DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and Smurf2

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_001100531.1	Gene:	Smurf2 / 303614	RGDID:	1310067	Length:	748	Species:	Rattus norvegicus

Alignment Length:	984	Identity:	314/984 - (31%)
Similarity:	429/984 - (43%)	Gaps:	302/984 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 LRIVVLTGQSLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTKKKTLNPTWNEEFIFRVKPSE 136
            ||:.||..::|.|||.|...||:.::   .::|.....|  |.|.|.||:|.||:.:...:..|:
  Rat    14 LRLTVLCAKNLVKKDFFRLPDPFAKV---VVDGSGQCHS--TDTVKNTLDPKWNQHYDLYIGKSD 73

  Fly   137 HKLVFQVFDENRLTRDD---FLGMV----------------ELTLVNLPTEQEGRTIGEQSYTLR 182
             .:...|::..::.:..   |||.|                .|.|..|.........|:...:|:
  Rat    74 -SVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQ 137

  Fly   183 PRRSVGAKSRIKGTLRIYHAFIRETREQSEPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGHDA 247
            .|..:|...::....|::                  |.:
  Rat   138 SRDRIGTGGQVVDCSRLF------------------DND-------------------------- 158

  Fly   248 LPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRS 312
            ||.|||||:.|:||..|:||..|||||:|||                                |.
  Rat   159 LPDGWEERRTASGRIQYLNHITRTTQWERPT--------------------------------RP 191

  Fly   313 ADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTP-TNNNGILAQIAMQYRAEEDQDPTVDHTSF 376
            |...|               :|....:.....||| |..||
  Rat   192 ASEYS---------------SPGRPLSCFVDENTPITGTNG------------------------ 217

  Fly   377 VYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQ 441
                             ||..|:.
  Rat   218 -----------------ATCGQSS----------------------------------------- 224

  Fly   442 MQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPST 506
                                    |.|..|.:.|.|||:..       ...|..|.|.|
  Rat   225 ------------------------DPRLAERRVRSQRHRNY-------MSRTHLHTPPD------ 252

  Fly   507 RRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQ 571
                                    ||..:..:....|:.:|:...:..:||.|||      :|..
  Rat   253 ------------------------LPEGYEQRTTQQGQVYFLHTQTGVSTWHDPR------VPRD 287

  Fly   572 TRRVE-DDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLS---------NPNIAGQ----- 621
            ...:. ::|||||.|||.|....|||:::|||.||||:.|||||         ...:..|
  Rat   288 LSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQV 352

  Fly   622 -----------AVP-YSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTD 674
                       .|| |.||..||.:..:..:.:.........|.:.|..|.|:|||.:..:...|
  Rat   353 VSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKD 417

  Fly   675 LLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHL 739
            |.| :|.::|.||.||||||:||||.||||.||.|||||||:||..|.||||||..|.: |.|||
  Rat   418 LWK-RLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHL 480

  Fly   740 SYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEND-PRIL 803
            |||.|:|||.||||:||..:|..|..||||.:|.|.|.|.|||.||.:.:|||:||.||| ..:|
  Rat   481 SYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVL 545

  Fly   804 ELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIP 868
            :.|||::.:.:|:..||||||.|.:|.||.|||.||::|.:.|||:..::.|..:...||..:||
  Rat   546 DHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIP 610

  Fly   869 LNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHM--NHIIIQWFWRAVLSFSNEMRSRLL 931
            .:|:|.|||.||||::||:..|||.||:.||..|   |.  :..:::|||:||..|..|.|:|||
  Rat   611 QHLLKTFDEKELELIICGLGKIDVSDWKANTRLK---HCTPDSNVVKWFWKAVELFDEERRARLL 672

  Fly   932 QFVTGTSRVPMNGFKELYGSNGPQMFTIEKW-GTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIK 995
            |||||:||||:.|||.|.|:.||::|||.:. ...||.|:|||||||:|:||||.|.:|.:||:.
  Rat   673 QFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLT 737

  Fly   996 AIEGSQGFA 1004
            |||.:.|||
  Rat   738 AIEETCGFA 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	35/150 (23%)
		WW	248..277	CDD:278809	18/28 (64%)
		WW	531..560	CDD:278809	6/28 (21%)
		WW	581..613	CDD:197736	19/31 (61%)
		HECTc	650..1003	CDD:238033	188/356 (53%)
		HECTc	674..1003	CDD:214523	181/332 (55%)
Smurf2	NP_001100531.1	C2_Smurf-like	13..137	CDD:176028	31/128 (24%)
		PRP40	155..>236	CDD:227435	39/277 (14%)
		WW	159..188	CDD:395320	18/28 (64%)
		WW	252..283	CDD:197736	8/60 (13%)
		WW	298..330	CDD:197736	19/31 (61%)
		HECTc	393..745	CDD:238033	188/356 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810