DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and Ube3a

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster

Alignment Length:	468	Identity:	132/468 - (28%)
Similarity:	218/468 - (46%)	Gaps:	69/468 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   581 PLPEGWEE------RVHTDGRVFYIDHNTRTTQWEDPR-------------LSNPNIAGQAVPYS 626
            ||.|.:.|      ::|.|    |:.:.|...:.|...             :..|:....|:.|.
  Fly   527 PLEEFYNEALSENIQMHHD----YLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYD 587

  Fly   627 ---RDYKQKYEYFKS------HIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDL--LKTKL 680
               |.|.::|....|      .:.:..|.....::.:||..::.|:...:..|..::.  ||.:|
  Fly   588 SRMRMYSERYSSLHSILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQL 652

  Fly   681 WVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLF----EYSAMDNYTLQINNGSGLCNEEHLSY 741
            .|||.||.|:|.||:::|:|.|:.:|:|||.:|:|    |.:.|........||         :.
  Fly   653 VVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENG---------AQ 708

  Fly   742 FKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLM----WIKENDPRI 802
            |..||.|.|:|:|:...|...|....|:.::.......|:.......|.||.    :..::...:
  Fly   709 FTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEV 773

  Fly   803 LELTFCLD-EDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSI 866
            .|.||.:. .||||...||||.|.|.::.|...||:.::.|..::.....:::|.::|..||..:
  Fly   774 FEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMV 838

  Fly   867 I---PLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRS 928
            .   ||.|  :|...|:|:|:||.:..|..:...:|:|:|.|......||.||..|.:..:|.:.
  Fly   839 TDESPLKL--LFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKH 901

  Fly   929 RLLQFVTGTSRVPMNGFK---ELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLK 990
            :||:|.||::|||:.|.|   .|...:||.         .:..|.:|||||.|.||.|....:|:
  Fly   902 KLLEFTTGSARVPVGGLKCLRLLITRHGPD---------SDRLPTSHTCFNVLLLPEYSSREKLE 957

  Fly   991 DKLIKAIEGSQGF 1003
            ::|:|||..|:||
  Fly   958 ERLMKAINYSKGF 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736	9/50 (18%)
		HECTc	650..1003	CDD:238033	113/369 (31%)
		HECTc	674..1003	CDD:214523	109/345 (32%)
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	115/371 (31%)
		HECTc	647..970	CDD:214523	109/342 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446968
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740