DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and nedd4l

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_021324687.1	Gene:	nedd4l / 559634	ZFINID:	ZDB-GENE-051118-2	Length:	1279	Species:	Danio rerio

Alignment Length:	967	Identity:	445/967 - (46%)
Similarity:	563/967 - (58%)	Gaps:	167/967 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 NRLTRDDFLGMVELTLVNLPTEQEGRTIGEQSYT-----LRPRRSVGAKSRIKGTLRIYHAFI-- 204
            |..|||||||.|::.|.:||||....   |:.||     ||||   ..|||:||.||:..|::
Zfish   374 NGQTRDDFLGQVDVPLTHLPTEDPAM---ERPYTFKDFLLRPR---SHKSRVKGYLRLKMAYLPK 432

  Fly   205 -----RETREQSEPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGHDALPAGWEERQDANGRTYY 264
                 .|:.|..|.:.|     ||..::|:.|....|....|      ||.||||:.|..|||||
Zfish   433 NGGHEEESGEMREEAEG-----WEVTDSTDPGSQRPQQLLPP------LPPGWEEKVDNLGRTYY 486

  Fly   265 VNHTARTTQWDRPTVLNSHSSQSTDDQLAS-------DFQRRFHIS------------VDDTESG 310
            |||..|||||.||:.::..|....|:||..       .|:.|.|||            :||:...
Zfish   487 VNHNNRTTQWKRPSSVDVVSETENDNQLRQINQEAHRVFRSRRHISEDLENEQLDIRDIDDSWEP 551

  Fly   311 RS-------ADSISHNSIEDNNNAAGLAYTP----KTAATSSAPPNT----PTNNNGILAQIAMQ 360
            .|       .|.::|:....::.|..|:.||    :.:...|..|:|    |..::.:.:.::.:
Zfish   552 ISEEDPTLLTDGLNHSLSGPSSLAMPLSSTPDFSDEISLRLSLAPDTNGEIPGPSSAVQSHLSSR 616

  Fly   361 YRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPD-------IAITNP 418
            .|:....|...|..              ||.....|.|......:...||.|       .|:|.|
Zfish   617 LRSSSMTDGVSDQA--------------QPPTPTQSSQTRRTRAQTVTGVEDTMSPSASYALTTP 667

  Fly   419 FTRRAAGNMAGG--AGWQQERRRQQMQLHIQQHQQRQ--------QQQQQNRILLDV-------- 465
                       |  .|| :||:..:.:.:...|..|.        ||..::.....|
Zfish   668 -----------GLPPGW-EERKDPKGRTYYVNHNNRSTTWTRPILQQHTEDGASTSVAAVGGATA 720

  Fly   466 -----------DHRQQEPQHR-----------------GQRHQQQHRPSNEDTDHTDSHNPSDIS 502
                       .....|||.|                 |..:....|...:...:..|..||..|
Zfish   721 ATPPASTPSTSSGHLSEPQVRRPRSLSSPTVTLSSPLEGANNVPIRRAVKDTFSNPQSPQPSPYS 785

  Fly   503 APSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASP 567
            :|.|:..:.:..                |||.|.|::|||||.|||||.||.|||.|||  ...|
Zfish   786 SPKTQHKANQSF----------------LPPGWEMRIAPNGRPFFIDHNSRTTTWEDPR--LKYP 832

  Fly   568 MPNQTRRVED--DLGPLPE-----GWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVPY 625
            :..:|:...|  ||||||.     |||||||.|||.||||||.:.||||||||.:|.|.|.||||
Zfish   833 VHMRTKASLDPGDLGPLPNLPEEPGWEERVHADGRTFYIDHNNKKTQWEDPRLQSPAITGPAVPY 897

  Fly   626 SRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGL 690
            ||::||||:||:..::||.::||:||:::.|.:|.|:|||.|.|:.:.|.||.:||:|||.|.||
Zfish   898 SREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSLKRPDSLKARLWIEFESEKGL 962

  Fly   691 DYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYH 755
            ||||:|||||:||||||||||||||||||.||||||||..||||||:||||||||||:|||||||
Zfish   963 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYH 1027

  Fly   756 GKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRILELTFCLDEDVFGQKSQH 820
            |||||.|||||||||||.|.|.|.||||||:||||||.||.||||..|:|.||:|||.|||..|.
Zfish  1028 GKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLRFCIDEDNFGQTYQV 1092

  Fly   821 ELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMC 885
            :|||.|:::.|||:||.|||.|||:||||.||::||::||:||..:||::|||||||:|||||||
Zfish  1093 DLKPSGSDMVVTNDNKKEYIDLVIQWRFVNRVQKQMNAFLEGFTELIPIDLIKIFDENELELLMC 1157

  Fly   886 GIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYG 950
            |:.::||.|||::|:||..|..||.:|||||:|||....|.|.|||||||||||||||||.||||
Zfish  1158 GLGDVDVNDWRQHTVYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYG 1222

  Fly   951 SNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGFAGVD 1007
            |||||:||||:||||:..|||||||||||||.||.:..|::||:.|:|.:|||.|||
Zfish  1223 SNGPQLFTIEQWGTPDKLPRAHTCFNRLDLPMYETFEDLREKLLMAVENAQGFEGVD 1279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	29/61 (48%)
		WW	248..277	CDD:278809	20/28 (71%)
		WW	531..560	CDD:278809	20/28 (71%)
		WW	581..613	CDD:197736	25/36 (69%)
		HECTc	650..1003	CDD:238033	247/352 (70%)
		HECTc	674..1003	CDD:214523	237/328 (72%)
nedd4l	XP_021324687.1	C2	<374..430	CDD:326325	29/61 (48%)
		WW	473..499	CDD:306827	18/25 (72%)
		WW	669..698	CDD:306827	6/29 (21%)
		WW	798..829	CDD:197736	23/32 (72%)
		WW	856..885	CDD:238122	22/28 (79%)
		HECTc	946..1275	CDD:214523	237/328 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	468	1.000	Domainoid score	I439
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86986
Inparanoid	1	1.050	861	1.000	Inparanoid score	I410
OMA	1	1.010	-	-		QHG49869
OrthoDB	1	1.010	-	-		D142537at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm25407
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	1	1.000	-	-		X1682
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010