DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and Magix

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_061302.2	Gene:	Magix / 54634	MGIID:	1859644	Length:	324	Species:	Mus musculus

Alignment Length:	304	Identity:	63/304 - (20%)
Similarity:	98/304 - (32%)	Gaps:	82/304 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 RSVGAKSRIKGT---------------LRIYHAFIRETREQSEPSSGNSDGEW-EHVEATNAGET 233
            |..||..|::.|               .|:.||.:.:.|.|.:.|  .:.|.| |.:..|....:
Mouse    53 RKAGATLRLRHTEGVSGLDSADIEVTDSRLPHATLVKHRPQHQRS--ETLGTWTEPLPVTQNKAS 115

  Fly   234 SAQPHPFPTGGHDAL----PAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLAS 294
            .|...|..||.....    |||:       |.|.   ...|....|.|..::.         |..
Mouse   116 YALKVPQATGRFSVELTRGPAGF-------GLTL---SGGRNVSGDAPLTVHG---------LLK 161

  Fly   295 D--FQRRFHISVDDTE---SGRSADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGIL 354
            |  .||...:...|..   :|:|...::|..:.:.....|    |........|.:.   :...:
Mouse   162 DGPAQRCGRLQAGDLVLYINGQSTQGLTHAQVVERIRTGG----PHLCLVLQRPQDM---DGSRI 219

  Fly   355 AQIAMQYRAEEDQDP---TVDHTSFVYNSLRHPVAHR-------QPEISATSLQNDLRPV----- 404
            .::....:.:...||   .|:..|.:     .||.||       :|...|.::.:.:|.|
Mouse   220 KEVGGHRKTDRSLDPRGSRVESRSTI-----SPVHHRPKTRTSPRPSPEAVAIGHVVRAVEHPTE 279

  Fly   405 ---REAPGVPD--IAITNPFTRRAAGNMAGGAGWQQE----RRR 439
               ...||.|.  :..:.....||.|...|||....|    |||
Mouse   280 DLENRIPGTPGPWLVPSEDRLSRALGVRGGGAQLALEMAAGRRR 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	8/33 (24%)
		WW	248..277	CDD:278809	7/32 (22%)
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736
		HECTc	650..1003	CDD:238033
		HECTc	674..1003	CDD:214523
Magix	NP_061302.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		PDZ	126..211	CDD:214570	18/107 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..263		9/51 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900