DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and ptr1

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_594902.1	Gene:	ptr1 / 2542537	PomBaseID:	SPAC19D5.04	Length:	3227	Species:	Schizosaccharomyces pombe

Alignment Length:	402	Identity:	177/402 - (44%)
Similarity:	250/402 - (62%)	Gaps:	27/402 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   613 LSNPNIAGQAVPYSRDYKQKYEYFKSHIRK--------PTNVPNKFEIRIRRTSILEDSYRIISS 669
            :.||.:.        :::.|..||...:.:        |.|      |.:||..:..||||.:..
pombe  2839 VKNPKVL--------EFENKRNYFNRQLHEEAAKEQYPPLN------ITVRRDHVFLDSYRALHF 2889

  Fly   670 VTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLC 734
            ....::..:||.:.|..|.|:|.||:.|||..:|:::||||.|.||.....|..|...|..|.:
pombe  2890 KDADEVKFSKLNIHFRDEEGVDAGGVTREWLQVLARQMFNPDYALFLPVTGDATTFHPNRDSSV- 2953

  Fly   735 NEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEND 799
            |.:|||:|||.|||.|.|:|.|:|||..|.|..||.||.:.:.:||:||:|.:||.||:|:..||
pombe  2954 NPDHLSFFKFTGRIIGKALYDGRLLDCHFSRAVYKHMLHRSVSVKDIESLDPDYYKSLVWMLNND 3018

  Fly   800 -PRILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGF 863
             ..|:...|.:::||||:|:..:|.|.|.||.||..||..|:..:::::....||:|:.|.||||
pombe  3019 ITDIITEEFAVEKDVFGEKTVVDLIPNGRNIPVTELNKQNYVNRMVDYKLRESVKDQLKSLLDGF 3083

  Fly   864 GSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRS 928
            ..|||.:||:||:|.|||||:.|:..||:.||:.||.|.| |:::...:|||||||.||..|.|:
pombe  3084 SDIIPSHLIQIFNEQELELLISGLPEIDIDDWKNNTEYHG-YNVSSPQVQWFWRAVRSFDEEERA 3147

  Fly   929 RLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEK-WGTPNNFPRAHTCFNRLDLPPYEGYLQLKDK 992
            :||||.||||:||:||||||.|.:|.|.|.|.| :|:.|..|::|||||:||||.|:.|.||:..
pombe  3148 KLLQFATGTSKVPLNGFKELEGMSGFQRFNIHKSYGSLNRLPQSHTCFNQLDLPEYDTYEQLRSM 3212

  Fly   993 LIKAI-EGSQGF 1003
            |:.|| |||:||
pombe  3213 LLTAINEGSEGF 3224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736	177/402 (44%)
		HECTc	650..1003	CDD:238033	168/355 (47%)
		HECTc	674..1003	CDD:214523	161/331 (49%)
ptr1	NP_594902.1	DUF908	96..367	CDD:283630
		DUF913	436..735	CDD:283642
		HARE-HTH	<1930..2018	CDD:294801
		DUF4414	2267..2347	CDD:291075
		HUL4	2314..3227	CDD:227354	177/402 (44%)
		HECTc	2870..3225	CDD:238033	171/363 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810