DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and trip12

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_005159283.1	Gene:	trip12 / 564866	ZFINID:	ZDB-GENE-041111-262	Length:	2096	Species:	Danio rerio

Alignment Length:	1044	Identity:	217/1044 - (20%)
Similarity:	366/1044 - (35%)	Gaps:	338/1044 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 TVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISH-------------------NSIED 323
            |...:.:|..|.|..:..||.....|:|.:..||.:|.:..                   :.:::
Zfish  1070 TATTTAASNVTPDLGSPSFQHSMDDSLDLSPQGRLSDVLKRKRLPKRGPRRPKYSPPRDDDKVDN 1134

  Fly   324 NNNAAGLAYTPKTAATSSAPPNT--------------PTNNNGI--LAQIAMQYRAEEDQD---- 368
            ...:.....:||::..:|..|.|              |:...|:  ||::..:.....::|
Zfish  1135 QAKSPTTTQSPKSSFLASLNPKTWGKLGTQANSANSEPSRTAGVSGLARVPPKDSVSNNRDKIKA 1199

  Fly   369 ----------------PTVDHTSFVYNSL-RHPVAHRQ------------PEISATSLQNDLR-- 402
                            .:||.::...|.| |...|..|            .|||:...::|:.
Zfish  1200 WIKEQASKFVERYFNSESVDGSNPALNVLQRLCTATEQLNLQMDSGVECLEEISSIVSESDVSSF 1264

  Fly   403 ------------------------------------------PVREAPGVPDIAITNPFTRRA-- 423
                                                      |.:|.||..|.....|.....
Zfish  1265 EIQHSGLVKQLLLYLTSNSERDTISRDERIKRFLHVFFGCPIPGQEPPGRLDPTENGPLLALVHK 1329

  Fly   424 -------------------AGNMAGGAGWQQER--RRQQMQLHIQQHQQRQQQQQQNRILLDVDH 467
                               :||..|..|.|..:  ...|::..:|:|......:|.....:.:|.
Zfish  1330 MNNCLSQMEQFPVKVHDFPSGNGNGSRGSQALKFFNTHQLKCQLQRHPDCTNVKQWKGGPVKIDP 1394

  Fly   468 R---QQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEE 529
            .   |...::...|...:.|..:||:|...|.:..|.|..:...||    .:|....|...||.
Zfish  1395 LALVQAIERYLVVRGYGRIREEDEDSDDDGSDDEIDESLAAQFLNS----GSVRHRLQFYIGEH- 1454

  Fly   530 PLPPRWSMQVAPNGRTFFIDHASRR--------------------TTWIDP-------------- 560
             |.| ::|.|....|.|.:.....|                    |.|..|
Zfish  1455 -LLP-YNMTVYQAVRQFSLQAEEERESTDDEANPLGRAGIWTKTHTVWYKPVREDEEGCKDAVGG 1517

  Fly   561 RNGRASPMPNQT----RRVEDDL----------GPL--------PEG--WEE---------RV-H 591
            :.|||...|.:|    .:.:|:|          .||        |||  :::         || |
Zfish  1518 KRGRAQTAPTKTSPRNAKKQDELWHEGVCPSVANPLETYLICDPPEGITFDDPSMEVILLLRVLH 1582

  Fly   592 TDGRV-FYI-DH-------------NTRTTQWEDPRLSNP------NI------AGQAVP--YSR 627
            :..|. ||: |:             |::.|...:.:|.:|      ||      .|:..|  :..
Zfish  1583 SISRYWFYLYDNAACKEIIPTGEFINSKLTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPF 1647

  Fly   628 DYKQKYEYFKSHIR-------------------KPTNVPNKFEIR---IRRTSILEDSYRIISSV 670
            |.:|...|..:..|                   :.:.|..:.:.:   |.|..:|:.:..::..:
Zfish  1648 DTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTINRDELLKQAESVMQDL 1712

  Fly   671 TKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLF--EYSAMDNYTLQINNGS-- 731
            ..:   :..|.:::|.|.|...|. .:|::.|:|:|:.....||:  |...:.|..:....|:
Zfish  1713 GSS---RAMLEIQYENEVGTGLGP-TQEFYALVSQELQRADLGLWRGEEVTLSNPKVGSQEGTKY 1773

  Fly   732 -----GL--------CNEEHLS----YFKFIGRIAGMAVYHGKLLDAFFIRPFYKMML--QKPID 777
                 ||        ....|::    .|:|:|::...|:...:|||.....||||.||  :..|.
Zfish  1774 MFSSRGLFAVPFGRTTKPAHIAKIKMKFRFLGKLMAKAIMDFRLLDLPLGLPFYKWMLRHESSIS 1838

  Fly   778 LKDMESVDTEYYNSLMWIKE---NDPRI-----------------LELTFCLDEDV--------F 814
            ..|:.::|.....|:..:::   ...||                 |.:..|..||:        |
Zfish  1839 SHDLVNIDPGVAKSIQHLEDIIRQKKRIEQDRSHTRETLQQALESLNMNGCSVEDLGLDFTLPGF 1903

  Fly   815 GQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHE 879
               ...|||.||.::.||..|.::|::||:.|.....|..|..||.:||.|:.||:.::.|...|
Zfish  1904 ---PNIELKKGGKDVPVTIHNLEDYLRLVVYWTLNEGVLRQFESFREGFESVFPLHHLQYFYPEE 1965

  Fly   880 LELLMCGIQNIDVKDWRENTLY---KGDYHMNH--IIIQWFWRAVLSFSNEMRSRLLQFVTGTSR 939
            |:.|:||.::   :.|...||.   :.|:...|  ..:::.:..:.||..|.:...||||||:.|
Zfish  1966 LDQLLCGSKS---ESWDVKTLMECCRPDHGYTHDSRAVRFLFEVLSSFDAEQQRLFLQFVTGSPR 2027

  Fly   940 VPMNGFKELYGSNGPQMF---TIEKWGTPNNF-PRAHTCFNRLDLPPYEGYLQLKDK-LIKAIEG 999
            :|:.||:.|   |.|...   |.|....|::| |...||.|.|.||.|.....:::| ||.|.||
Zfish  2028 LPVGGFRSL---NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREG 2089

  Fly  1000 SQGF 1003
            .|.|
Zfish  2090 QQSF 2093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	9/48 (19%)
		WW	581..613	CDD:197736	14/66 (21%)
		HECTc	650..1003	CDD:238033	111/416 (27%)
		HECTc	674..1003	CDD:214523	108/389 (28%)
trip12	XP_005159283.1	WWE	842..907	CDD:280915
		HECTc	1693..2094	CDD:238033	112/414 (27%)
		HECTc	1711..2090	CDD:214523	106/391 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900