DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nedd4 and hecw1b

DIOPT Version :9

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:XP_021336549.1 Gene:hecw1b / 563730 ZFINID:ZDB-GENE-060503-2 Length:1555 Species:Danio rerio


Alignment Length:1421 Identity:354/1421 - (24%)
Similarity:523/1421 - (36%) Gaps:506/1421 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 VAGGDVPRPPPRRRAASVAGQQQTRQEFGNGYTPRRSLAAVNDSGDSCHLRIVVLTGQSLAKKDI 87
            ||..|||:...|||..|.                  ||:....:|               .||.:
Zfish   198 VATDDVPQSQGRRRLISF------------------SLSDFQATG---------------LKKGM 229

  Fly    88 FGASDPYVRIDLNTINGDINIDSVLT---KTKK-----KTLNPTW-NEEFIFRVKPSEHKLVFQV 143
            |...|||::|.::.  |..:|...|.   :.|:     .|:||.| .|.|.|...|::   |.::
Zfish   230 FFNPDPYLKIAIHP--GKHSIFPALPHHGQEKRSGIVCNTINPVWQRERFNFVSLPTD---VLEI 289

  Fly   144 -----FDENRLTRDDFLGMVELTLVNLPTEQEGRTIGEQ--SYTLRPRRSVGAKSRIKGTLRIYH 201
                 |.::|.....|||.:.:.:..|   .|...||::  ||||..|...   ..:.|.|:...
Zfish   290 EVKDKFAKSRPIIKRFLGKLSMPVQRL---LEKHAIGDRVVSYTLGRRLPT---EHVSGQLQFRF 348

  Fly   202 AF------------------IRETREQSEPSSGNS------------DGEWEHVE---------- 226
            ..                  :.....|::|.:.::            ||:...||          
Zfish   349 EITSSIHPDDEDMSLSTEQPVAAAEAQAQPQAEDTMSLDLGAPELPLDGDTASVEMPMDVESGQS 413

  Fly   227 --------------------------------ATNAGETSAQPHPFPTGGHDALPAGWEERQDAN 259
                                            .|||.||:....|.         .|.||.:..|
Zfish   414 CAAEADVIEEECLEEEQQEGEAAAAAAAMEQSETNAEETTQVLDPI---------NGAEEEEAEN 469

  Fly   260 GRTYYVNHT-ARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFH-----------ISVDDTES--- 309
            ...:....: ||..:.|........:|:..|..|..|...|..           :.|.:.|:   
Zfish   470 NCAFAEESSDARAGEEDEAISDPQPASEEPDADLEEDCSLRIRTTPRRKPRPCSLPVSELETVIA 534

  Fly   310 ---GRSADSISHNSIEDNNNAAGLAYT-PKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPT 370
               |......|| .|..::....|..| |:|..::...|:.|..       :..:...||::..|
Zfish   535 SACGEPETPRSH-YIRIHHLLHSLPATQPQTGDSAGPEPDRPMG-------VEEEDEEEEEEGVT 591

  Fly   371 VDHTSFVYNSLRHPV----AHRQPEISATSLQNDLRPV--------REAPGVPDIAITNPFTRRA 423
            ::..:...|..|..:    :|.:.......|..|..|:        :.:|.:..:|..:..:.||
Zfish   592 LEDHALTPNGPRRTLPRSRSHERLSDLIQMLDGDGHPLGAEGQTGNQRSPDLSPVACCSHMSPRA 656

  Fly   424 AGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQHR----GQRHQQQHR 484
            :|.:.  |......||.:..:...|..: .:.:|.|.||......:|..|.|    |....::..
Zfish   657 SGPIR--AQSLDSARRSESTVFSSQDDE-DEMEQPNGILGSETETEQGAQCREPGDGSCQWEEAP 718

  Fly   485 PSNEDTDHTDSHNPSDISAPSTRRN--------SEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAP 541
            .|:..:.|....| .:::.||.||.        :.....|:.|...:....:|||||.|..::..
Zfish   719 DSHVQSPHGIVGN-GEVAGPSGRRECPLPCNHPAVSQLPALRPDPHHYPTIDEPLPPNWEARIDS 782

