DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and UBR5

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_056986.2	Gene:	UBR5 / 51366	HGNCID:	16806	Length:	2799	Species:	Homo sapiens

Alignment Length:	1202	Identity:	246/1202 - (20%)
Similarity:	400/1202 - (33%)	Gaps:	350/1202 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AALPVPSSSS----SVAGGDVPRPPPRRRAASVAGQQQTRQEFGNGYTPRRSLAAVNDSGDSCHL 72
            ||...|||:|    |.||.....|...||:.:::            .:...:.||:..|..|.:|
Human  1726 AASTAPSSTSTPAASSAGLIYIDPSNLRRSGTIS------------TSAAAAAAALEASNASSYL 1778

  Fly    73 RIVVLTGQSLAK---------KDIFGASDPYVRIDLNTINGDINI---DSV-LTKTKKKTLNPTW 124
                .:..|||:         .|:.|....|..:..:.|...:.:   |:| |....::.|.|||
Human  1779 ----TSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTW 1839

  Fly   125 NEEFIFRVKPS--------------------EHKLVFQVFDENRLTRDDFLGMVELTLVNLPTEQ 169
            |  ::..:..|                    .|.|   ...:|...|:......|.:|..|...:
Human  1840 N--WMVSIMDSTEAQLRYGSALASAGDPGHPNHPL---HASQNSARRERMTAREEASLRTLEGRR 1899

  Fly   170 EGRTIGEQ-----------SYTLRPRRS----------VGAKSRIKGTLRIYHAFI--------- 204
            ....:..:           :|.|...||          |.....:|....::.|.|
Human  1900 RATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQ 1964

  Fly   205 ----------RETREQSEPSSGNSDGEWEHVEATNAGET------------SAQPHPF------- 240
                      :.|||..|....|.|.|.|:.:.||...|            :.|.|||
Human  1965 TTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSM 2029

  Fly   241 -------------PTGGHDALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHS-------- 284
                         |..  :|:|..                       |:|.:|..::
Human  2030 TFLGCIPPNPFEVPLA--EAIPLA-----------------------DQPHLLQPNARKEDLFGR 2069

  Fly   285 -SQSTDDQLASDFQRRFHISVD-------DTESGRSADSISHNSIEDNNNAAGLAYTPKTAATSS 341
             ||......||..:....::||       .|:...:|:..:..::::.....|.........|.|
Human  2070 PSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETES 2134

  Fly   342 APPNTPTNN------NGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEIS--ATSLQ 398
            :.|....::      :.:||:|.:    .|.:.|.:  |||            :|:.|  ...:.
Human  2135 SKPGPSAHDLAAQLKSSLLAEIGL----TESEGPPL--TSF------------RPQCSFMGMVIS 2181

  Fly   399 NDL-------------RPVREAPGV-PDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQ-LHIQQ 448
            :|:             |...|..|. |...:|.          .||...::.:.|::|: |..||
Human  2182 HDMLLGRWRLSLELFGRVFMEDVGAEPGSILTE----------LGGFEVKESKFRREMEKLRNQQ 2236

  Fly   449 HQQRQQQQQQNRILLDVDHRQQEPQHRGQR----HQQQHRPSNEDTDHTDSHNPSDISAPSTRRN 509
            .:....:..::|.||.....:|...|.|:|    ....||......|.....:....|..:....
Human  2237 SRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQ 2301

  Fly   510 SEEDNAAVPPME-----------------QNTGGEEEPLPPRWSMQVAPN---GRTFFIDHASRR 554
            :...|..:|.:|                 :|.|..:........|:.:..   |.....|...||
Human  2302 AFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRR 2366

  Fly   555 TTWIDPRNGRASPMPNQTRRVEDDLGPLP---EGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNP 616
            ...||.|..|.:...|.:    ||..|||   :...||::.  ||          |...|..::
Human  2367 QLSIDTRPFRPASEGNPS----DDPEPLPAHRQALGERLYP--RV----------QAMQPAFAS- 2414

  Fly   617 NIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRR------TSILE----DSYRIIS--- 668
            .|.|..:..|.  .|......|.......|....|:.|..      .|||:    ||...:.
Human  2415 KITGMLLELSP--AQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQEN 2477

  Fly   669 --------SVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTL 725
                    ||...||..|        :.|.|...|    ||...|..|              ||.
Human  2478 RKRHGSSRSVVDMDLDDT--------DDGDDNAPL----FYQPGKRGF--------------YTP 2516

  Fly   726 QINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYN 790
            :    .|...|..|:.|:.||||.|:.:...:|......|...|::|.:.::..|....|...|.
Human  2517 R----PGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYE 2577

  Fly   791 SLMWI----KENDP----RILELTFCLD---EDVFGQKSQHELKPGGANIDVTNENKDEYIKLVI 844
            ||..:    :.:|.    ..::|.|.:|   |:..||.   ||.|.|.||.||.:|..||::...
Human  2578 SLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVNIPVTPQNVYEYVRKYA 2639

  Fly   845 EWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMN- 908
            |.|.:...::.:.:...|...::|.|.::.....:..||:.|...::|:.....|.:..:...|
Human  2640 EHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENA 2704

  Fly   909 HIIIQ---WFWRAVLSFSNEMRSRLLQFVTGTSRVPMN--GFKELYGSNGPQMFTIEKWGTPN-- 966
            ..::|   |||..|...|...|..|:.|.|.:..:|.:  ||:.:     |.: ||.   .|:
Human  2705 EKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPM-----PSI-TIR---PPDDQ 2760

  Fly   967 NFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIE 998
            :.|.|:||.:||.:|.|.....||.||:.||:
Human  2761 HLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	31/186 (17%)
		WW	248..277	CDD:278809	2/28 (7%)
		WW	531..560	CDD:278809	6/31 (19%)
		WW	581..613	CDD:197736	9/34 (26%)
		HECTc	650..1003	CDD:238033	99/389 (25%)
		HECTc	674..1003	CDD:214523	90/344 (26%)
UBR5	NP_056986.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..175
		CUE_UBR5	184..230	CDD:270606
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..352
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	999..1031
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1052..1075
		ZnF_UBR1	1177..1244	CDD:197698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1299..1318
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1515..1740		6/13 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1859..1890		4/33 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1984..2021		8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2117..2142		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2323..2392		16/72 (22%)
		PolyA	2389..2452	CDD:197769	17/77 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2473..2493		3/19 (16%)
		HECTc	2501..2796	CDD:214523	85/326 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900