DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and wwc3

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_001103940.1	Gene:	wwc3 / 566492	ZFINID:	ZDB-GENE-070209-229	Length:	1148	Species:	Danio rerio

Alignment Length:	447	Identity:	102/447 - (22%)
Similarity:	159/447 - (35%)	Gaps:	146/447 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   528 EEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLG-PLPEGWEERVH 591
            |.||||.|......:||.|:|||.:|:|:|||||:....|:     ...|.:| .||.|||....
Zfish    14 ELPLPPGWEEARDYDGRVFYIDHNTRQTSWIDPRDRITKPL-----TFADCVGDELPLGWEVVYD 73

  Fly   592 TDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYE-YFKSHI---RKPTNVPNK-FE 651
            ....|:||||..:|||.|:||              ..::|:.| ..|.::   ::..|...: ::
Zfish    74 QQVGVYYIDHINKTTQIENPR--------------TQWRQEQERMLKEYLVVAQEALNAKKEMYQ 124

  Fly   652 IRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFE 716
            |:.:|..:.:...::.:.:|:.|  ...:.....|.:               |...::|
Zfish   125 IKQQRLELAQQEMQLFNQLTQDD--NRSITSSHSGSS---------------SNAKYDP------ 166

  Fly   717 YSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMM----LQKPID 777
                |....:|     .|..|.||..|     ..:|....:|.        ||.|    ||: ||
Zfish   167 ----DQIKAEI-----ACRRERLSRLK-----QELAQMRQELQ--------YKEMGVETLQE-ID 208

  Fly   778 LKDMESVDTEY--------YNSLMWI--------KENDPRI-----LELTFCLD--------EDV 813
            .| |.|..|.|        ::.|..|        ||....|     |.|.||..        |.:
Zfish   209 RK-MSSSQTNYKLDEAQAIFSELRSIKKAISTGEKERQDLIQSLAKLTLNFCDSINEVTNNAESL 272

  Fly   814 FGQKSQHELKPGGANIDVTNENKDEYIKLV-----IEWRFVARVKEQMSSFLDGFGSIIPLNLIK 873
            ....|..:....|...|:..|...:...|:     :.|:: ...|::|||.
Zfish   273 ADSCSVQQYTDAGCQTDLMGEFGSQESSLLADRVKLSWQY-EEAKKKMSSI-------------- 322

  Fly   874 IFDEHELELL----MCGIQNIDVKDW-------------RENTLYKGDYHMNHIIIQ 913
               :|:|..|    ..|....| :||             :|.||.....|.:..::|
Zfish   323 ---QHQLAQLDSESWSGRAEAD-RDWDCLQLLREKETLLQELTLLSQQQHSSDTLLQ 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	14/28 (50%)
		WW	581..613	CDD:197736	15/31 (48%)
		HECTc	650..1003	CDD:238033	60/319 (19%)
		HECTc	674..1003	CDD:214523	57/295 (19%)
wwc3	NP_001103940.1	WW	17..46	CDD:278809	14/28 (50%)
		WW	64..93	CDD:278809	14/28 (50%)
		C2_Kibra	677..800	CDD:176062
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900