DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and CG5087

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster

Alignment Length:	432	Identity:	127/432 - (29%)
Similarity:	199/432 - (46%)	Gaps:	62/432 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   623 VPYSRDYKQKYEYFKSHIRKPTNV----------PNKFEIRIRRTSILEDSYRIISSVTKTDLLK 677
            :|:...::.:.:.|:..::....|          |....|.|.|..|:||.||.::: ..|..||
  Fly   655 MPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDGYRQLAA-QPTQALK 718

  Fly   678 TKLWVEF---EG--ETGLDYGGLAREWFYLLSKEMFNPYYGLFE-------YSAMDNYTLQINNG 730
            ..:.|.|   :|  |.|:|..|:.:|:.....|::|:|...||:       |.:..:|.
  Fly   719 GVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQRLYPSPISYV------ 777

  Fly   731 SGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPID-----LKDMESVDTEYYN 790
                .:.||..|:|:||:.|.|||.|.::|..|...|...:|.:...     :.::.|:|.|.|.
  Fly   778 ----QDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYR 838

  Fly   791 SLMWIK--ENDPRILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVK 853
            ||.:||  :.|...|.|||.:|:||.|:.....|.|||....|.:.||..||..:..:....:::
  Fly   839 SLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIR 903

  Fly   854 EQMSSFLDGFGSIIPLNLIKIFDEHELELLMCG-IQNIDVKDWRENTLYKGDYHMNHIIIQWFWR 917
            ||..:|..||.||:....:.:|...||:.|:.| ...:|:||.:::|.|.|.:|..|.::.|.|.
  Fly   904 EQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWD 968

  Fly   918 AVL-SFSNEMRSRLLQFVTGTSRVPMNGFKEL--------------------YGSNGPQMFTIEK 961
            .:. .|:.|.|...|:|||..|:.|:.||..|                    .||.....|.|.|
  Fly   969 ILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRK 1033

  Fly   962 WGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            ....|..|.:.||||.|.||.|:....|:|||..|:..:.||
  Fly  1034 KDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGF 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736
		HECTc	650..1003	CDD:238033	121/393 (31%)
		HECTc	674..1003	CDD:214523	112/369 (30%)
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	123/393 (31%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	111/366 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446998
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740