188
            .|||.|..|:|:.:||||||||||||||.|::.|..:|||...   .|:.||     |.||   .
Zfish    79 FFRVHPRRHRLLLEVFDENRLTRDDFLGQVDVPLHQIPTEHPN---NERPYTFKDFLLHPR---S 137

  Fly   189 AKSRIKGTLRIYHAFIRETR-------EQSEPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGHD 246
            .|||:||.||:...::.:.|       ||.|    |.|..||.:|..... :...||..|
Zfish   138 HKSRVKGHLRLKMTYLPKNRRCKDDPAEQGE----NLDPGWEFLEPHELC-SPHHPHQLP----- 192

  Fly   247 ALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRF----------- 300
            |||.|||||||..||||||||.:|||||.|||:.:|........:..|:.||.|
Zfish   193 ALPPGWEERQDNLGRTYYVNHESRTTQWHRPTIQDSQRDNEQRQETHSESQRAFLTRRQISEHEE 257

  Fly   301 -HISVDDTESGR--SAD-SISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQY 361
             |...:..||..  :|| |..::|:.:.               |..||::|...:....:. .:.
Zfish   258 NHERRESPESWEIITADESTLYSSLSER---------------SPPPPHSPMEISTFCEEF-NRL 306

  Fly   362 RAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNPFTRRAAGN 426
            :|..|:     .||..            |:::|.:.:.| ||.|..    .|..|:.....:||.
Zfish   307 QATNDR-----RTSLT------------PQVTAAAEEVD-RPSRWR----SILFTHSLLPTSAGL 349

  Fly   427 MAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTD 491
               ..|| :|::..:.:::...|..|.....:..|.|     .|.|
Zfish   350 ---PPGW-EEKQDSKGRIYFVNHNSRTTTWTRPLIQL-----IQPP------------------- 386

  Fly   492 HTDSHNP-SDISAPSTRRNSEEDNAAVPP--------MEQNTGGEEEP--LPPRWSMQVAPNGRT 545
               |.:| |.:::.||..:......|:||        ...:|...|.|  :|..|.::.||:||.
Zfish   387 ---SESPASPMASGSTSLSQNAAGYALPPDVSPQHTHTHTHTHTPEHPGLMPTGWEVRSAPSGRP 448

  Fly   546 FFIDHASRRTTWIDPRNGRASPMPNQTRR----VEDDLGPLPEGWEER--VHTDGRVFYI---DH 601
            |||||.::.|||.|||    ..:|.|.||    ...||||||.|||..  |..:......   .|
Zfish   449 FFIDHNTKTTTWDDPR----LKVPVQMRRRVSLDPTDLGPLPPGWESECIVMAESSTLITTQKPH 509

  Fly   602 NTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRI 666
            |.:|   .|.|: .|:: |.|||||||||||||||:..::||..:||:||:.:||.::||||||.
Zfish   510 NGKT---HDYRI-QPSL-GPAVPYSRDYKQKYEYFRKKLKKPAEIPNRFELSVRRNAVLEDSYRR 569

  Fly   667 ISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGS 731
            |.||.:::|||.:||||||||.||||||:|||||:|:||||||||||||||||.||||||||..|
Zfish   570 ILSVKRSELLKARLWVEFEGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNS 634

  Fly   732 GLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIK 796
            |||||:||||||||||:||||||||||||||||||||||||||||.|:||||||:||:|||.||.
Zfish   635 GLCNEDHLSYFKFIGRVAGMAVYHGKLLDAFFIRPFYKMMLQKPITLQDMESVDSEYFNSLRWIL 699

  Fly   797 ENDPRILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLD 861
            ||||..|:|.|.:||::|||..|||||||||:|.|.:.||.|||.||::||||.|::.||::|.:
Zfish   700 ENDPTDLDLRFTIDEELFGQTHQHELKPGGADIVVNDTNKKEYIHLVMQWRFVDRIQRQMTAFKE 764

  Fly   862 GFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEM 926
            ||..:||.:|||||||:||||||||:.::||.||||||.||..|:.||..|.|||:.||....|.
Zfish   765 GFYELIPQDLIKIFDENELELLMCGLGDVDVNDWRENTKYKNGYNPNHPAIIWFWKTVLLMDAEK 829

  Fly   927 RSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKD 991
            |.|||||||||||||||||.|||||||||:||||:|||....||||||||||||||.|.:.:|::
Zfish   830 RIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGTREKLPRAHTCFNRLDLPPXESFEELRE 894

  Fly   992 KLIKAIEGSQGFAGVD 1007
            ||..|||.:|||.|||
Zfish   895 KLHMAIENAQGFDGVD 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	73/138 (53%)
		WW	248..277	CDD:278809	22/28 (79%)
		WW	531..560	CDD:278809	14/28 (50%)
		WW	581..613	CDD:197736	11/36 (31%)
		HECTc	650..1003	CDD:238033	251/352 (71%)
		HECTc	674..1003	CDD:214523	238/328 (73%)
nedd4a	NP_001029358.1	C2_NEDD4_NEDD4L	22..153	CDD:175999	73/138 (53%)
		WW	194..223	CDD:366073	22/28 (79%)
		WW	349..378	CDD:366073	5/32 (16%)
		WW	435..465	CDD:238122	17/33 (52%)
		HECTc	577..906	CDD:214523	238/328 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	135	1.000	Domainoid score	I4924
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	861	1.000	Inparanoid score	I410
OMA	1	1.010	-	-		QHG49869
OrthoDB	1	1.010	-	-		D142537at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm25407
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1682
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980