Protein Alignment Nedd4 and Wwp1

DIOPT Version :9

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: XP_006237992.1
• Gene: Wwp1 / 297930
• RGDID: 1311734
• Length: 968
• Species: Rattus norvegicus
• Alignment Length: 1112
• Identity: 344/1112 - (30%)
• Similarity: 490/1112 - (44%)
• Gaps: 369/1112 - (33%)

  Fly    58 RSLAAVNDSGDSCHLRIVVLTGQSLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTKK--KTL 120
            ||..:.|.|| ...|::.|.:.:...||:.||.:          |..::.:|..:.||.|  .:.
  Rat    57 RSDTSDNHSG-RLQLKVTVSSAKLKRKKNWFGTA----------IYTEVIVDGEIKKTAKSSSSS 110

  Fly   121 NPTWNEEFIFRVKPSEHKLVFQVFDENRLTRDDFLG----------------------MVELTLV 163
            ||.|:|:.|..|.| :..|.|:|:..:.|..|..||                      .::|:|.
  Rat   111 NPKWDEQLIVNVAP-QTTLEFRVWSHHTLKADALLGKATVDLKQVLLTHNRKLEKVKEQLKLSLE 174

  Fly   164 N---------LPTEQEGRTIGEQSYTLR--------------------PRRSVGAKSRIKGTLRI 199
            |         |....:|..|..::.|.|                    |......:..::||:.|
  Rat   175 NKNGIVQTGELTVVLDGLVIEPEAVTNRSSSPPIEIQQNGDAVHENGDPLTRTTPRLAVEGTIGI 239

  Fly   200 ---------------YHAFIRE----------TREQ---------SEPSSGNSDGEWEHVEA--- 227
                           .|....|          ||.|         |||:|...:||...|.|
  Rat   240 DNHVSTSTVVPSSCCSHIVNGENTPSSPPQVATRPQNTPAPKPLTSEPTSDTVNGESSSVLADST 304

  Fly   228 ---------------TNAGETSAQPHPF------------------------------------- 240
                           :|...|:.|..|.
  Rat   305 SAMGTSLPSEDSTSTSNCTSTTVQEPPVQEPPASSEHSECIPSASAEVGPEARSLIDPDSDSRNN 369

  Fly   241 -----------------PTGGH---DALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSS 285
                             |..|:   ::||:|||:|:|.:||||||:|..|||.|:||
  Rat   370 SGFDKVRQPEGCVEPLRPQSGNTNTESLPSGWEQRKDPHGRTYYVDHNTRTTTWERP-------- 426

  Fly   286 QSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNN 350
                ..|...::||    |||  .|| ...:.||:
  Rat   427 ----QPLPPGWERR----VDD--RGR-VYYVDHNT------------------------------ 450

  Fly   351 NGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAI 415
                       |....|.||::                       |::|
  Rat   451 -----------RTTTWQRPTME-----------------------SVRN---------------- 465

  Fly   416 TNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQ 480
               |.:           ||.:  |.|:|..:||..||...
  Rat   466 ---FEQ-----------WQSQ--RNQLQGAMQQFNQRYLY------------------------- 489

  Fly   481 QQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRT 545
                                             :|::...|.:..|   ||||.|..:|....|.
  Rat   490 ---------------------------------SASMLAAENDPYG---PLPPGWEKRVDSTDRV 518

  Fly   546 FFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWED 610
            :|::|.::.|.|.||   |...:||:.        |||||||.|...:|..:::|||||||.::|
  Rat   519 YFVNHNTKTTQWEDP---RTQGLPNEE--------PLPEGWEIRYTREGVRYFVDHNTRTTTFKD 572

  Fly   611 PRLSNPNI--AGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKT 673
            ||....::  .|..:.|.|.::.|..:|: ::.:...:|:..:|.:.|.::.|||::.|.::...
  Rat   573 PRNGKSSVTKGGPQIAYERSFRWKLAHFR-YLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPY 636

  Fly   674 DLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEH 738
            | |:.:|:|.|.||.||||||||||||:|||.|:.||.|.||||:..:||.||||..|.: |.:|
  Rat   637 D-LRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDH 699

  Fly   739 LSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRI- 802
            ||||.||||...||::|||.:|..|..||||.||.|.:.:||:||:|||:||||:||::|:...
  Rat   700 LSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEEC 764

  Fly   803 -LELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSI 866
             ||:.|.:|.::.|:.:.|:||.||:||.||.|||||||.|:.||||...|:||..:|||||..:
  Rat   765 GLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEV 829

  Fly   867 IPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLL 931
            :||..::.|||.|||:::||:|.:|:.||:.||:|: .|..|...|.|||:.|....||:|.|||
  Rat   830 VPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYR-HYTRNSKQIIWFWQFVKETDNEVRMRLL 893

  Fly   932 QFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKA 996
            ||||||.|:|:.||.||.||||||.|.|||.|.....||:||||||||||||:.|.|||:||:.|
  Rat   894 QFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFA 958

  Fly   997 IEGSQGF 1003
            ||.::||
  Rat   959 IEETEGF 965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	38/200 (19%)
		WW	248..277	CDD:278809	18/28 (64%)
		WW	531..560	CDD:278809	10/28 (36%)
		WW	581..613	CDD:197736	18/31 (58%)
		HECTc	650..1003	CDD:238033	191/354 (54%)
		HECTc	674..1003	CDD:214523	185/330 (56%)
Wwp1	XP_006237992.1	C2_E3_ubiquitin_ligase	67..190	CDD:175988	29/133 (22%)
		PARM	243..>400	CDD:293666	21/156 (13%)
		WW	397..426	CDD:278809	18/28 (64%)
		WW	429..458	CDD:278809	12/76 (16%)
		WW	504..533	CDD:278809	10/28 (36%)
		WW	545..574	CDD:238122	15/28 (54%)
		HECTc	614..966	CDD:238033	193/355 (54%)
		HECTc	637..965	CDD:214523	185/330 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.710