DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and Nedd4l

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_038952600.1	Gene:	Nedd4l / 291553	RGDID:	735047	Length:	1259	Species:	Rattus norvegicus

Alignment Length:	949	Identity:	443/949 - (46%)
Similarity:	569/949 - (59%)	Gaps:	145/949 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 TRDDFLGMVELTLVNLPTEQEGRTIGEQSYT-----LRPRRSVGAKSRIKGTLRIYHAFIRETRE 209
            |||||||.|::.|.:||||....   |:.||     ||||   ..|||:||.||:..|::.:...
  Rat   365 TRDDFLGQVDVPLSHLPTEDPTM---ERPYTFKDFLLRPR---SHKSRVKGFLRLKMAYMPKNGG 423

  Fly   210 QSEPSSGNSDG---EWEHVEATNAGETSAQPHPFPTGGHDALPAGWEERQDANGRTYYVNHTART 271
            |.|.:|...|.   .||.|::.::.....:..|.|     .||.||||:.|..||||||||..|:
  Rat   424 QDEENSEQRDDMEHGWEVVDSNDSASQHQEELPPP-----PLPPGWEEKVDNLGRTYYVNHNNRS 483

  Fly   272 TQWDRPTVLN-SHSSQSTDDQLASD-----FQRRFHISVD---DTESGRSADSISHNSIEDNNNA 327
            |||.||:::: |..|.:...|:..:     |:.|.|||.|   :...|.........:|.:..|.
  Rat   484 TQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEASEGGGEGPEPWETISEEVNM 548

  Fly   328 AG----LAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEE---DQDPTVDHTSFVYNSL--RH 383
            ||    ||..|        ||.:|      :::.:.|..:||   ....|.|.....:::|  |.
  Rat   549 AGDSLSLALPP--------PPASP------VSRTSPQELSEELSRRLQITPDSNGEQFSALIQRE 599

  Fly   384 PVAHRQPEISATSL---QNDLRPVREAPGVPDIAITNPFTRRA-AGNMAGG-------------- 430
            | :.|....|.|..   |..|.|    |..|        |||| :..:.||
  Rat   600 P-SSRLRSCSVTDTVAEQAHLPP----PSTP--------TRRARSSTVTGGEESTPSVAYVHTTP 651

  Fly   431 ---AGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVD----------HRQQEPQHRGQRHQQQ 482
               :|| :||:..:.:.:...|..|.....:..:.|..|          :...|||.|
  Rat   652 GLPSGW-EERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLVEPQIR------- 708

  Fly   483 HRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVP----PMEQNTGGEEEP-----LPPRWSMQ 538
             ||.:..:.......|.:.:..|..|.:.:|..:.|    |...|:...:..     |||.|.|:
  Rat   709 -RPRSLSSPTVTLSAPLEGAKDSPIRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 772

  Fly   539 VAPNGRTFFIDHASRRTTWIDPR-------NGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRV 596
            :|||||.|||||.::.|||.|||       ..:||..||       ||||||.|||||:|.|||.
  Rat   773 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPN-------DLGPLPPGWEERIHLDGRT 830

  Fly   597 FYIDH------------------NTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYEYFKSHIRKP 643
            |||||                  :::.||||||||.||.|.|.||||||::||||:||:..::||
  Rat   831 FYIDHSSQVLCGENDTRESVPLYDSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKP 895

  Fly   644 TNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMF 708
            .::||:||:::.|.:|.|:|||.|.||.:.|:||.:||:|||.|.||||||:|||||:|||||||
  Rat   896 ADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMF 960

  Fly   709 NPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQ 773
            |||||||||||.||||||||..||||||:|||||.||||:||:||:||||||.|||||||||||.
  Rat   961 NPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 1025

  Fly   774 KPIDLKDMESVDTEYYNSLMWIKENDPRILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDE 838
            |.|.|.||||||:||||||.||.||||..|:|.||:||:.|||..|.:|||.|:.|.||||||.|
  Rat  1026 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKRE 1090

  Fly   839 YIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKG 903
            ||.|||:||||.||::||::||:||..::|::|||||||:||||||||:.::||.|||::::||.
  Rat  1091 YIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKN 1155

  Fly   904 DYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNF 968
            .|..||.:|||||:|||....|.|.|||||||||||||||||.|||||||||:||||:||:|...
  Rat  1156 GYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKL 1220

  Fly   969 PRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGFAGVD 1007
            ||||||||||||||||.:..|::||:.|:|.:|||.|||
  Rat  1221 PRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 1259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	28/58 (48%)
		WW	248..277	CDD:278809	19/28 (68%)
		WW	531..560	CDD:278809	18/28 (64%)
		WW	581..613	CDD:197736	23/49 (47%)
		HECTc	650..1003	CDD:238033	244/352 (69%)
		HECTc	674..1003	CDD:214523	233/328 (71%)
Nedd4l	XP_038952600.1	C2	<365..418	CDD:417471	28/58 (48%)
		WW	463..489	CDD:395320	17/25 (68%)
		WW	653..682	CDD:395320	6/29 (21%)
		WW	766..796	CDD:238122	19/29 (66%)
		WW	815..865	CDD:197736	23/49 (47%)
		HECTc	926..1255	CDD:214523	233/328 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	463	1.000	Domainoid score	I454
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86986
Inparanoid	1	1.050	866	1.000	Inparanoid score	I397
OMA	1	1.010	-	-		QHG49869
OrthoDB	1	1.010	-	-		D142537at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm45750
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1682
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840