DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and CG42797

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	901	Identity:	302/901 - (33%)
Similarity:	417/901 - (46%)	Gaps:	197/901 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 EPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGHDALPAGWEERQDANGRTYYVNHTARTTQWDR 276
            ||.:|...|      ::.||          ..|...||..||.|.|::||.:|::||.|||.|.|
  Fly   618 EPGTGTVSG------SSGAG----------AAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQR 666

  Fly   277 PTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLAYTPKTAATSS 341
            |....|......:........||:             .|| ..:|.:.:.||.| |...|:|.|:
  Fly   667 PGAAPSGGPAGREQHHRQQLDRRY-------------QSI-RRTITNESRAAQL-YNLPTSANSN 716

  Fly   342 A---PPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTS----FVYN---SLRHPV--AHRQPE-IS 393
            |   .|..|.....|...|.|..|.:   ..::.||:    .:||   :|:|.|  ..|.|. ..
  Fly   717 ANSTAPAAPPPATAIHPAILMLCRPD---FYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQ 778

  Fly   394 ATSLQNDLRPVREAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQ 458
            ......||           :|:.|.|   |..:....:.|:.:..:...|..| .||.|:.....
  Fly   779 RYQYNKDL-----------VALVNTF---AQMSRELPSCWETKLDQSGKQFFI-DHQHRRTSFMD 828

  Fly   459 NRILLD----VDHRQQEPQHRGQRHQQQH------------------------------------ 483
            .|:.::    |.||||        |.||.
  Fly   829 PRLPVECPRVVRHRQQ--------HSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVPP 885

  Fly   484 ----RPSNED----TDHTDSHNPSDISAPSTRRNSEED--NAAVPPMEQNTGGEEEPLPPRWSMQ 538
                |||:..    :.|...||.:..||.|...|::..  .||.......|....|.:|..::.:
  Fly   886 LPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEK 950

  Fly   539 V-----APNGRTFFIDHASRRTTWIDPRNGRASPMPNQTR------RVE---------------- 576
            |     .||......:...:.|            |..|.|      |||
  Fly   951 VIAFLRQPNILEILRERQGQHT------------MSRQLREKINILRVEGVPALERLGHDLQLTI 1003

  Fly   577 -------DDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYE 634
                   :.:|.:|  .|||......|.    |:|..|...|            |:.||::.|
  Fly  1004 LLSLFEQEIMGFVP--IEERSPQGSPVL----NSRMPQRAPP------------PFRRDFEAK-- 1048

  Fly   635 YFKSHIRKPTNV-----PNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGG 694
             .:|..||..:.     |:|.::.|||:.:|||::|.|.|..|.||.:.:|.|.::.|.||||||
  Fly  1049 -LRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGG 1112

  Fly   695 LAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLL 759
            .:||:|:|||:|:||||||||||||.|.||:|::..|...:..| .:|:|.||:.|:|:.|..||
  Fly  1113 PSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCH-DWFRFSGRVLGLALVHQYLL 1176

  Fly   760 DAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRI---LELTFCLDEDVFGQKSQHE 821
            ||||.|||||.:|:.|:.|.|:||:|.|::.||.||::||...   |.||||:.|::.|.....|
  Fly  1177 DAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRE 1241

  Fly   822 LKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCG 886
            |||||.||.:..:||.||::.:|:||....|:||..|.:.||..:|...|:.:||..||||::.|
  Fly  1242 LKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAG 1306

  Fly   887 IQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGS 951
            ...||..|||.||.|:..||.||.:|.|||:.:..||||.|.||||||||||.:|..||..|.||
  Fly  1307 TAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGS 1371

  Fly   952 NGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGFAGVD 1007
            .||:.|.|||||.||..|||||||||||||||.....|.:||:.|:|.:..| |::
  Fly  1372 TGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTF-GIE 1426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809	15/28 (54%)
		WW	531..560	CDD:278809	5/33 (15%)
		WW	581..613	CDD:197736	9/31 (29%)
		HECTc	650..1003	CDD:238033	182/355 (51%)
		HECTc	674..1003	CDD:214523	172/331 (52%)
CG42797	NP_572574.2	WW	638..667	CDD:278809	15/28 (54%)
		HECTc	1068..1424	CDD:238033	183/357 (51%)
		HECTc	1092..1423	CDD:214523	172/331 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446995
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840