DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and hectd2

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_009304826.1	Gene:	hectd2 / 562999	ZFINID:	ZDB-GENE-100405-3	Length:	756	Species:	Danio rerio

Alignment Length:	381	Identity:	123/381 - (32%)
Similarity:	188/381 - (49%)	Gaps:	55/381 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   652 IRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFE 716
            |::||..::.||...:|  .|...||.||.|.|.||.|||.|||.:|||.||.:::|:..||:|.
Zfish   399 IKVRRLQLVSDSLDELS--RKRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHTDYGMFT 461

  Fly   717 YS-----------AMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKM 770
            |.           ..|||                |.|:.:|.:.|:|||:...||..|....||.
Zfish   462 YVKESQCYWFSSWKCDNY----------------SEFRLVGALMGLAVYNSITLDIRFPPCVYKK 510

  Fly   771 MLQKPI--------------DLKDMESVDTEYYNSLMWIKENDPRILE---LTFCLDEDVFGQKS 818
            :|..||              .|.|::.:..:..:.|..:...:..:.|   .||.:.::..|...
Zfish   511 LLTPPIVPCDLDTPVGMATLTLDDLQQIMPDLAHGLGELLSYEGNVEEDFYTTFQVFQEELGVVK 575

  Fly   819 QHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELL 883
            .:.|||||..|.|||.|:.||::|.|::.....:..|.::|..||.|:...|.:.:....|:|:|
Zfish   576 AYNLKPGGDKIPVTNLNRKEYVQLYIDFLLNKSIYRQFAAFYHGFHSVCASNALMLLRPEEVEIL 640

  Fly   884 MCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKEL 948
            :||..|:|:...:....|:| |......|:.||..||:|..|::.:||.|.||:.|||:.|..:|
Zfish   641 VCGSPNLDMGSLQRVVQYEG-YSKTDPTIRAFWDVVLAFPLELQKKLLHFTTGSDRVPVGGMADL 704

  Fly   949 YGSNGPQMFTIEKWGTPNNF-PRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
                   .|.|.|.....:: |.:|||||::.||||:...:|:.||..||..::||
Zfish   705 -------NFKISKIDVSTDWLPVSHTCFNQICLPPYKSKKELRQKLTIAISNAEGF 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736
		HECTc	650..1003	CDD:238033	121/379 (32%)
		HECTc	674..1003	CDD:214523	114/357 (32%)
hectd2	XP_009304826.1	HECTc	397..754	CDD:238033	123/381 (32%)
hectd2	XP_009304826.1	HECTc	420..753	CDD:214523	114/356 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810