Protein Alignment Nedd4 and kibra

DIOPT Version :9

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Alignment Length: 616
• Identity: 143/616 - (23%)
• Similarity: 220/616 - (35%)
• Gaps: 217/616 - (35%)

  Fly   436 ERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSD 500
            ::...|.|.|:..|..|.|||||..    ..|.||:.|.:...||||.:      .|:|.
  Fly     5 QQTASQSQHHLHPHHLRPQQQQQQH----HHHHQQQQQQQHTHHQQQQQ------HHSDF----- 54

  Fly   501 ISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRA 565
                                         |||..|.:....:|:|::|||.:::|||:|||:...
  Fly    55 -----------------------------PLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYT 90

  Fly   566 SPMPNQTRRVEDDLG-PLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVPYSRDY 629
            .|   ||  .||.:| .||.||||....:...:||:|..::||.||||.....:..|.:   .||
  Fly    91 KP---QT--FEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQML---SDY 147

  Fly   630 --------KQKYEYF---KSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTD--LLKTKLW 681
                    :.|.|.|   :..:.......|..::...|:|:...|    ||:::.|  ||:..|.
  Fly   148 LSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSSLCSSS----SSMSRHDPELLRADLM 208

  Fly   682 VEFEGETGLDYGGLAREWFYLLSKEM-------------FNPYYGLFEYSAMDNYTLQINNGSGL 733
                         ||||..:.|.:|:             .|..|.:.|         :||.....
  Fly   209 -------------LARERVHQLKQELTHITNDISYTERGMNTLYSVGE---------KINARENG 251

  Fly   734 CNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIK-- 796
            |.:              :|..|.       ||   :.||:....|...|.|..|...||:.||
  Fly   252 CYD--------------IAEVHA-------IR---EEMLKVHKSLVSGEKVREELMRSLVQIKNE 292

  Fly   797 --------ENDPRILELTFCLDE-------DVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEW 846
                    ||.    :|....|.       |:.|  |..|...|||......:.|.:|    .||
  Fly   293 LGRQQISEENS----DLASPFDRVCVASQTDLCG--SSGENLNGGARFAEMAKTKWQY----AEW 347

  Fly   847 R-FVARVKEQMSSFLDGFGSIIPLNLIKIFDE----HELELLMCGIQNIDVKDWRENTLYKGDYH 906
            | .:.::::|::..::   .|.|..|....|.    .|.|.|:..:.:|.:|...|..
  Fly   348 RKHIKKLQQQLADHVE---RIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEE------- 402

  Fly   907 MNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRA 971
                      :.|:   ::.|.:|.:           ..||.|.:|
  Fly   403 ----------KRVI---HQTRHKLEE-----------DLKEAYEAN------------------- 424

  Fly   972 HTCF-NRLDLPPYEGYLQLKDKLIKAIEGSQ 1001
            :||. |||..  :|....|.|||.:|::.::
  Fly   425 NTCVANRLRF--HEEKQLLLDKLQEALKSTK 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	11/28 (39%)
		WW	581..613	CDD:197736	14/31 (45%)
		HECTc	650..1003	CDD:238033	80/390 (21%)
		HECTc	674..1003	CDD:214523	75/366 (20%)
kibra	NP_001034055.1	WW	57..87	CDD:238122	12/29 (41%)
		WW	103..132	CDD:278809	12/28 (43%)
		C2_Kibra	693..813	CDD:176062

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900