DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nedd4 and Nedd4

DIOPT Version :9

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:XP_017450968.1 Gene:Nedd4 / 25489 RGDID:3157 Length:1223 Species:Rattus norvegicus


Alignment Length:1045 Identity:446/1045 - (42%)
Similarity:552/1045 - (52%) Gaps:263/1045 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 AAAALP-VPSSSSSV-AGGDVPRPPPRRRAASVAGQQQTRQEFGNGYTPRRSLAAVNDS---GDS 69
            |:..|| .|.:.|.| ..|::.||..:|.....|.|:..  ..|..|.....|:::..|   |..
  Rat   395 ASPCLPTTPDTDSHVNIRGELERPNSQRSRGRAALQRSV--SLGGTYPNVSCLSSLKHSCSKGGP 457

  Fly    70 CHLRIVVLTGQSLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTKKKTLNPTWNEEFIFRVKP 134
            ..|.|...:|                        .|..:||.            |.|    |...
  Rat   458 SQLLIKFASG------------------------NDGKVDSF------------WRE----RDLT 482

  Fly   135 SEHKLVFQVFDENRLTRDDFLGMVELTLVNLPTEQEGRTIGEQSYT-----LRPRRSVGAKSRIK 194
            :|...|       |.|||||||.|::.|..||||....   |:.||     |.||   ..|||:|
  Rat   483 NELSGV-------RKTRDDFLGQVDVPLYPLPTENPRM---ERPYTFKDFVLHPR---SHKSRVK 534

  Fly   195 GTLRIYHAFIRETREQSEPSSGNSDGEWEHVEATNAG---------ETSAQ--PHPFPTGGHDAL 248
            |.||:...::        |.:|:.|...:..|....|         .|..|  |.|.|      |
  Rat   535 GYLRLKMTYL--------PKNGSDDENADQAEELEPGWVVLDQPDAATHLQHPPEPSP------L 585

  Fly   249 PAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSA 313
            |.|||||||..||||||||.:|||||.||         |.:|.|..|            |:|   
  Rat   586 PPGWEERQDVLGRTYYVNHESRTTQWKRP---------SPEDDLTDD------------ENG--- 626

  Fly   314 DSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVY 378
                     |....|..|:|.:                   .||:      ||.|          
  Rat   627 ---------DIQLQAQRAFTTR-------------------RQIS------EDVD---------- 647

  Fly   379 NSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQ 443
                .|..|..||                                        .|          
  Rat   648 ----GPDNHESPE----------------------------------------NW---------- 658

  Fly   444 LHIQQHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQ--------QHRPSNE-DTDHTDSHNPS 499
                                ::....:...:.||..|.        |.|.:.| ||..|...||:
  Rat   659 --------------------EIVREDENTMYSGQAVQSPPSGHPDVQVRLAEELDTRLTMYGNPA 703

  Fly   500 DISAPSTRRNSE-----------EDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASR 553
             .|.|.|..|..           |:...:|.:...:.|    |||.|..:....||::::||.|:
  Rat   704 -TSQPVTSSNHSSRGGSSQTCIFEEQPTLPVLLPTSSG----LPPGWEEKQDDRGRSYYVDHNSK 763

  Fly   554 RTTWI------DPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPR 612
            .|||.      |||:...:.:..:|....:||||||.|||||.|||||||:|:||.:.|||||||
  Rat   764 TTTWSKPTMQDDPRSKIPAHLRGKTPVDSNDLGPLPPGWEERTHTDGRVFFINHNIKKTQWEDPR 828

  Fly   613 LSNPNIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLK 677
            :.|..|.|.|||||||||:|||:|:..::|.|::|||||:::||.:|||||||.|..|.:.|.||
  Rat   829 MQNVAITGPAVPYSRDYKRKYEFFRRKLKKQTDIPNKFEMKLRRANILEDSYRRIMGVKRADFLK 893

  Fly   678 TKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYF 742
            .:||:||:||.||||||:|||||:|:||||||||||||||||.||||||||..||||||:|||||
  Rat   894 ARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF 958

  Fly   743 KFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRILELTF 807
            |||||:||||||||||||.|||||||||||||.|.|.||||||:|||:||.||.||||..|:|.|
  Rat   959 KFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEYYSSLRWILENDPTELDLRF 1023

  Fly   808 CLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLI 872
            .:||::|||..|||||.||:.:.|||:||.|||.|||:||||.|:::||::|.:||..:||.:||
  Rat  1024 IIDEELFGQTHQHELKTGGSEVVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLI 1088

  Fly   873 KIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGT 937
            |||||:||||||||:.::||.||||:|.||..|.:||.:|.|||:|||...:|.|.|||||||||
  Rat  1089 KIFDENELELLMCGLGDVDVNDWREHTKYKNGYSLNHQVIHWFWKAVLMMDSEKRIRLLQFVTGT 1153

  Fly   938 SRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQG 1002
            ||||||||.|||||||||.||:|:||||:..||||||||||||||||.:.:|.|||..|||.:||
  Rat  1154 SRVPMNGFAELYGSNGPQSFTVEQWGTPDKLPRAHTCFNRLDLPPYESFDELWDKLQMAIENTQG 1218

  Fly  1003 FAGVD 1007
            |.|||
  Rat  1219 FDGVD 1223

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 38/137 (28%)
WW 248..277 CDD:278809 22/28 (79%)
WW 531..560 CDD:278809 12/34 (35%)
WW 581..613 CDD:197736 24/31 (77%)
HECTc 650..1003 CDD:238033 249/352 (71%)
HECTc 674..1003 CDD:214523 236/328 (72%)
Nedd4XP_017450968.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 463 1.000 Domainoid score I454
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 866 1.000 Inparanoid score I397
OMA 1 1.010 - - QHG49869
OrthoDB 1 1.010 - - D142537at33208
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 1 1.000 - - otm45750
orthoMCL 1 0.900 - - OOG6_100256
Panther 1 1.100 - - LDO PTHR11254
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1682
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.980

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