DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and Hecw1

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_017455974.1	Gene:	Hecw1 / 291209	RGDID:	1561038	Length:	1603	Species:	Rattus norvegicus

Alignment Length:	959	Identity:	291/959 - (30%)
Similarity:	420/959 - (43%)	Gaps:	281/959 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 EPSSGNSDGEWEHVEAT---NAGET-----------------------SAQP-----------HP 239
            :|.|.|..|.|:...|.   ||..|                       ::||           |.
  Rat   756 DPESTNGAGPWQDELAAPGGNAARTTEGLDSPMAGPSNRREGDCPMLHNSQPISQLPSLRPEHHH 820

  Fly   240 FPTGGHDALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLAS-------DFQ 297
            :|| ..:.||..||.|.|::||.:||:|..|||.|.||::     :.:.|..:.|       ...
  Rat   821 YPT-IDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPSM-----APTPDGMIRSGSVHQMEQLN 879

  Fly   298 RRFHISVDDTESGRSADSISHNSIED-NNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQY 361
            ||:........:.||.:...:.|.|. .:..||...:...|.:|.:  |......|.|:.:
  Rat   880 RRYQNIQRTIATERSEEDSGNQSCEQIPDGGAGGGGSDSEAESSQS--NLDLRREGSLSPV---- 938

  Fly   362 RAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNP--FTRRAA 424
                             ||.:..:..:.|.:.                    .||||  ||...|
  Rat   939 -----------------NSQKVTLLLQSPAVK--------------------FITNPEFFTVLHA 966

  Fly   425 GNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLD-----VDHRQQEPQHRGQRHQQQHR 484
             |.:....:......:.|.|.:::..:..::.|.||.|::     .|.|.:
  Rat   967 -NYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLE-------------- 1016

  Fly   485 PSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFID 549
                                                          ||..|.::....|::||:|
  Rat  1017 ----------------------------------------------LPRGWEIKTDHQGKSFFVD 1035

  Fly   550 HASRRTTWIDPR----NGRASPMPN-----------------QTRRVEDDLG------------- 580
            |.||.||:||||    |||   :||                 :...|..:.|
  Rat  1036 HNSRATTFIDPRIPLQNGR---LPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLIA 1097

  Fly   581 ---------PLPEGWEERV-----------------------HT-DGRVFYI----DHNTRTTQW 608
                     .||..:.:::                       || ..::.||    :|.......
  Rat  1098 AIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSC 1162

  Fly   609 E------------------------------DPRLS-------NPNI----AGQAVPYSRDYKQK 632
            :                              .||.|       :|.:    |....||.||::.|
  Rat  1163 DADLVILLSLFEEEIMSYVPLQSAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAK 1227

  Fly   633 YE--YFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGL 695
            ..  |.|...:.....|.|.::.|||..:||.::..:.:.::.:|.:.||::.|.||.||||.|.
  Rat  1228 LRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGP 1292

  Fly   696 AREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLD 760
            :||:|:|||:|:||||||||||||.|.||:||:..|... |.:|.:|:|.|||.|:|:.|..|||
  Rat  1293 SREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENYLEWFRFSGRILGLALIHQYLLD 1356

  Fly   761 AFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEND-PRILELTFCLDEDVFGQKSQHELKP 824
            |||.|||||.:|:.|.||.|:|.:|.|::.||.|:|:|: ..||:|||.::|:||||.::.|||.
  Rat  1357 AFFTRPFYKGLLKLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKS 1421

  Fly   825 GGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQN 889
            ||||..||.:||.|||:.:::||....|.:|..:.:.||..::...|:.:||..||||::.|...
  Rat  1422 GGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAE 1486

  Fly   890 IDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGP 954
            ||:.|||.||.|:|.||..|::|:|||.||..|:||.|.||||||||||.||..||..|.||||.
  Rat  1487 IDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGL 1551

  Fly   955 QMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            :.|.|||||...:.|||||||||||||||..|..|.:||:.|:|.:..|
  Rat  1552 RRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSTLYEKLLTAVEETSTF 1600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809	15/28 (54%)
		WW	531..560	CDD:278809	13/28 (46%)
		WW	581..613	CDD:197736	8/89 (9%)
		HECTc	650..1003	CDD:238033	181/353 (51%)
		HECTc	674..1003	CDD:214523	176/329 (53%)
Hecw1	XP_017455974.1	HECW_N	66..185	CDD:293170
		C2_NEDL1-like	206..342	CDD:176073
		WW	827..857	CDD:197736	15/29 (52%)
		WW	1017..1048	CDD:197736	15/30 (50%)
		HECTc	1247..1601	CDD:238033	182/355 (51%)
		HECTc	1271..1600	CDD:214523	176/329 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810