DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nedd4 and ctrip

DIOPT Version :9

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:NP_001189170.1 Gene:ctrip / 40596 FlyBaseID:FBgn0260794 Length:3140 Species:Drosophila melanogaster


Alignment Length:1454 Identity:266/1454 - (18%)
Similarity:429/1454 - (29%) Gaps:599/1454 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSARSSGLVAAAALPVPSSSSSVAGG------DV--PRPPPRRRAASVAGQQQTRQE-------- 49
            :::.|||   ||:....|||||.|..      |:  .:.||:|::.| .|:.::|||        
  Fly  1832 LASTSSG---AASSSSSSSSSSSASALQHKMTDMLKRKAPPKRKSQS-GGRAKSRQEDAAVAPAG 1892

  Fly    50 FGNGYTPRRSLAAVNDSGDSCHLRIVVLT---------------GQSLAKKDIFGASDPYVRIDL 99
            .|.|..|..|      ||.:.|..:...|               |.|.:.|..|.|.        
  Fly  1893 SGPGGAPPSS------SGSAMHELLSRATSLGSGNGGRSTPNSGGGSGSSKSRFNAG-------- 1943

  Fly   100 NTINGDINIDSVLTKTKKKTLNPT-WNEEFIFRVKPSEHKLVFQVFDENRLTRDDFLGMVELTLV 163
            |:.|...:..|.|.     :|||. |..:                                    
  Fly  1944 NSSNAGSSKSSFLA-----SLNPARWGRQ------------------------------------ 1967

  Fly   164 NLPTEQEGRTIGEQSYTLRPRRSVGAKSRIKGTLRIYHAFIRETREQSEPSSGNSDGEWEHVEAT 228
               |.|......:||.                  :.:|...:::...:...||:..|....|...
  Fly  1968 ---THQNHHHHHQQSQ------------------QQHHGLSKDSGNSNSTGSGSGAGLAYTVSQH 2011

  Fly   229 NAGETSAQPHPFPTGGHDALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLA 293
            .||..:.       |.:.|..|....:..::.......:..|..||.|              :.|
  Fly  2012 GAGSGAG-------GLNAAAVAASISKSISHANLLAAANRERARQWVR--------------EQA 2055

  Fly   294 SDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIA 358
            .||.:|:    .:.|:.||..:....:.:..::..||:.|..|..:::...|.....:.||.::.
  Fly  2056 VDFVKRY----TEQEAKRSKAASESGATQSGSSGVGLSSTGNTPLSTAGSTNVLERLSSILFKLN 2116

  Fly   359 MQYR-------------AEEDQDP-TVDHTSFV-----YNSLRHPVAHRQPEI-------SATSL 397
            ..|.             .|.|..| .|:|:..:     |.:....:..|...:       :...|
  Fly  2117 GSYHDCLDALLELKTILLESDISPFEVNHSGLIKAMLNYMTSETGLVERDARLRSFMHVFAGLPL 2181

  Fly   398 QNDLRPVREAPGVPDIAITNPFTRRAAGNMA----------------GGAGWQQERR---RQQMQ 443
            :..|:.|.:.|.:..||. ..|..:..|.:.                ||...|...|   ..|::
  Fly  2182 EPLLQNVGQMPTIEPIAF-GAFVAKLNGCVTQLEQFPVKVHDFPAGPGGRSNQSALRFFNTHQLK 2245

  Fly   444 LHIQQHQQ----RQQQ------------QQQNRILL---------DVDHRQQEP----------Q 473
            .::|:|.|    ||.:            |...|.|:         |.|...:|.          .
  Fly  2246 CNLQRHPQCNNLRQWKGGTVKIDPLAMVQAIERYLVVRGYGGIRADSDDDSEEDMDDNVAAVVLS 2310

  Fly   474 HRGQRHQQQHRPSNEDTDHTDSHN-----------PSDISAPSTRRNSEE--DNAAV-------- 517
            ....||:.|....    ||...:|           |.....|.|...||.  .||::        
  Fly  2311 QASFRHKLQFTIG----DHVLPYNMTVYQAVKQFSPLVSEQPETDNESETLLGNASIWVQQHTIH 2371

