DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and Hectd4

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_006530414.1	Gene:	Hectd4 / 269700	MGIID:	3647820	Length:	4525	Species:	Mus musculus

Alignment Length:	1294	Identity:	245/1294 - (18%)
Similarity:	415/1294 - (32%)	Gaps:	455/1294 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSARSSGLVAAAA--LPVPSSSSSVAGGDVPRPP-----------PRRRAASVAGQQQTRQEFGN 52
            :|..:||:.:...  |...|||||.:.|..|:.|           .|.:|:|...:|.:|....:
Mouse  3381 ISVTASGVTSTTTPNLSDSSSSSSSSPGQTPQSPSLLSKRKKVKMKREKASSSNKRQSSRASDAD 3445

  Fly    53 -------GYTPR-----------------------RSLAAVNDS-GDSC--------HLRIVVLT 78
                   |..|.                       :.|...:|: .|:|        |.|::|::
Mouse  3446 STVLSIGGSKPEDMLWFHRALTLLIILRHLTKKDPQGLGVTSDAIADACQALVGPTAHSRLLVIS 3510

  Fly    79 G--QSLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTKKKTLNPTWNEEFIFRVKPSEHKLVF 141
            |  ..|.:..:.||    :|...|. :|.:..|.:..        |..:|:      |.:.|...
Mouse  3511 GIPTHLDEAVVRGA----IRKACNA-HGGVFKDEIYI--------PLQDED------PKKPKDKA 3556

  Fly   142 QVFDENRLTRDDFLGMVELTLVNLPTEQEGRTIGEQSYTLRPRRSVGAKSRIKGTLRIYHAFIRE 206
            :..| :::..:..||...:..:      ||.|    |.:|.|..|:.|.:              .
Mouse  3557 EGSD-SKVESEKLLGFPSVDSL------EGST----SSSLAPAMSISASA--------------S 3596

  Fly   207 TREQSEPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGHDALPAGWEERQDANGRTYYVNHTART 271
            |.:.|..||       :.|..| |.:.|..|          ||:|.|....
Mouse  3597 TSQASVCSS-------QCVSQT-ASDLSVDP----------LPSGLELPVP-------------- 3629

  Fly   272 TQWDRPTVLNSH--SSQSTDDQLASDFQRRFHISVDDTES-------GRSADSISHNSIEDNNNA 327
                 |.:|..|  |||.:.|           ||:..|.|       |...|:....|:.|
Mouse  3630 -----PVLLEPHVVSSQESLD-----------ISLCSTGSLGSLGSLGEPLDNPETASVSD---- 3674

  Fly   328 AGLAYTPKTAATSSAPPNTPT----------------------NNNGILAQIA-------MQYRA 363
            .|..|| .|:..:......|.                      |||.::...:       |:...
Mouse  3675 VGSMYT-VTSLDTQPLATRPIKGFAVVEIRSRAKIEKIRASLFNNNDLIGLSSLDGEDELMEMST 3738

  Fly   364 EEDQDPTVDHTSF-----------------------------VYNSLRHPVAHRQPEISATSLQN 399
            ||....:|.:.|.                             |...:....||.:..:|.|
Mouse  3739 EEILTVSVVNQSLFDTQGSPGLEDYFSDKSIKGEKLVPGAREVLTEIFKSCAHSEQTLSLT---- 3799

  Fly   400 DLRPVREAPGVPDIAIT-NPFTRRAAGNMAGGAGWQQERRRQQMQLHI----QQHQQRQQQQQQN 459
            ..:|:|    |.||.:: .....:..||:                ||:    .:..::..:.|..
Mouse  3800 PAKPIR----VSDIYLSKEQINSQTPGNL----------------LHLFFTNVRPPKKVLEDQLT 3844

  Fly   460 RIL--LDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSD----ISAPSTRRNSEEDNAAVP 518
            :||  ..|...:.:.....:..::||......|....:..|:.    :|:.|....||:.....|
Mouse  3845 QILRKYGVPKPKLDKSKYSKAGKEQHPVKVVSTKRPVTKPPAKDKAVLSSLSRTALSEKKPTVKP 3909

