DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and LOC564220

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_017212193.1	Gene:	LOC564220 / 564220	-ID:	-	Length:	1406	Species:	Danio rerio

Alignment Length:	231	Identity:	62/231 - (26%)
Similarity:	89/231 - (38%)	Gaps:	60/231 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   459 NRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNP---SDISAP----STRRNSEEDNAA 516
            :::|.:.|.        |...|::...|....|..||..|   .|...|    .....:||...|
Zfish   203 DQVLFEEDF--------GPEVQRKRTTSVSKMDRKDSVVPEEEEDEERPQLPNGIPERTEEWRKA 259

  Fly   517 VPPMEQNTGG------------------EEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNG 563
            ||...|::|.                  ..||||..|.|.....|..:||||.::.|||:|||..
Zfish   260 VPSYTQSSGAGGSGTLEIRTWSSLPRDDSLEPLPYNWEMAYTETGMVYFIDHNTKSTTWLDPRLV 324

  Fly   564 RASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDP----------------- 611
            :.:..|   .:.||  |.||.||||........:|:||..:.||:|:|
Zfish   325 KKAKPP---EKCED--GELPYGWEEIDDPQYGTYYVDHINQRTQFENPVVEAKRKLGLDTAVATQ 384

  Fly   612 ---RLSNPNIAGQAVP-YSRDYKQ-KYEYFKSHIRK 642
               |.:.|.......| ::||..| |.|.:.:.:||
Zfish   385 TQQRAAPPPGGAAGTPGFTRDPTQLKGELYHTALRK 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	12/28 (43%)
		WW	581..613	CDD:197736	13/51 (25%)
		HECTc	650..1003	CDD:238033
		HECTc	674..1003	CDD:214523
LOC564220	XP_017212193.1	PDZ_signaling	15..98	CDD:238492
		NK	120..>198	CDD:327404
		WW	291..323	CDD:197736	15/31 (48%)
		WW	338..367	CDD:306827	12/28 (43%)
		PDZ	412..498	CDD:214570	3/9 (33%)
		PDZ	589..664	CDD:214570
		PDZ_signaling	733..817	CDD:238492
		PDZ_signaling	857..946	CDD:238492
		PDZ_signaling	1011..1084	CDD:238492
		Neuromodulin_N	<1182..>1365	CDD:331332
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910