  Fly   518 --PPMEQNTGG------------------------------------------------------ 526
              |..|:.|.|                                                      
  Fly  2372 YRPVEEEVTSGAAAGAASSSSSCSSGVQKQQSSSSSASSCVNATSSCSSSSGVASGGGSLTKKAH 2436

  Fly   527 --------EEEPLPPRWSMQVAP---NGRTFFID------------------------HASRRTT 556
                    ::..|   |...:||   :....|:.                        ||..| .
  Fly  2437 KSSSKFMRKKTEL---WHEGIAPVVISALKPFLSSSLPADVVTVQDASLDALCMLRVIHALNR-H 2497

  Fly   557 W-----------IDPRNGRASP--MPNQTRRVEDDL----GPLPEGWEERVHTDGRVFYIDHNTR 604
            |           |.|::....|  |....|:::|.|    |.||                     
  Fly  2498 WDHLYGCVVRQNIIPQSDFIHPKIMAKANRQLQDPLVIMTGNLP--------------------- 2541

  Fly   605 TTQWEDPRLSNPNIAGQAVPYSRDYKQKYEYF--------------------KSHIRKPTNVPNK 649
              ||      .|.| |.|.|:...::.::..|                    .:.......|..:
  Fly  2542 --QW------LPQI-GMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESSERVAPR 2597

  Fly   650 FEIR---IRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPY 711
            .:.|   |.||.||:.:..|:.....:   |..|.:::|.|.|...|. ..|::.|:|.|:....
  Fly  2598 LDRRKRAISRTEILKQAEHILQDFGHS---KALLEIQYENEVGTGLGP-TLEFYALVSAELQRTD 2658

  Fly   712 YGLF------------------------------------------------------------- 715
            .||:                                                             
  Fly  2659 LGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQ 2723

  Fly   716 ------------------------EYS----------------------------AMDN------ 722
                                    |:|                            |:||      
  Fly  2724 HQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTT 2788

  Fly   723 ------YTLQINNGSGLCNEEHLSY---------------------------FKFIGRIAGMAVY 754
                  :....||.|.:......||                           |||:|:....||.
  Fly  2789 ATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFLGKFMAKAVM 2853

  Fly   755 HGKLLDAFFIRPFYKMML--QKPIDLKDMESVDTEYYNSLMWIKE---------NDPRI------ 802
            ..::||..|..|||:.::  :..|.|.|:..|..|..|:|:.:::         :||.|      
  Fly  2854 DSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDAMEKT 2918

  Fly   803 -----LELTFCLDED-----VFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMS 857
                 |:|..|...|     |....:..||..||.:..||..|..:||.||..|..:..|::|..
  Fly  2919 EKIEQLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFE 2983

  Fly   858 SFLDGFGSIIPLNLIKIFDEHELELLMCGI------QNIDVKDWRENTLYKGDYHMNHIIIQWFW 916
            :..:||.|:.|:..:::|...|||.:.||.      ...::|..:|:......:|.:...||:.:
  Fly  2984 ALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQDSQAIQYLY 3048

  Fly   917 RAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNF-PRAHTCFNRLDL 980
            ..:.|::.:.:...||||||:.|:|..|||.|.........|:::...||:: |...||.|.|.|
  Fly  3049 EILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTCVNYLKL 3113

  Fly   981 PPYEGYLQLKDKL-IKAIEGSQGF 1003
            |.|.....::.|| :.|.|||..|
  Fly  3114 PDYSSREVMRQKLKVAANEGSMSF 3137

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 20/148 (14%)
WW 248..277 CDD:278809 4/28 (14%)
WW 531..560 CDD:278809 10/66 (15%)
WW 581..613 CDD:197736 4/31 (13%)
HECTc 650..1003 CDD:238033 115/542 (21%)
HECTc 674..1003 CDD:214523 108/515 (21%)
ctripNP_001189170.1 Extensin_2 <688..731 CDD:252669
WWE 1409..1481 CDD:128922
FAM199X <1985..2074 CDD:292442 20/113 (18%)
HECTc <2818..3138 CDD:294058 87/320 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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