DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nedd4 and Hecw2

DIOPT Version :10

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:NP_001001883.1 Gene:Hecw2 / 329152 MGIID:2685817 Length:1578 Species:Mus musculus


Alignment Length:990 Identity:307/990 - (31%)
Similarity:439/990 - (44%) Gaps:267/990 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   160 LTLVNLPTEQEGRTIGEQSYTLRPRRSVGAKSRIKGTLR-----IYHAFIRETREQSEPSSGNSD 219
            |..|.:|:.:|..:..|.: .|..:..:|...:.:|:|.     ...|...:::.|.:..:|::.
Mouse   707 LPAVQVPSREEEGSAAEAA-ALSEQGELGEVWQRRGSLEGAAAAAPAAAATDSQPQEDGDAGDAQ 770

  Fly   220 GEWEHVEATNAGETSAQPHPFPTGGH--------------------DALPAGWEERQDANGRTYY 264
            |..|...|...|.|...    .|.||                    :|||..||.|.|::||.:|
Mouse   771 GACEGATAQEEGATGGS----QTNGHQPLRSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFY 831

  Fly   265 VNHTARTTQWDRPT------VLNSHSSQSTDDQLASDFQ--RRFHISVDDTESGRSADSISHNSI 321
            |:|..|||.|.|||      ||...:|....:||...:|  ||               ::::...
Mouse   832 VDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRR---------------TMTNERP 881

  Fly   322 EDNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVA 386
            |:|           |:|...|      .......|.:..:|.|              |.|.|..:
Mouse   882 EEN-----------TSAIDGA------GEEADFHQASADFRRE--------------NVLPHSTS 915

  Fly   387 HRQPEISATSLQNDLRPVR--EAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQH 449
            .     |..:|.....||:  .:|....:..:||...|...|                       
Mouse   916 R-----SRLTLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTN----------------------- 952

  Fly   450 QQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDN 514
                     |..|..:..:.:...|..:|:|               ||...:...:...|.:.: 
Mouse   953 ---------NTCLKHMITKVRRDTHHFERYQ---------------HNRDLVGFLNMFANKQLE- 992

  Fly   515 AAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPR----NGRAS--------- 566
                            ||..|.|:....|:.||:||.||.||:||||    :.|.:         
Mouse   993 ----------------LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHL 1041

  Fly   567 -----------------------PMPNQT-----RRVEDDLGPLP---------------EGWEE 588
                                   |.|:.|     |....|:.|:.               |..:|
Mouse  1042 TRQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYNDKIVAFLRQPNILEILQE 1106

  Fly   589 R----------------VHTDGR-----------------------VFYIDHNT--RTTQWEDPR 612
            |                :.|:|.                       :.|:..:.  ..:..:.||
Mouse  1107 RQPDLARNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQSPR 1171

  Fly   613 ---LSNP-NIAG-------QAVPYSRDYKQKYE--YFKSHIRKPTNVPNKFEIRIRRTSILEDSY 664
               :|:| |..|       ...||.||::.|..  |.|...:.....|.|.::.|||..:|||::
Mouse  1172 GSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAF 1236

  Fly   665 RIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINN 729
            ..|...::.||.:.||:|.|.||.||||.|.:||:|:|:|:|:||||||||||||.|.||:||:.
Mouse  1237 NQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISP 1301

  Fly   730 GSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMW 794
            .|...:..| .:|:|.|||.|:|:.|..||||||.|||||.:|:...||.|:|.:|.|::.||.|
Mouse  1302 MSAFVDNHH-EWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQW 1365

  Fly   795 IKENDPR-ILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSS 858
            :|:||.. ||:|||.::|:||||.::.|||||||||.||.:||.|||:.:::||....|.:|..|
Mouse  1366 MKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTES 1430

  Fly   859 FLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFS 923
            .:.||..::...|:.:||..||||::.|...||:.|||.||.|:|.||.|||:|:|||.||..|:
Mouse  1431 LVRGFYEVVDARLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDNHIVIRWFWAAVERFN 1495

  Fly   924 NEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQ 988
            ||.|.||||||||||.:|..||..|.|||||:.|.:||||.....|||||||||||||||..:..
Mouse  1496 NEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSM 1560

  Fly   989 LKDKLIKAIEGSQGF 1003
            |.:||:.|:|.:..|
Mouse  1561 LYEKLLTAVEETSTF 1575

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 10/48 (21%)
WW 248..277 CDD:459800 15/28 (54%)
HUL4 <523..1003 CDD:227354 231/590 (39%)
Hecw2NP_001001883.1 HECW_N 45..162 CDD:465177
C2_NEDL1-like 185..320 CDD:176073
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..453
DMP1 <344..700 CDD:462128
NESP55 <463..639 CDD:115071
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..802 20/99 (20%)
Interaction with TP73. /evidence=ECO:0000250 737..1074 89/455 (20%)
WW 815..844 CDD:459800 15/28 (54%)
HECW1_helix 921..987 CDD:465766 15/112 (13%)
WW 993..1024 CDD:197736 16/30 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1030..1075 4/44 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1167..1193 6/25 (24%)
HECTc 1222..1576 CDD:238033 187/355 (53%)
Blue background indicates that the domain is not in the aligned region.

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