DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and ube3b

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_001108154.1	Gene:	ube3b / 556864	ZFINID:	ZDB-GENE-060526-231	Length:	1069	Species:	Danio rerio

Alignment Length:	431	Identity:	137/431 - (31%)
Similarity:	213/431 - (49%)	Gaps:	55/431 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   621 QAVPYSRDYKQKYEYFKSHIRKPTNV----------PNKFEIRIRRTSILEDSYRIISSVTKTDL 675
            |.:|:...:|.:...|::.:.|....          |:...|.|||:.:|||.|..:..: ..:.
Zfish   643 QYIPHVIPHKNRVLLFRNIVTKEKETLGLVETSSASPHVTHITIRRSRMLEDGYDQLRRL-PVNS 706

  Fly   676 LKTKLWVEFEG-----ETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCN 735
            :|..:.|:|..     |.|:|..|:.:|:...:.|::|||...||: :...|..|..:..|.: :
Zfish   707 IKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKKVFNPALNLFK-TTSGNERLYPSPTSSI-H 769

  Fly   736 EEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPI---------DLKDMESVDTEYYNS 791
            |.||..|:|:|::.|.|:|.|.::|.    ||....|.:.:         .:.::.|:|:|:|.:
Zfish   770 ENHLQLFEFVGKMLGKAMYEGIVVDV----PFASFFLSQVLGHHHSTFYSSIDELPSLDSEFYKN 830

  Fly   792 LMWIKENDPRI--LELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKE 854
            |..||..|..:  |.||...||:|.||...|||.|||..:.||||||..||.|:..:|...::||
Zfish   831 LTSIKRYDGDVSDLGLTLSYDEEVMGQLVCHELIPGGKTMPVTNENKISYIHLMAHFRMHTQIKE 895

  Fly   855 QMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQ-NIDVKDWRENTLYKGDYHMNHIIIQWFWRA 918
            |.::|:.||.|||....:.:|...|::.|:.|.. .||:.|.:::|:|.|.:|.:|.:|.|.|..
Zfish   896 QTAAFIRGFRSIINPEWLHMFSTPEVQRLISGDNAEIDLDDLKKHTVYYGGFHSSHRVILWLWDI 960

  Fly   919 VLS-FSNEMRSRLLQFVTGTSRVPMNGFKEL--------------------YGSNGPQMFTIEKW 962
            :.| |:.:.|:..|:|||..||.|:.||..|                    .||.....|||.|.
Zfish   961 LSSDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKK 1025

  Fly   963 GTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            ......|.:.||||.|.||.|.....|:|||..||..:.||
Zfish  1026 EPGGRLPTSSTCFNLLKLPNYSKKSILRDKLRYAISMNTGF 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736
		HECTc	650..1003	CDD:238033	129/390 (33%)
		HECTc	674..1003	CDD:214523	121/366 (33%)
ube3b	NP_001108154.1	IQ	28..50	CDD:197470
		HECTc	683..1067	CDD:238033	131/391 (34%)
		HECTc	708..1066	CDD:214523	121/363 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810