DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and HERC4

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_011537894.1	Gene:	HERC4 / 26091	HGNCID:	24521	Length:	1081	Species:	Homo sapiens

Alignment Length:	356	Identity:	108/356 - (30%)
Similarity:	181/356 - (50%)	Gaps:	18/356 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   654 IRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYS 718
            :||.:|:.|:..::......| .|..|.|.|.||..:|.||:.:|:|.|:.:|:.:|.||:|.|.
Human   737 VRRENIVGDAMEVLRKTKNID-YKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYY 800

  Fly   719 AMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMES 783
            . |:..:..::.:    .|....|..||.|.|:|:|:..::|..|....||.:|:|...|.|::.
Human   801 E-DSRLIWFSDKT----FEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKE 860

  Fly   784 VDTEYYNSLMWIKENDPRILELTFCLDEDV----FGQKSQHELKPGGANIDVTNENKDEYIKLVI 844
            :..:...|:..:.:.....:|.||||:..:    ||.....||...||:..|..:|:.|::...:
Human   861 LMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYV 925

  Fly   845 EWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNH 909
            ::.|...|.....:|..||..:....::.:|..:||:.::.|..|.|.|:..:||.|||:|...|
Human   926 DYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEH 990

  Fly   910 IIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNF-PRAHT 973
            ..|:.||........|.:.:.|.|:||:.|:|:.|.|.|       ...|:..|....: |.:||
Human   991 PTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL-------KLVIQSTGGGEEYLPVSHT 1048

  Fly   974 CFNRLDLPPYEGYLQLKDKLIKAIEGSQGFA 1004
            |||.||||.|.....|:.|||:||:.::||:
Human  1049 CFNLLDLPKYTEKETLRSKLIQAIDHNEGFS 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736
		HECTc	650..1003	CDD:238033	106/353 (30%)
		HECTc	674..1003	CDD:214523	102/333 (31%)
HERC4	XP_011537894.1	RCC1	2..368	CDD:332518
HERC4	XP_011537894.1	HECTc	733..1079	CDD:238033	107/354 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810