DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and plekha5

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_021330752.1	Gene:	plekha5 / 567300	ZFINID:	ZDB-GENE-041210-25	Length:	1398	Species:	Danio rerio

Alignment Length:	309	Identity:	68/309 - (22%)
Similarity:	109/309 - (35%)	Gaps:	90/309 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   531 LPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGR 595
            ||..||..|..:||.|||:..::.|||:.|..|.|  :....|:..|    ||.||||....:|.
Zfish    13 LPSSWSYGVTRDGRVFFINEEAKSTTWLHPVTGEA--VITGHRKTPD----LPTGWEEGYTFEGA 71

  Fly   596 VFYIDHNTRTTQWEDP---------------------RLSNPNIAGQAV----------PYS--- 626
            ..:|:||.|....:.|                     .|.:|.::..|.          |.|
Zfish    72 RCFINHNERKVTCKHPVSGVPSQDNCIFVVNEHLNCGNLVHPVLSRPATKAPEAEKKERPTSTMS 136

  Fly   627 --RDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETG 689
              .:|....:| .:|...||..|::...::.......:|   |.......::|.. |:..:..||
Zfish   137 EASNYTGGSDY-TTHPSSPTTRPSRSSKKVHNFGKRSNS---IKRNPNAPVIKNG-WLHKQDSTG 196

  Fly   690 LDYGGLAREWFYLLSKEMFNPYY------GLFEYSAMDNYTLQINNGSGLCNEEHLS-YFKFIGR 747
            :..  ..:.||.|....:|  ||      |:.....:.::.:     |.|..::|:: .:.|...
Zfish   197 MKM--WKKRWFVLSDMCLF--YYRDEKEEGILGSILLPSFHI-----SMLSVDDHITRKYAFKAT 252

  Fly   748 IAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIK 796
            ...|..|:.....|                 |||||          |:|
Zfish   253 HPNMRTYYFSTDTA-----------------KDMES----------WMK 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	13/28 (46%)
		WW	581..613	CDD:197736	12/52 (23%)
		HECTc	650..1003	CDD:238033	27/154 (18%)
		HECTc	674..1003	CDD:214523	25/130 (19%)
plekha5	XP_021330752.1	WW	13..42	CDD:306827	13/28 (46%)
		WW	58..87	CDD:306827	11/28 (39%)
		PH_PEPP1_2_3	177..280	CDD:270068	25/135 (19%)
		SMC_N	822..>983	CDD:330553
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900