Protein Alignment Nedd4 and Smurf2

DIOPT Version :10

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: NP_001100531.1
• Gene: Smurf2 / 303614
• RGDID: 1310067
• Length: 748
• Species: Rattus norvegicus
• Alignment Length: 984
• Identity: 314/984 - (31%)
• Similarity: 429/984 - (43%)
• Gaps: 302/984 - (30%)

  Fly    72 LRIVVLTGQSLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTKKKTLNPTWNEEFIFRVKPSE 136
            ||:.||..::|.|||.|...||:.::   .::|.....|  |.|.|.||:|.||:.:...:..|:
  Rat    14 LRLTVLCAKNLVKKDFFRLPDPFAKV---VVDGSGQCHS--TDTVKNTLDPKWNQHYDLYIGKSD 73

  Fly   137 HKLVFQVFDENRLTRDD---FLGMV----------------ELTLVNLPTEQEGRTIGEQSYTLR 182
             .:...|::..::.:..   |||.|                .|.|..|.........|:...:|:
  Rat    74 -SVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQ 137

  Fly   183 PRRSVGAKSRIKGTLRIYHAFIRETREQSEPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGHDA 247
            .|..:|...::....|::                  |.:
  Rat   138 SRDRIGTGGQVVDCSRLF------------------DND-------------------------- 158

  Fly   248 LPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRS 312
            ||.|||||:.|:||..|:||..|||||:|||                                |.
  Rat   159 LPDGWEERRTASGRIQYLNHITRTTQWERPT--------------------------------RP 191

  Fly   313 ADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTP-TNNNGILAQIAMQYRAEEDQDPTVDHTSF 376
            |...|               :|....:.....||| |..||
  Rat   192 ASEYS---------------SPGRPLSCFVDENTPITGTNG------------------------ 217

  Fly   377 VYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQ 441
                             ||..|:.
  Rat   218 -----------------ATCGQSS----------------------------------------- 224

  Fly   442 MQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPST 506
                                    |.|..|.:.|.|||:..       ...|..|.|.|
  Rat   225 ------------------------DPRLAERRVRSQRHRNY-------MSRTHLHTPPD------ 252

  Fly   507 RRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQ 571
                                    ||..:..:....|:.:|:...:..:||.|||      :|..
  Rat   253 ------------------------LPEGYEQRTTQQGQVYFLHTQTGVSTWHDPR------VPRD 287

  Fly   572 TRRVE-DDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLS---------NPNIAGQ----- 621
            ...:. ::|||||.|||.|....|||:::|||.||||:.|||||         ...:..|
  Rat   288 LSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQV 352

  Fly   622 -----------AVP-YSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTD 674
                       .|| |.||..||.:..:..:.:.........|.:.|..|.|:|||.:..:...|
  Rat   353 VSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKD 417

  Fly   675 LLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHL 739
            |.| :|.::|.||.||||||:||||.||||.||.|||||||:||..|.||||||..|.: |.|||
  Rat   418 LWK-RLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHL 480

  Fly   740 SYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEND-PRIL 803
            |||.|:|||.||||:||..:|..|..||||.:|.|.|.|.|||.||.:.:|||:||.||| ..:|
  Rat   481 SYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVL 545

  Fly   804 ELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIP 868
            :.|||::.:.:|:..||||||.|.:|.||.|||.||::|.:.|||:..::.|..:...||..:||
  Rat   546 DHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIP 610

  Fly   869 LNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHM--NHIIIQWFWRAVLSFSNEMRSRLL 931
            .:|:|.|||.||||::||:..|||.||:.||..|   |.  :..:::|||:||..|..|.|:|||
  Rat   611 QHLLKTFDEKELELIICGLGKIDVSDWKANTRLK---HCTPDSNVVKWFWKAVELFDEERRARLL 672

  Fly   932 QFVTGTSRVPMNGFKELYGSNGPQMFTIEKW-GTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIK 995
            |||||:||||:.|||.|.|:.||::|||.:. ...||.|:|||||||:|:||||.|.:|.:||:.
  Rat   673 QFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLT 737

  Fly   996 AIEGSQGFA 1004
            |||.:.|||
  Rat   738 AIEETCGFA 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	35/150 (23%)
		WW	248..277	CDD:459800	18/28 (64%)
		HUL4	<523..1003	CDD:227354	230/510 (45%)
Smurf2	NP_001100531.1	C2_Smurf-like	13..137	CDD:176028	31/128 (24%)
		PRP40	155..>236	CDD:227435	39/277 (14%)
		WW	159..188	CDD:459800	18/28 (64%)
		WW	252..283	CDD:197736	8/60 (13%)
		WW	298..330	CDD:197736	19/31 (61%)
		HECTc	393..745	CDD:238033	188/356 (53%)