DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and CG3356

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster

Alignment Length:	849	Identity:	204/849 - (24%)
Similarity:	348/849 - (40%)	Gaps:	180/849 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 EATNAGETSAQPHPFPTGGHDALPAGWEERQDANGRT--YYVNHTART----TQWDRPTVLNSHS 284
            ::|..|..:| ||....|..|:..:..|:.:....||  |.:..|.||    :..:|..:|.|.:
  Fly   380 KSTLRGHANA-PHRHRDGDDDSEESEDEDEELPAARTLDYDMEQTCRTSGELSVKERECLLESIA 443

  Fly   285 SQSTDDQLASDF-QRRFHISVDDTESGRSADSISHNSIEDNNNAA-------GLAYTP------- 334
            ..:..:::  || .::....:::|....:...|.||.:..|.:|.       .||:||
  Fly   444 ILNETERV--DFIVQQLDPHIENTHLIYALCEICHNLMIYNKHAVFEYKLLYTLAFTPKFIRAVW 506

  Fly   335 -KTAATS-----SAP-----PNTPTNNNGI------LAQIAMQYRAEEDQDPTVDHTSFVYNSL- 381
             |.||.|     |||     ......:.|:      ||...|.:..   ..||:....||.|.|
  Fly   507 FKLAAESTQLGFSAPLTLISKGVVPKHQGVDRTIPLLATFCMLFGR---LLPTLHDVEFVENKLL 568

  Fly   382 ---RHPVAH-RQPEISATSLQNDLRPVRE-APGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQ 441
               ...:.| |....|...:....:.::: :.|:.::|.  |.||....|.....|
  Fly   569 LQVHSTINHVRLMPFSIAEIIQMSKTLKDISMGLVELAF--PETRSNLANYRKVLG--------- 622

  Fly   442 MQLHIQQHQQRQQQQQQ------NRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTDH-------T 493
               |.:...::.:.|:|      |.::..::          |.|.:..|......||       .
  Fly   623 ---HTEADDKKLRHQKQIWANLLNVVVFVLN----------QIHTRDLRLGFCPEDHWTVTRLDL 674

  Fly   494 DSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWI 558
            ....|:|:  |.|..:.........|:...|..:.|..||..:.|:    |:..|   .|...::
  Fly   675 PLDRPTDL--PLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQI----RSITI---LREIPFV 730

  Fly   559 DPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAV 623
            .|.|.|.|.:.:           |....:.||..:.:.|               |..|::.
  Fly   731 VPFNKRVSILQS-----------LVAASKMRVQGNMQAF---------------LQGPSVL---- 765

  Fly   624 PYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEG-- 686
                                        |.:||:.:.||:|..:....:.| |:.|..::|..
  Fly   766 ----------------------------ITVRRSHLYEDAYDKLRPDNEPD-LRFKFRIQFVSSL 801

  Fly   687 ---ETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRI 748
               |.|:|.||:.||:...|.|..|:|..|.|..:. ||......|.:.|. |::..::.|||||
  Fly   802 GLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTT-DNKLYPNPNVADLF-EDYEKHYYFIGRI 864

  Fly   749 AGMAVYHGKLLDAFFIRPFYKMMLQK------PIDLKDMESVDTEYYNSLMWIKE--NDPRILEL 805
            .|.::|...|::.    |..:..|.|      .:|:..:.|:|.|.|.:|:::|:  .|...|.|
  Fly   865 LGKSIYENLLVEL----PLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSELNL 925

  Fly   806 TFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLN 870
            .|.:.....||....||||.|.:|.|||.|:.||::|:.:::...:::...::|..|..:::|:.
  Fly   926 DFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIE 990

  Fly   871 LIKIFDEHELELLMCGIQ-NIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFV 934
            .:.:|...||::|:.|.: .||::|.:::..|.|::...|..|..||..:..|.:..|.:||:||
  Fly   991 WLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFV 1055

  Fly   935 TGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEG 999
            |..||.|:.|||:|    .|..| |:..|.....|.|.||.|.|.|||::...|:::||:.||:.
  Fly  1056 TSCSRPPLLGFKDL----DPPFF-IQNTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQS 1115

  Fly  1000 SQGF 1003
            ..||
  Fly  1116 GAGF 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809	7/34 (21%)
		WW	531..560	CDD:278809	6/28 (21%)
		WW	581..613	CDD:197736	4/31 (13%)
		HECTc	650..1003	CDD:238033	114/366 (31%)
		HECTc	674..1003	CDD:214523	108/342 (32%)
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	116/366 (32%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	108/342 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446976
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740