  Fly   542 NGRTFFIDHASRRTTWI--------------------------------------------DPRN 562
            :||.|::||.:|.|||.                                            .|||
Zfish   783 HGRVFYVDHINRTTTWQRPTSAATPDGLRRSGSVQQMEQLNRRYQTIQRTMATERREEESGSPRN 847

  Fly   563 GRA------SPMPNQTRRVEDDLGP---------------------------------------- 581
            .|.      ||:.....|.:....|                                        
Zfish   848 DRTANTETDSPLQTNELRRDTSCSPGHCQKITLLLQSPAVKFITHPEFFTVLHANYGAYRMFTNS 912

  Fly   582 ---------------------------------------LPEGWEERVHTDGRVFYIDHNTRTTQ 607
                                                   ||.|||.:....|:.|::|||:|.|.
Zfish   913 SCLKHMVLKIRRDARNFERYQHNRDLVTFLNRFADAQLELPRGWEIKTDPQGKSFFVDHNSRATT 977

  Fly   608 WEDPR------------------------------------------------------------ 612
            :.|||                                                            
Zfish   978 FIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRTRGVSLLARPGNSLVAAIRNQSQQEP 1042

  Fly   613 ------------LSNPNI----------------------------------------------- 618
                        |..|||                                               
Zfish  1043 VPLAYNDKIVAFLRQPNIFEVLQERQPSFARNHSLKDKVHHIRTEGTQRLEKLSCDADLVMLLSL 1107

  Fly   619 ------------------------------------------------AGQA----------VPY 625
                                                            :|::          .||
Zfish  1108 FEEDIMSYVPLASFHPGFNFSPRCSPGSSPQNSPGFLERTPLVPACCLSGESSPGTQRARAPAPY 1172

  Fly   626 SRDYKQKYE--YFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGET 688
            .||::.|..  |.|...:.....|.|.::.:||..:||.::..:.:.::.:|.:.||::.|.||.
Zfish  1173 RRDFEAKLRNFYRKLEAKGYGQGPGKIKLIVRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEE 1237

  Fly   689 GLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAV 753
            ||||.|.:||:|:|||:|:||||||||||||.|.||:||:..|... |.||.:|:|.|||.|:|:
Zfish  1238 GLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLAL 1301

  Fly   754 YHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEND-PRILELTFCLDEDVFGQK 817
            .|..||||||.|||||.:|:.|.||.|:|.:|.|::.||.|:|||| ..:|:|||.::|:||||.
Zfish  1302 IHQYLLDAFFTRPFYKALLRLPTDLSDLEYLDEEFHQSLQWMKENDITDVLDLTFTVNEEVFGQV 1366

  Fly   818 SQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELEL 882
            ::.|||.||.|:.||.:||.|||:.:::||....|.:|..:.:.||..::...|:.:||..||||
Zfish  1367 TERELKSGGTNVQVTEKNKKEYIERMVKWRVERGVVQQTQALVRGFYEVVDSRLVSVFDARELEL 1431

  Fly   883 LMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKE 947
            ::.|...||:.|||.||.|:|.||..||:|:|||.||..|:||.|.||||||||||.||..||..
Zfish  1432 VIAGTAEIDLNDWRNNTEYRGGYHDGHIVIRWFWGAVERFNNEQRLRLLQFVTGTSSVPYEGFTA 1496

  Fly   948 LYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            |.||||.:.|.|||||...:.|||||||||||||||..|..|.:||:.|:|.:..|
Zfish  1497 LRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYTMLYEKLLIAVEETSTF 1552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 36/166 (22%)
WW 248..277 CDD:278809 7/29 (24%)
WW 531..560 CDD:278809 13/72 (18%)
WW 581..613 CDD:197736 16/182 (9%)
HECTc 650..1003 CDD:238033 182/353 (52%)
HECTc 674..1003 CDD:214523 178/329 (54%)
hecw1bXP_021336549.1 HECW_N 73..192 CDD:318711
C2_NEDL1-like 213..349 CDD:176073 40/179 (22%)
WW 771..803 CDD:197736 14/31 (45%)
WW 952..983 CDD:197736 14/30 (47%)
HECTc 1223..1552 CDD:214523 178/329 (54%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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