Protein Alignment Nedd4 and Plekha5

DIOPT Version :9

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: NP_647556.1
• Gene: Plekha5 / 246237
• RGDID: 621175
• Length: 1281
• Species: Rattus norvegicus
• Alignment Length: 608
• Identity: 122/608 - (20%)
• Similarity: 213/608 - (35%)
• Gaps: 191/608 - (31%)

  Fly   531 LPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGR 595
            ||..|:..:...||.|||:..::.|||:.|..|.|  :....||...|   ||.||||....:|.
  Rat    13 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEA--VVTGHRRQSTD---LPTGWEEAYTFEGA 72

  Fly   596 VFYIDHNTRTTQWEDPRLSNPN------IAGQAVPYSRDYKQKYEYFKSHIRKPT--NVPNKFEI 652
            .:||:||.|....:.|....|:      :.......:...::|.|...|.|.:.:  |:.:.:.:
  Rat    73 RYYINHNERKVTCKHPVTGQPSQDNCIFVVNDQTVATMTSEEKKERPISMINEASNYNMASDYTV 137

  Fly   653 R----IRRTSILEDSYRIISSVTKTDLLK--------TKLWVEFEGETGLDYGGLAREWFYLLSK 705
            .    :.|||  ..|.::.:...:::.:|        .:.|:..:..||:..  ..:.||.|...
  Rat   138 HPMSPVGRTS--RASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKL--WKKRWFVLSDL 198

  Fly   706 EMFNPYY------GLFEYSAMDNYTLQINNGSGLCNEEHLS-YFKFIGRIAGMAVYH-----GK- 757
            .:|  ||      |:.....:.::.:.:     |..|:|:: .:.|......|..|:     ||
  Rat   199 CLF--YYRDEKEEGILGSILLPSFQIAM-----LTAEDHINRKYAFKAAHPNMRTYYFCTDTGKE 256

  Fly   758 -------LLDAFFIR--PFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRILELTFCLDEDV 813
                   :|||..::  |..::.....:|....||..|:..|::     .:.|:|
  Rat   257 MELWMKAMLDAALVQTEPVKRITFNFRVDKITTESASTKETNNI-----PNHRVL---------- 306

  Fly   814 FGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFG-SIIPLNLIKIF-- 875
                    ::|     :|.|..|::.|..:.|.|  |...|:.....||.. .:..:|.:|:.
  Rat   307 --------IRP-----EVQNNQKNKEISKIEEKR--ALEAERYGFQKDGQDRPLTKINSVKLNSL 356

  Fly   876 -DEHELELLMCGIQNIDVKDWRENTL-----------YKGDYHMN------------------HI 910
             .|:| ....|..|||..:....|..           .:|..|.|                  ..
  Rat   357 PSEYE-SGPACPPQNIHYRPINVNNSDSKAVNVSLADVRGGSHPNTGPLATEADRVIQRTNSMQQ 420

  Fly   911 IIQWFW-----------RAVLSFS---NEMRSRLLQFVTGTSRVPMNGFKEL------------- 948
            :.||..           |.|:|:.   ..|.|...|.:   :|.| .|::.|
  Rat   421 LEQWIKVQKGRGLEEEPRGVISYQTLPRNMPSHRAQIL---ARYP-EGYRTLPRNSKTRPESICS 481

  Fly   949 -----YGSNGP------------QMFTIEKW------GTPNNFPRAHTCFNRLDLPPYEGYLQLK 990
                 :...||            .|:.:.:|      ...:..|| |:|   |..|...|  ::.
  Rat   482 VTPSGHEKTGPGAEEKRRSMRDDTMWQLYEWQQRQFYHKQSTLPR-HSC---LSSPKAMG--KVS 540

  Fly   991 DKLIKAIEGS---------QGFA 1004
            |:.:.:|..|         |||:
  Rat   541 DQTMHSIPTSPSHVPAAAYQGFS 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	11/28 (39%)
		WW	581..613	CDD:197736	13/31 (42%)
		HECTc	650..1003	CDD:238033	84/478 (18%)
		HECTc	674..1003	CDD:214523	80/450 (18%)
Plekha5	NP_647556.1	WW	13..42	CDD:278809	11/28 (39%)
		WW	59..88	CDD:278809	12/28 (43%)
		PH_PEPP1_2_3	165..268	CDD:270068	20/111 (18%)
		PH	171..267	CDD:278594	19/104 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900