Protein Alignment Nedd4 and Magi

DIOPT Version :9

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: NP_001286661.1
• Gene: Magi / 37403
• FlyBaseID: FBgn0034590
• Length: 1202
• Species: Drosophila melanogaster
• Alignment Length: 552
• Identity: 109/552 - (19%)
• Similarity: 185/552 - (33%)
• Gaps: 172/552 - (31%)

  Fly   201 HAFIRETREQSEPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGHDALPAGWEERQDANGRTYYV 265
            |.:.::..:|..|.:.:...:..|            |||.|
  Fly    53 HFYQQQQPQQLAPLNASHQHQHSH------------PHPHP------------------------ 81

  Fly   266 NHTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGL 330
            :..|..|.:   ...|.:|  :.:..||:...|:|:.|.|              :::|..:|..:
  Fly    82 HPVAAATSF---ATFNGNS--NLNSSLANGSSRKFNCSRD--------------NVDDGGDAGEM 127

  Fly   331 AYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISAT 395
            |...:|  .|||..:...|.:|             ..:.||.........|..|..|.
  Fly   128 AAASQT--LSSAGTDVVGNGSG-------------HGNGTVTGNGEKSGGLAPPGGHH------- 170

  Fly   396 SLQNDLRPVREAPGVPDI------AITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQ 454
                 |||    |..|.:      .|.|..:|....:::|.:.     ...||.:    |.|...
  Fly   171 -----LRP----PPPPALKKSASAVIGNSASREDVASLSGTSS-----LNSQMSV----HNQFIS 217

  Fly   455 QQQQNRILLDVDH------RQQEPQH--RGQRHQ-QQHRPSNEDTDHTDSHNPSDISAPSTRRNS 510
            ....|.|..:..|      |...|..  :|.:.. .|:...|.:|.  ||...|:......:..:
  Fly   218 GLPSNGIGSNGVHGGAATGRGGPPNSILKGSKENLLQNTYYNGETG--DSSLGSECGVGDVQHQN 280

  Fly   511 EEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRV 575
            .|.:       .:.|....||||:|.......|..:||||.:..:.|:|||..:     .|.:.:
  Fly   281 HESH-------DDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSK-----YQKKSL 333

  Fly   576 EDDL-GPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYEYFKSH 639
            ||.. ..||.|||:...:...:::|||..|.||:|:|.|.....|.:.....:..:|:.:..:..
  Fly   334 EDCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQ 398

  Fly   640 IRK------------------------PTNVPNKF-----EIRIRR--TSILEDS----YRIISS 669
            ..|                        |..:|.||     |::.:|  |::|:.|    :.|:.|
  Fly   399 RSKTPTALSETMPTEAAEAHEQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLGFTIVGS 463

  Fly   670 ------------VTKTDLLKTKLWVEFEGETG 689
                        ..||.:.....|::.:.:||
  Fly   464 DGSAGGDVEEFLQIKTVVPNGPAWLDGQLQTG 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	1/2 (50%)
		WW	248..277	CDD:278809	2/28 (7%)
		WW	531..560	CDD:278809	10/28 (36%)
		WW	581..613	CDD:197736	13/31 (42%)
		HECTc	650..1003	CDD:238033	13/63 (21%)
		HECTc	674..1003	CDD:214523	3/16 (19%)
Magi	NP_001286661.1	WW	294..323	CDD:278809	10/28 (36%)
		WW	342..372	CDD:238122	12/29 (41%)
		PDZ	443..534	CDD:214570	11/53 (21%)
		DegQ	<455..534	CDD:223343	7/41 (17%)
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900