Protein Alignment Nedd4 and nedd4l

DIOPT Version :10

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: XP_012815048.1
• Gene: nedd4l / 448382
• XenbaseID: XB-GENE-489248
• Length: 1290
• Species: Xenopus tropicalis
• Alignment Length: 1189
• Identity: 476/1189 - (40%)
• Similarity: 626/1189 - (52%)
• Gaps: 264/1189 - (22%)

  Fly     6 SGLVAAAA-----LPVPSSSSSVAGGDVPRPP--PRRRAASVAGQQQTRQEFGNGYTPRR-SLAA 62
            :|.:..||     :.:.:|..:.:|..:.|.|  |..|...:....|..|. |:...||| ||..
 Frog   179 NGHINCAADMQEEVSITTSGQNTSGIRIKRQPLSPDIRQVRLLSPCQENQN-GSNTEPRRWSLQH 242

  Fly    63 VNDSGDSCHLRIVVL------TGQS-LAKKDIFGASD---------PYVRIDLNTI--------- 102
            :.|:..|...|..|.      ||.| :..:..||.:.         |.:|::.:|.
 Frog   243 LPDTSGSPGKRCFVFQLQQSQTGNSNMGGEYNFGFTGTKGDRLVRYPRIRLERSTSYPLQPRPES 307

  Fly   103 -----NGDINIDSVLTKTKKKTLNPTWNEEFIFRVKPSEHK-LVFQVFDENRL------------ 149
                 ||   :.|...|.||.......|:.   |.:||:.: ..|::..|:.:
 Frog   308 TSPVENG---LSSESGKCKKDYAEILPNDS---RERPSQGQGCTFKIRQESNVRQPHFRIRVTRS 366

  Fly   150 ----------------------TRDDFLGMVELTLVNLPTEQEGRTIGEQSYT-----LRPRRSV 187
                                  |||||||.|::.|.:||||....   |:.||     ||||
 Frog   367 SEEQGTEEGQDVPRNSALGKATTRDDFLGQVDVPLNHLPTEDPTM---ERPYTFKDFLLRPR--- 425

  Fly   188 GAKSRIKGTLRIYHAFI-------RETREQSEPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGH 245
            ..|||:||.||:..|::       .|..||.|    .|:..|:.|::.::.....|..|.|
 Frog   426 SHKSRVKGFLRLKMAYLPKNGMQEEENNEQRE----ESEQAWDVVDSNDSSSPHQQELPAP---- 482

  Fly   246 DALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTD-----DQLASDFQRRFHIS-- 303
             .:|.||||:.|..||||||||..:||||.||::::..|...::     .:....|:.|.|||
 Frog   483 -PMPPGWEEKVDNLGRTYYVNHNNKTTQWQRPSLVDVTSESDSNIRHIQQEAHRVFRSRRHISED 546

  Fly   304 --VDDTESGRSA----DSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGIL-------- 354
              .|..|.|...    ::||..          :..|..|...|..||.:|.:....|
 Frog   547 LEPDHIEGGADVPEPWETISEE----------MTLTTDTLNQSLPPPASPDSRASALELSEELNR 601

  Fly   355 -AQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAH-----------RQPEISATSLQ--------- 398
             .||:.:...|  |..::..|::.....|.|...           .|..:|..|:.
 Frog   602 RLQISSESNGE--QFSSIIQTAWERQKQREPSTRLRSCSVTDGVAEQAHLSLPSVSTGRARSSTV 664

  Fly   399 ---NDLRP----VREAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQ--- 453
               .|..|    |...||:|                   :|| :||:..:.:.:...|..|.
 Frog   665 TGGEDSTPTVAYVHTTPGLP-------------------SGW-EERKDAKGRTYYVNHNNRTTTW 709

  Fly   454 -----QQQQQNRI--LLDVDHRQQEPQHR-----------------GQRHQQQHRPSNEDTDHTD 494
                 |..:...:  ..:..:...|||.|                 |.:.....|...:...:..
 Frog   710 TRPIVQHAEDGAVGSTSNSSNHLSEPQIRRPRSLSSPTVTLSAPLEGAKDFPVRRAVKDTLSNPQ 774

  Fly   495 SHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWID 559
            |..||..::|..:..                |.:..|||.|.|::|||||.|||||.::.|||.|
 Frog   775 SPQPSPYNSPKPQHK----------------GAQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWED 823

  Fly   560 PR-------NGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDH---------------- 601
            ||       ..:||..||       ||||||.|||||:|.|||.|||||
 Frog   824 PRLKFPVHMRTKASLNPN-------DLGPLPPGWEERIHGDGRTFYIDHRSPGLRCRDTGTSCSV 881

  Fly   602 ---NTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDS 663
               :|:.||||||||.||.|.|.||||||::||||:||:..::||.::||:||:::.|.:|.|:|
 Frog   882 PPYDTKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEES 946

  Fly   664 YRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQIN 728
            ||.|.||.:.|:||.:||:|||.|.||||||:|||||:||||||||||||||||||.||||||||
 Frog   947 YRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 1011

  Fly   729 NGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLM 793
            ..||||||:|||||.|||||||:||:||||||.|||||||||||.|.|.||||||||:||||||.
 Frog  1012 PNSGLCNEDHLSYFTFIGRIAGLAVFHGKLLDGFFIRPFYKMMLGKQITLKDMESVDSEYYNSLK 1076

  Fly   794 WIKENDPRILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSS 858
            ||.||||..|:|.||:||:.|||..|.:|||.|:.:.|||:||.|||.|||:||||.||::||::
 Frog  1077 WILENDPTELDLRFCIDEENFGQTYQVDLKPNGSEMVVTNDNKREYIDLVIQWRFVNRVQKQMNA 1141

  Fly   859 FLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFS 923
            ||:||..:||::|||||||:||||||||:.::||.|||::||||..|..||..|||||:|||...
 Frog  1142 FLEGFTELIPIDLIKIFDENELELLMCGLGDVDVNDWRQHTLYKNGYCPNHPAIQWFWKAVLLMD 1206

  Fly   924 NEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQ 988
            .|.|.|||||||||||||||||.|||||||||:||||:||:|:..|||||||||||||||:.:..
 Frog  1207 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPDKLPRAHTCFNRLDLPPYDSFED 1271

  Fly   989 LKDKLIKAIEGSQGFAGVD 1007
            |::||:.|:|.:|||.|||
 Frog  1272 LREKLLMAVENAQGFEGVD 1290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	50/202 (25%)
		WW	248..277	CDD:459800	18/28 (64%)
		HUL4	<523..1003	CDD:227354	321/505 (64%)
nedd4l	XP_012815048.1	C2	<389..442	CDD:472691	28/58 (48%)
		WW	485..513	CDD:459800	18/27 (67%)
		WW	683..712	CDD:459800	7/48 (15%)
		WW	796..826	CDD:238122	19/29 (66%)
		WW	845..896	CDD:197736	24/50 (48%)
		HECTc	957..1286	CDD:214523	235/328 (72%)