DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and Huwe1

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_006528996.1	Gene:	Huwe1 / 59026	MGIID:	1926884	Length:	4456	Species:	Mus musculus

Alignment Length:	998	Identity:	292/998 - (29%)
Similarity:	420/998 - (42%)	Gaps:	207/998 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 PTEQEGRTIGEQSYTL-RP--RRSVGAKSRIKGTLRIYHAFIRETR----EQSEPSSGNSDGEWE 223
            |...|...:|:....| .|  |||.....::...|.:....:.|.:    :.:..:||:|.....
Mouse  3503 PHSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENKVSEVQTNSSNSGSSTAATS 3567

  Fly   224 HVEATNAGETSAQPHPFPTGGHDALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQST 288
            :...|....|:|.. |.||......|........|......:...|.||. ..||...:..|.||
Mouse  3568 NTSTTTTTTTTATA-PTPTPPAATTPVTSAPALVAATAISTITVAASTTV-TTPTTATTTVSTST 3630

  Fly   289 DDQLAS-----------DF--------QRRFHISVDDTESGRSADSISHNSIEDN---------- 324
            .....|           ||        :.:..:||:...|    .|.|...:||.
Mouse  3631 TKGSKSPAKVGEGGSGIDFKMVSSGLTENQLQLSVEVLTS----HSCSEEGLEDAANVLLQLSRG 3691

  Fly   325 -------------NNAAGLAYT-PKTAATSSAPPNTPTNNNGILAQ-----IAMQYRAE------ 364
                         |.|..|.|| .|...|             :||:     :..|.||:
Mouse  3692 DSGTRDTVLKLLLNGARHLGYTLCKQIGT-------------LLAELREYNLEQQRRAQCETLSP 3743

  Fly   365 ----EDQDPT------------VDHTSFVYNSLRHPVAHRQPEI-------SATSLQNDLRPVRE 406
                |:|..|            :.....:..|.:.|:..|:.::       |.||.|.....|.:
Mouse  3744 DGLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTSTQKFFLRVLQ 3808

  Fly   407 APGVPDIAITNPFTRRA--AGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQ 469
            .     |......||||  .....|..|.........:|..:     ||.:.:.:.|:..|
Mouse  3809 V-----IIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAV-----RQLEAEADAIIQMV---- 3859

  Fly   470 QEPQHRGQR-HQQQHRPSNEDTDHTDS-----HNPSDISAPSTRRNSEEDNAAVPPMEQNTGG-- 526
                ..||| .:||...::|.::.:::     .:|.|:..||.   |.:|..::...:....|
Mouse  3860 ----REGQRARRQQQAATSESSNQSETSVRREESPMDVDQPSP---SAQDTQSIVISDGTPQGEK 3917

  Fly   527 EEEPLPPR-------------WSM------------------QVAPNGRTFFIDHASRRTTWIDP 560
            |:|..||.             |.|                  .:.|....||:.||:.|.:....
Mouse  3918 EKEEKPPELPLLSEQLSLDELWDMLGECLKELEESHDQHAVLVLQPAVEAFFLVHATERESKPPV 3982

  Fly   561 RNGRASPMPNQTRRVEDDLGPL---------PEGWEERVHTDGRVFYIDHNT------------- 603
            |:.|.|    |...::|:..||         |...:.....:....:|..:.
Mouse  3983 RDTRES----QLAHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAET 4043

  Fly   604 -RTTQWEDPRLSNPNIA----GQAVPYSR--DYKQKYEYFKSHIRKPTNVPNK--FEIRIRRTSI 659
             ||...:..|.|..::|    ...|.|.|  |:..|.:||:..:.:......|  ..:.:||..:
Mouse  4044 HRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHV 4108

  Fly   660 LEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYT 724
            .|||||.:...:..: :|.:|::.||||.|.|.|||.|||:.::|:|||||.|.||..|..|..|
Mouse  4109 FEDSYRELHRKSPEE-MKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVT 4172

  Fly   725 LQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYY 789
            ..||..|. ||..|||||||:|||...|||..:||:.:|.|.|||.:|.|.:...||||.|..:|
Mouse  4173 YTINPSSH-CNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFY 4236

  Fly   790 NSLMWIKENDPRIL--ELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARV 852
            ..|:::.|||...|  :|||..:...||.....:|||.||||.||.|||.||:.||.:.|....:
Mouse  4237 QGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAI 4301

  Fly   853 KEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWR 917
            ::|:::||:||..|||..||.||.|.|||||:.|:..||:.|.:.||.|. .|..|.|.||||||
Mouse  4302 RKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYH-KYQSNSIQIQWFWR 4365

  Fly   918 AVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWG-TPNNFPRAHTCFNRLDLP 981
            |:.||....|::.||||||||:||:.||..|.|.||.|.|.|.:.. :.:..|.||||||:||||
Mouse  4366 ALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLP 4430

  Fly   982 PYEGYLQLKDKLIKAI-EGSQGF 1003
            .||.:.:|:..|:.|| |.|:||
Mouse  4431 AYESFEKLRHMLLLAIQECSEGF 4453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	9/40 (23%)
		WW	248..277	CDD:278809	5/28 (18%)
		WW	531..560	CDD:278809	10/59 (17%)
		WW	581..613	CDD:197736	6/54 (11%)
		HECTc	650..1003	CDD:238033	169/356 (47%)
		HECTc	674..1003	CDD:214523	162/332 (49%)
Huwe1	XP_006528996.1	DUF908	92..367	CDD:399185
		DUF913	431..892	CDD:399192
		UBA_HUWE1	1395..1434	CDD:270474
		WWE	1695..1756	CDD:397111
		fibronec_FbpA	<2809..>2992	CDD:411474
		DUF4414	3044..3071	CDD:405126
		DUF4414	3089..3120	CDD:405126
		HECTc	4101..4454	CDD:238033	171/356 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810