DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and Ube3a

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_001178766.1	Gene:	Ube3a / 361585	RGDID:	1306361	Length:	868	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	147/503 - (29%)
Similarity:	228/503 - (45%)	Gaps:	100/503 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   576 EDDLGPLPEG---------WEERVHTDG-RV--FYIDHNTRTTQWEDPRLSNPNIAGQAVPYSRD 628
            |||..|:||.         .|||.:..| ||  ...:...:|.....|.:|......:.:....:
  Rat   388 EDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETEIGVKTLDCRKPLISFEEFINEPLNDVLE 452

  Fly   629 YKQKYEYFKSHIRKPTNVPNKF------------------------------------------- 650
            ..:.|.:||      ....|||
  Rat   453 MDKDYTFFK------VETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQ 511

  Fly   651 -----EIRIRRTSILEDS---YRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEM 707
                 .:::||..|::|:   ..:|:.....| ||.:|:||||||.|:|.||:::|:|.|:.:|:
  Rat   512 LNPYLRLKVRRDHIIDDALVRLEMIAMENPAD-LKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEI 575

  Fly   708 FNPYYGLFEYSAMDNYT-LQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMM 771
            |||..|:|.|   |..| |...|.|....|   ..|..||.:.|:|:|:..:||..|....|:.:
  Rat   576 FNPDIGMFTY---DEATRLFWFNPSSFETE---GQFTLIGIVLGLAIYNNCILDVHFPMVVYRKL 634

  Fly   772 LQKP---IDLKDMESVDTEYYNSLMWIKENDPRI---LELTFCLDE-DVFGQKSQHELKPGGANI 829
            :.|.   .||.|...:   .|.||..:.|.:..:   :.:||.:.: |:||....::||..|..|
  Rat   635 MGKKGTFCDLGDSHPI---LYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKI 696

  Fly   830 DVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIK-IFDEHELELLMCGIQNIDVK 893
            .:||||:.|::.|..::.....|::|..:|..||..:...:.:| :|...|:|||:||.:|:|.:
  Rat   697 PITNENRKEFVSLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQ 761

  Fly   894 DWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNG---FKELYGSNGPQ 955
            ...|.|.|.|.|....::|:.||..|.||::|.:...|||.|||.|.|:.|   .|.:...|||.
  Rat   762 ALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPD 826

  Fly   956 MFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
                     ....|.:|||||.|.||.|....:||::|:|||..::||
  Rat   827 ---------TERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736	11/43 (26%)
		HECTc	650..1003	CDD:238033	125/415 (30%)
		HECTc	674..1003	CDD:214523	119/340 (35%)
Ube3a	NP_001178766.1	AZUL	27..81	CDD:406862
Ube3a	NP_001178766.1	HECTc	516..866	CDD:238033	126/369 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810