DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and MAGI3

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_001136254.1	Gene:	MAGI3 / 260425	HGNCID:	29647	Length:	1481	Species:	Homo sapiens

Alignment Length:	781	Identity:	150/781 - (19%)
Similarity:	242/781 - (30%)	Gaps:	326/781 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   454 QQQQQNRILLDVDHRQQEPQHRGQRHQQQHR-----PSNEDTDHTDSHNPSDISAPSTRRNSEED 513
            |....:::|.|.:...:..:.|.....:..|     |..|:.:..::.|.|. :|.:..|:||..
Human   201 QPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEEEDEDKEAINGSG-NAENRERHSESS 264

  Fly   514 N--AAVPPMEQNTGGEE-----------EPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRA 565
            :  ..||...|.....:           ||||..|.|.....|..:||||.::.|||:|||..:.
Human   265 DWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKK 329

  Fly   566 SPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDP--------RLSNPNIAGQA 622
            :..|..   .||  |.||.|||:........:|:||..:.||:|:|        :|....| |.:
Human   330 AKAPED---CED--GELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQVEI-GSS 388

  Fly   623 VP------YSRDYKQ-KYEYFKSHIRKPT----------NVPNKFEIRIRRTSILED-------- 662
            .|      ::||..| |....::.::|.|          :.|::|   ::..::|:|
Human   389 KPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEF---LQVKNVLKDGPAAQDGK 450

  Fly   663 ----------SYRIISSVTKTD------LLKTKLWVEF--------------------------- 684
                      :...:...|..|      |:....:|..
Human   451 IAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVIN 515

  Fly   685 -----EGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGL-----CNEEHL 739
                 :|||             .::.:.|.|...:.|.:....:||   .|.||     .:|:.:
Human   516 GQSLTKGET-------------CMNPQDFKPGAMVLEQNGKSGHTL---TGDGLNGPSDASEQRV 564

  Fly   740 SY-----------------------FKFIGRIAGMAVYHGKLLDAFF---------IRPFYKMML 772
            |.                       |.......|..|  ..:||:.:         |:..|...:
Human   565 SMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKV--KMILDSQWCQGLQKGDIIKEIYHQNV 627

  Fly   773 Q------------------------------KPIDLKDMESVDTEYYNSLMWIKENDPRILELTF 807
            |                              .|.....|::...|...||..|.|..|:.:....
Human   628 QNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPP 692

  Fly   808 CL----------DEDVFGQKSQHELKPGGA-NIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLD 861
            .:          .|.....|:.:|.||... ::||.                   :::|.|.|
Human   693 SIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVF-------------------LRKQESGF-- 736

  Fly   862 GF--------------GSIIPLNL------IKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYH 906
            ||              |:||||..      ::..||     ||| |..|.|         ||..|
Human   737 GFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADE-----LMC-IDGIPV---------KGKSH 786

  Fly   907 MNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGF-------KELYGSNGPQMFTIEKW-G 963
                                 .::|..:|..:|   ||.       |..||...|:..:.:.: .
Human   787 ---------------------KQVLDLMTTAAR---NGHVLLTVRRKIFYGEKQPEDDSSQAFIS 827

  Fly   964 TPNNFPRAHTCFNRLDLP-------PYEGYLQLKD----------------------KLIKAIEG 999
            |.|..||    .||.::|       ||:..||.|:                      |:.:.|||
Human   828 TQNGSPR----LNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEG 888

  Fly  1000 S 1000
            |
Human   889 S 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	12/28 (43%)
		WW	581..613	CDD:197736	12/39 (31%)
		HECTc	650..1003	CDD:238033	90/542 (17%)
		HECTc	674..1003	CDD:214523	86/500 (17%)
MAGI3	NP_001136254.1	Interaction with ADRB1 and TGFA. /evidence=ECO:0000250	18..106
		PDZ_signaling	24..101	CDD:238492
		NK	123..>197	CDD:327404
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..273		15/72 (21%)
		WW	294..326	CDD:197736	15/31 (48%)
		WW	342..372	CDD:238122	11/29 (38%)
		Interaction with PTEN. /evidence=ECO:0000269\|PubMed:10748157	410..492		10/84 (12%)
		PDZ	413..493	CDD:214570	10/82 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..570		7/30 (23%)
		PDZ	575..656	CDD:214570	8/82 (10%)
		Interaction with ADGRB1. /evidence=ECO:0000269\|PubMed:10748157	726..808		28/141 (20%)
		PDZ_signaling	726..807	CDD:238492	28/140 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..843		7/25 (28%)
		PDZ_signaling	849..935	CDD:238492	10/41 (24%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000269\|PubMed:10748157, ECO:0000269\|PubMed:16904289	851..938		8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..976
		PDZ_signaling	1022..1100	CDD:238492
		Red1	<1132..1461	CDD:311769
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1170..1481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810