Protein Alignment Nedd4 and nedd4l

DIOPT Version :10

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: XP_021324693.1
• Gene: nedd4l / 559634
• ZFINID: ZDB-GENE-051118-2
• Length: 1274
• Species: Danio rerio
• Alignment Length: 962
• Identity: 445/962 - (46%)
• Similarity: 563/962 - (58%)
• Gaps: 162/962 - (16%)

  Fly   147 NRLTRDDFLGMVELTLVNLPTEQEGRTIGEQSYT-----LRPRRSVGAKSRIKGTLRIYHAFI-- 204
            |..|||||||.|::.|.:||||....   |:.||     ||||   ..|||:||.||:..|::
Zfish   374 NGQTRDDFLGQVDVPLTHLPTEDPAM---ERPYTFKDFLLRPR---SHKSRVKGYLRLKMAYLPK 432

  Fly   205 -----RETREQSEPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGHDALPAGWEERQDANGRTYY 264
                 .|:.|..|.:.|     ||..::|:.|....|....|      ||.||||:.|..|||||
Zfish   433 NGGHEEESGEMREEAEG-----WEVTDSTDPGSQRPQQLLPP------LPPGWEEKVDNLGRTYY 486

  Fly   265 VNHTARTTQWDRPTVLNSHSSQSTDDQLAS-------DFQRRFHIS------------VDDTESG 310
            |||..|||||.||:.::..|....|:||..       .|:.|.|||            :||:...
Zfish   487 VNHNNRTTQWKRPSSVDVVSETENDNQLRQINQEAHRVFRSRRHISEDLENEQLDIRDIDDSWEP 551

  Fly   311 RS-------ADSISHNSIEDNNNAAGLAYTP----KTAATSSAPPNT----PTNNNGILAQIAMQ 360
            .|       .|.::|:....::.|..|:.||    :.:...|..|:|    |..::.:.:.::.:
Zfish   552 ISEEDPTLLTDGLNHSLSGPSSLAMPLSSTPDFSDEISLRLSLAPDTNGEIPGPSSAVQSHLSSR 616

  Fly   361 YRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPD-------IAITNP 418
            .|:....|...|..              ||.....|.|......:...||.|       .|:|.|
Zfish   617 LRSSSMTDGVSDQA--------------QPPTPTQSSQTRRTRAQTVTGVEDTMSPSASYALTTP 667

  Fly   419 FTRRAAGNMAGG--AGWQQERRRQQMQLHIQQHQQRQ--------QQQQQNRILLDV-------- 465
                       |  .|| :||:..:.:.:...|..|.        ||..::.....|
Zfish   668 -----------GLPPGW-EERKDPKGRTYYVNHNNRSTTWTRPILQQHTEDGASTSVAAVGGATA 720

  Fly   466 -----------DHRQQEPQHR-----------------GQRHQQQHRPSNEDTDHTDSHNPSDIS 502
                       .....|||.|                 |..:....|...:...:..|..||..|
Zfish   721 ATPPASTPSTSSGHLSEPQVRRPRSLSSPTVTLSSPLEGANNVPIRRAVKDTFSNPQSPQPSPYS 785

  Fly   503 APSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASP 567
            :|.|:..:.:..                |||.|.|::|||||.|||||.||.|||.|||  ...|
Zfish   786 SPKTQHKANQSF----------------LPPGWEMRIAPNGRPFFIDHNSRTTTWEDPR--LKYP 832

  Fly   568 MPNQTRRVED--DLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVPYSRDYK 630
            :..:|:...|  ||||||.|||||||.|||.||||||.:.||||||||.:|.|.|.||||||::|
Zfish   833 VHMRTKASLDPGDLGPLPPGWEERVHADGRTFYIDHNNKKTQWEDPRLQSPAITGPAVPYSREFK 897

  Fly   631 QKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGL 695
            |||:||:..::||.::||:||:::.|.:|.|:|||.|.|:.:.|.||.:||:|||.|.||||||:
Zfish   898 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSLKRPDSLKARLWIEFESEKGLDYGGV 962

  Fly   696 AREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLD 760
            |||||:||||||||||||||||||.||||||||..||||||:||||||||||:||||||||||||
Zfish   963 AREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLD 1027

  Fly   761 AFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRILELTFCLDEDVFGQKSQHELKPG 825
            .|||||||||||.|.|.|.||||||:||||||.||.||||..|:|.||:|||.|||..|.:|||.
Zfish  1028 GFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLRFCIDEDNFGQTYQVDLKPS 1092

  Fly   826 GANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNI 890
            |:::.|||:||.|||.|||:||||.||::||::||:||..:||::|||||||:||||||||:.::
Zfish  1093 GSDMVVTNDNKKEYIDLVIQWRFVNRVQKQMNAFLEGFTELIPIDLIKIFDENELELLMCGLGDV 1157

  Fly   891 DVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQ 955
            ||.|||::|:||..|..||.:|||||:|||....|.|.|||||||||||||||||.|||||||||
Zfish  1158 DVNDWRQHTVYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQ 1222

  Fly   956 MFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGFAGVD 1007
            :||||:||||:..|||||||||||||.||.:..|::||:.|:|.:|||.|||
Zfish  1223 LFTIEQWGTPDKLPRAHTCFNRLDLPMYETFEDLREKLLMAVENAQGFEGVD 1274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	29/61 (48%)
		WW	248..277	CDD:459800	20/28 (71%)
		HUL4	<523..1003	CDD:227354	322/481 (67%)
nedd4l	XP_021324693.1	C2	<374..430	CDD:472691	29/61 (48%)
		WW	473..499	CDD:459800	18/25 (72%)
		WW	669..698	CDD:459800	6/29 (21%)
		WW	798..829	CDD:197736	23/32 (72%)
		WW	848..880	CDD:197736	25/31 (81%)
		HECTc	941..1270	CDD:214523	237/328 (72%)