DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and HERC6

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_005263140.1	Gene:	HERC6 / 55008	HGNCID:	26072	Length:	1034	Species:	Homo sapiens

Alignment Length:	385	Identity:	99/385 - (25%)
Similarity:	179/385 - (46%)	Gaps:	30/385 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   631 QKYEYFKSH---IRKPTNVP--NKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGL 690
            :|..|...|   ::|....|  .:|.:|:||:.:::|:.|.:|....||..|. |.|||..|...
Human   660 EKKAYMLMHETILQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKV-LVVEFINEICP 723

  Fly   691 DYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLC-------NEEHLSYFKFIGRI 748
            :.||::.|:|:.:.:||..|.||:|.|..|           |.|       ..|...||.| |.:
Human   724 ESGGVSSEFFHCMFEEMTKPEYGMFMYPEM-----------GSCMWFPAKPKPEKKRYFLF-GML 776

  Fly   749 AGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRILELTFCLDEDV 813
            .|:::::..:.:..|....||.:|.:...|:|::.:......||..:.::....:....|:...:
Human   777 CGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSI 841

  Fly   814 FGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEH 878
            ...::..:|.|.|.:|.|...||.:|:...|::.|...||.....|..||..:....:::.|...
Human   842 HWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPE 906

  Fly   879 ELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMN 943
            ||...:.|..:.|.|.:.:|:.|:..|..:|..||.||:|....:.:.:.:.|.|:||..|:...
Human   907 ELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHAR 971

  Fly   944 GFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            |.:::     ..:|...:..:..:.|.:.||.|.|.||.|....::::.|..||..::||
Human   972 GIQKM-----EIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736
		HECTc	650..1003	CDD:238033	92/359 (26%)
		HECTc	674..1003	CDD:214523	84/335 (25%)
HERC6	XP_005263140.1	RCC1_2	27..54	CDD:290274
		RCC1_2	89..118	CDD:290274
		RCC1	105..155	CDD:278826
		RCC1	158..208	CDD:278826
		RCC1	215..263	CDD:278826
		RCC1_2	250..279	CDD:290274
		RCC1	266..313	CDD:278826
		HECTc	684..1026	CDD:238033	92/359 (26%)
		HECTc	711..1026	CDD:214523	83/332 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810