  Fly   519 PM-EQNTGGEEEPLPPRWSMQVAPNGR--------TFFIDHASR--RTTW--------------- 557
            .. |::...|::|.......|..|..:        .|.||.|.:  |:.|
Mouse  3910 KSPEKSKPDEKDPEKSPTKKQEVPEEKYLTLEGFHKFVIDRAKQDIRSVWRAILSCGYDLHFERC 3974

  Fly   558 -----------------------------------------------------IDPRNGRASPMP 569
                                                                 .|||....|.:|
Mouse  3975 ACIDVRHAQKASRKWTLEMDVALVQYINRLCRHLAITPARLHPHEVYLDPADAADPRMACLSNVP 4039

  Fly   570 NQTRR------------VEDDLGPLPEGWEERVH----------TDGRVFYIDHNT--------- 603
            .::.|            :|....||.|..:..::          ..|.:||....|
Mouse  4040 IESLRLRFALLQSLNTTLETFFLPLVELRQTPMYAHSIAALLKEAKGLIFYDTKVTVMNRVLNAT 4104

  Fly   604 --RTTQWEDPRLS-NP-NIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSY 664
              ||.....|.:: :| .|.|..:..|.:     .||....|:..:||:. ::.::..|..:.:|
Mouse  4105 VQRTADHAAPEITLDPLEIVGGEIRASEN-----SYFCQAARQLASVPSS-QLCVKLASGGDPTY 4163

  Fly   665 RIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLF---EYSAMDNYTLQ 726
            ...              :.|.||......|..|.:.:.:.||:.:....|.   ..||::.
Mouse  4164 AFN--------------IRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLLLCPSSAVNK---- 4210

  Fly   727 INNGSGLCNEEHLSY-----FKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDL-KDMESVD 785
             |.|..:.....::|     ..|:|::.|:|:.....|....:..|:|.::.:|:|. :|::..|
Mouse  4211 -NKGKYILTPSPITYGEEQLLHFLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPDQDLQEAD 4274

  Fly   786 TEYYNSLMWIKE----NDPRILELTFCLD--------EDVFGQK------------SQHELKPGG 826
            ...||   ::|:    ||...|| ..|.:        |...|.|            .:.||...|
Mouse  4275 ILTYN---YVKKFESINDESELE-ALCAEIASQHLATESPEGPKPCCRFTYLTMTGEEVELCSRG 4335

  Fly   827 ANIDVTNENKDEYIKLVIEWRF-VARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNI 890
            .:|.|..||||.|...:...|. ..:..|.:::...|.||||||.|:......|:||..||:..|
Mouse  4336 RHIPVAWENKDIYAAAIRSLRLRELQNMECVTAVRAGLGSIIPLQLLTTLSPLEMELRTCGLPYI 4400

  Fly   891 DVKDWRENTLY-----KGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYG 950
            :::..:.:|:|     :.|.|     |:.||.|:..|:.|...:.::|.....|:|   |.....
Mouse  4401 NLEFLKAHTMYQVGLMETDQH-----IELFWGALEMFTQEELCKFIKFACNQERIP---FTCPCK 4457

  Fly   951 SNGPQMFTIEKW-----------GTPNN-FPRAHTCFNRLDLPPYEGYLQLKDKLIKAI 997
            ..||....:..:           |.|:: :.|..||...:.||.|.....:.:||..||
Mouse  4458 DGGPDTAHVPPYPMKIAPPDGTAGPPDSRYIRVETCMFMIKLPQYSSLETMLEKLRCAI 4516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	26/134 (19%)
		WW	248..277	CDD:278809	4/28 (14%)
		WW	531..560	CDD:278809	8/106 (8%)
		WW	581..613	CDD:197736	10/52 (19%)
		HECTc	650..1003	CDD:238033	91/399 (23%)
		HECTc	674..1003	CDD:214523	89/375 (24%)
Hectd4	XP_006530414.1	CCDC154	149..>233	CDD:373856
		SPRY_HECT_like	2507..2662	CDD:293970
		HECTc	4127..4520	CDD:391658	97/427 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910