DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and Yap1

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_006242550.1	Gene:	Yap1 / 363014	RGDID:	1306035	Length:	491	Species:	Rattus norvegicus

Alignment Length:	310	Identity:	74/310 - (23%)
Similarity:	114/310 - (36%)	Gaps:	83/310 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 AATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDL 401
            |.|.:|||..|..:.      .:..|.:.:.|     ...::|::.:|.....|:.....|:.
  Rat    24 AGTPAAPPAPPAGHQ------VVHVRGDSETD-----LEALFNAVMNPKTANVPQTVPMRLRK-- 75

  Fly   402 RPVREAPGVPDIAITNPFTR---RAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILL 463
                    :||.....|..:   |.|...||.||....:       |::.|......|.....|
  Rat    76 --------LPDSFFKPPEPKSHSRQASTDAGTAGALTPQ-------HVRAHSSPASLQLGAGTL- 124

  Fly   464 DVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEE 528
                                         |.|...|..:|....::..:.:..:|        ::
  Rat   125 -----------------------------TASGVVSGPAATPAAQHLRQSSFEIP--------DD 152

  Fly   529 EPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNG---------RASPMPNQTRRVEDDLGPLPE 584
            .|||..|.|....:|:.:|::|..:.|||.|||..         .|||...|| .:....||||:
  Rat   153 VPLPAGWEMAKTSSGQRYFLNHNDQTTTWQDPRKAMLSQLNVPTSASPAVPQT-LMNSASGPLPD 216

  Fly   585 GWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIA---GQAVPYSRDYKQ 631
            |||:.:..||.|:||:|..:||.|.|||| :|...   .|.:..|...||
  Rat   217 GWEQAMTQDGEVYYINHKNKTTSWLDPRL-DPRFGKAMNQRITQSAPVKQ 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	10/28 (36%)
		WW	581..613	CDD:197736	17/31 (55%)
		HECTc	650..1003	CDD:238033
		HECTc	674..1003	CDD:214523
Yap1	XP_006242550.1	WW	156..185	CDD:238122	10/28 (36%)
Yap1	XP_006242550.1	WW	213..245	CDD:197736	17/31 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000