DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and Ufd4

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster

Alignment Length:	1446	Identity:	250/1446 - (17%)
Similarity:	410/1446 - (28%)	Gaps:	640/1446 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 GRTIGE-QSYTLRPRRSVGAKSRIKGT-LRIYHAFIRETREQSEPSSGNSDGE---------WEH 224
            |:::.| ::.|.|.||.:.|:.:...| .|:.........||...:.|...||         |:|
  Fly  1306 GKSVKEAEAKTRRERRQIRAQLKHMTTGARVIRGVDWRWEEQDGCAEGTITGEIHNGWIDVKWDH 1370

  Fly   225 --------------------VEATNA-------GETSAQPHPFPTGGH----------DALPAGW 252
                                .|..:|       |..|....|...||:          .:||...
  Fly  1371 GVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSRKSSSTPSLPEAT 1435

  Fly   253 EERQD---ANGRTYYVNHTA--RTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRS 312
            |:.|:   |:.:|...::.|  :|.:.....|..|..:|...:|||.:............|||.:
  Fly  1436 EKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAKTQIISNQLAMNTSSSREARAKHKESGTN 1500

  Fly   313 ---ADSIS------------------HNSIE--DNNNAAGLA----------------------- 331
               .|:||                  :||:.  :::|.:.||
  Fly  1501 QMHKDNISGPSPLSRELEHISDLSAINNSMPAINSSNVSDLATISENLSLTELSKENICRVLTPS 1565

  Fly   332 YTPK---TAATSSAPP--------------------NTPTNNNGILAQIA--------------- 358
            |.|.   ||:.||:.|                    |...|.|..:.:|:
  Fly  1566 YKPAESVTASQSSSHPDVQSSSPRENDIKNISNIEENNKMNANNSVNKISKDLLANLRTSNIAGC 1630

  Fly   359 -----MQYRAEEDQDPTVDHTSFVYN-----------------------------SLRHPVAHRQ 389
                 :...|.|..|...|....:.|                             :|.:|....|
  Fly  1631 PPVTQLSTEALEMIDKMRDGVDMIRNMSNSILSTDTFPVPCTNVPVGGKKTPKAQALINPDNANQ 1695

  Fly   390 PEISATSLQ----------NDLRP------------VREAP--------------GVPDIAITNP 418
            .:|..||.:          ..|:|            ::|.|              .||::..|:.
  Fly  1696 KQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTSA 1760

  Fly   419 FTRRAAGNMAGGAGWQQ-----ERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQ----- 473
            ....:...:|...|..:     .|||.....:||.:|....:...|      :|..|...
  Fly  1761 SEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVN------EHGDQNASGSFLG 1819

  Fly   474 ---------------HRGQRHQQQHRP--SNEDTDHTDSHNPSDISA----------------PS 505
                           |.|.....|..|  |:.::::....|||:.||                .|
  Fly  1820 HSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTINHTLTMSLTS 1884

  Fly   506 TRRNSEE-------DNAAVPPM----------------EQNTGGEEEPLPPRWSMQVAPNGRTFF 547
            |..:||:       ::...|.:                |:|....||.......:.|:.|..||.
  Fly  1885 TSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMVSRNLLTFM 1949

  Fly   548 IDHA--------SRRTTW----------------IDPRNGRAS----------------PMPNQT 572
            .|.|        ::|.:|                .|||.||.:                |.|.|:
  Fly  1950 DDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQS 2014

  Fly   573 ---RRVEDDL----------GPLPEGWEERVHTDGRVFYI------------------------- 599
               ..:|..|          |.:||...:..:||..:|..
  Fly  2015 GGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYT 2079

  Fly   600 ----------------------------------------------------------------- 599

  Fly  2080 IVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCSVDDVLELLTQ 2144

  Fly   600 --------------DH----------------NTRTTQWEDPRL--SN--PNIA---GQAVPYSR 627
                          :|                |....|.:||.:  ||  ||..   .|:.|:..
  Fly  2145 INGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLF 2209

  Fly   628 DYKQKYEYF-------------------------KSHIRKPTNVPNKFEI-RIRRTSIL----ED 662
            .::.:..||                         :..|..|....::|.| |::...:.    ||
  Fly  2210 PFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHERVKVPRNED 2274

  Fly   663 SYRIISSVTKTDL-LKTKLWVEF--EGETGLDYGGLAREWFYLLSKEMFNP-------------- 710
            .......|.||.. .|:.|.|||  |..|||   |...|::.|::.|:...
  Fly  2275 LLMWAMQVMKTHCNRKSVLEVEFLDEEGTGL---GPTLEFYALVAAEIQRSDLCMWLCDDDLGED 2336

  Fly   711 ----------------YY------GLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAV 753
                            ||      |:|......|        |.:| |..|.||.|.|......:
  Fly  2337 TENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQN--------SEIC-ENVLKYFWFFGVFVAKVL 2392

  Fly   754 YHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYN---------------------------- 790
            ...:|:|......|.:::....:..::::.|.::..|
  Fly  2393 QDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSN 2457

  Fly   791 ------SLMWIKENDPR------------------------------------------------ 801
                  ||..:||.||.
  Fly  2458 AFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSL 2522

  Fly   802 ---ILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGF 863
               .|..|:.....::|. :|.||.|.|::::||.:|.:.|.:|::.:.....:.:||.:|.|||
  Fly  2523 EDLALTFTYLPSSSIYGY-TQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGF 2586

  Fly   864 GSIIPLNLIKIFDEHELELLMCGIQ-----NIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFS 923
            ..:.||..:..|...|..:::||.|     ..|:..:.|..|   .|:.:....|.|...:||.|
  Fly  2587 NEVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISYTEPKL---GYNKDSPGFQRFVNVLLSMS 2648

  Fly   924 NEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGT-PNNFPRAHTCFNRLDLPPYEGYL 987
            .:.|...|||.||.|.:|..|...|:    |::..:.|... ..::|..:||.:.|.||.|....
  Fly  2649 GDERKAFLQFTTGCSSLPPGGLANLH----PRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTEE 2709

  Fly   988 QLKDKLIKAIEGSQGF 1003
            .:|::|:.|.: .:||
  Fly  2710 IMKERLLTATK-EKGF 2724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	9/34 (26%)
		WW	248..277	CDD:278809	8/33 (24%)
		WW	531..560	CDD:278809	8/52 (15%)
		WW	581..613	CDD:197736	10/151 (7%)
		HECTc	650..1003	CDD:238033	102/487 (21%)
		HECTc	674..1003	CDD:214523	94/458 (21%)
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955	8/55 (15%)
		DamX	1576..>1725	CDD:330571	20/148 (14%)
		HECTc	2265..2725	CDD:238033	101/481 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446996
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830